Viral Infection And Allergy Status Impact Severity Of Asthma Symptoms In Children With Asthma Exacerbations

Ann Allergy Asthma Immunol.

Detection of respiratory viruses is frequent in uncontrolled asthmatics. Uncontrolled subjects with viruses have more acute symptoms during exacerbations, especially in those with allergy. Periostin was highest in subjects with the most acute symptoms, regardless of control status. Taken together, these data imply synergy between viral infection and allergy in subjects with uncontrolled asthma when considering acute asthma symptoms and nasal inflammation during an exacerbation of asthma.