CLAZE Gel (Arginine HCl 20% + Lactic acid 20% + Kojic acid 5% + Arbutin 2% + Citric acid 2%)

Table of Content

Chemical peeling is the most popular cosmetic procedure, used since time immemorial.  In this procedure, a chemical agent is applied to the skin to cause controlled destruction of the skin layers, followed by tissue remodelling. Chemical peels are a powerful tool to treat various skin diseases and aesthetic disorders.

Based upon how deeply a peel penetrates the skin, peels are classified as follows: superficial (epidermis), medium (up to the papillary dermis), and deep peels (mid-reticular dermis). The peel depth is influenced by factors such as the type of chemical used, peel concentration, mode of application, skin type and condition or the time allowed for the peel to be in contact with the skin.

CLAZE Gel contains arginine, lactic acid, kojic acid, arbutin and citric acid. It is available in a bottle of 60 ml.

Composition

Arginine HCl 20%, Lactic acid 20%, Dimethylaminoethanol 8%, Kojic acid 5%, Arbutin 2%, Citric acid 2%, Aloevera barbadensis 1%, Allantoin 0.5%, Aqua 25.6%, Urea 5%, Ethoxydiglycol 10%, Xanthan gum 0.8%, Disodium EDTA 0.1 %

Pharmacology

Arginine (pKa-2.17, 9.04) provides careful exfoliation of the stratum corneum. It is an amino acid with a large molecular size, leading to a slower skin penetration and has a milder action. It rejuvenates and moisturizes the skin.1

Lactic acid (pKa-3.86) is an AHA that aids in skin renewal and moisturization.2

Dimethylaminoethanol has been reported to increase skin firmness with possible improvement in the underlying facial muscle tone.3

Kojic acid is a naturally occurring fungal product that inhibits the production of  the enzyme, tyrosinase. 4

Arbutin inhibits the production of free tyrosinase.4

Citric acid (pKa-3.15, 4.77, 6.40) is a powerful skin brightener5; it reduces the activity of the enzyme, tyrosinase. 6

Aloe barbadensis (Aloevera) has moisturizing, wound healing and anti-inflammatory properties.7

Allantoin acts as an anti-irritant.8

Indications

  • Facial rejuvenation
  • Periorbital hyperpigmentation
  • Lip lightening

Directions for Use

  • Clean and remove the makeup with degreasing lotion.
  • Protect the areas around the eyes, mouth and nose using petroleum jelly.
  • Using a cotton bud/gauze/brush, apply the peel quickly (approx. 20–30 seconds) to the affected area/face.
  • Treat areas in the following order: forehead, right cheek, nose, left cheek and chin.9
  • Apply feathering strokes at the edges to blend with the surrounding skin and prevent demarcation lines.9
  • Remove the peel with water after 5–10 minutes.
  • Apply a broad-spectrum sunscreen.

Caution

  • A transient stinging sensation and slight flushing of the skin are normal; remove the peel immediately with plenty of water, if hotspots or erythema appears. To avoid contact with eyes, nostrils and mouth, elevate head up to 45°. If contact occurs, rinse with water.9 Never leave the room before completing the procedure
  • Patch testing may be advised for patients with a history of allergy or skin sensitivity.
  • Chemical peeling with CLAZE Gel is contraindicated in patients with active viral, bacterial, fungal infections, unrealistic patient expectations, on photosensitizing drugs or patients who have undergone resurfacing procedures or any cutaneous surgeries (in the area to be treated) in the last 6-12 months. 9

Presentation

60 ml Gel

References

  1. Available at: http://cosmetology-info.com/1/Arginine-peel/. Last accessed on: 24-11-15
  2. Step by Step: Chemical Peels. JP Medical Ltd; 2014. 147-148 p
  3. Am J Clin Dermatol. 2005;6(1):39-47
  4. Skin Therapy Lett. 2004 Jun-Jul;9(6):1-3
  5. Milady’s Aesthetician Series: Treating Diverse Pigmentation. Cengage Learning; 2012. 192 p
  6. J Cutan Aesthet Surg. 2013 Jan; 6(1):4-11.
  7. Indian J Dermatol. 2008; 53(4): 163–166
  8. Procedures in Cosmetic Dermatology Series: Chemical Peels. Elsevier Health Sciences; 2010. 10 p
  9. Indian J Dermatol Venereol Leprol. 2008 Jan 1; 74(7): S5-11.