Antibiotics: Dosage, Indications and Tissue Penetration

Antibiotics: Dosage, Indications and Tissue Penetration

Indication and Dosage

Beta-Lactams and Beta-Lactam Plus Beta Lactamase Inhibitors

Amoxicillin

Ampicillin 

Ampicillin Sulbactam

Amoxicillin Clavulanic Acid

Cefpodoxime

Cefixime

Cefuroxime

Ceftriaxone

Quinolones

Ciprofloxacin

Norfloxacin

Levofloxacin

Moxifloxacin

Gemifloxacin

Macrolides

Erythromycin

Azithromycin

Clarithromycin

Tissue Penetration

Cephalosporins

Cepodoxime

The Tissue Penetration of Cefpodoxime was approximately 2-fold higher than that of cefixime (tissue AUC 15.4 mg.h/L for cefpodoxime vs. 7.3 mg.h/L for cefixime)

Cefixime

Cefuroxime

Penicillin

Piperacillin

Amoxicillin

Quinolones

Gemifloxacin

Macrolides

Clarithromycin