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    15 Feb, 2019
    A new retrospective study confirmed the efficacy and safety of new generation super-mini percutaneous nephrolithotomy (New-SMP) in the treatment of ≥20 mm renal stone. Researchers enrolled patients with >20 mm renal stone undergoing New-SMP procedures between 1st April, 2016 to 1st July, 2018 in this recent study. Patients with ipsilateral DJ stent and/or nephrostomy tube preoperatively,... Read more
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    15 Feb, 2019
    A recent study based on real-world data revealed that the impact of intensification of diabetes treatment (addition of third or fourth drug) primarily depends on the pre-intensification glycosylated hemoglobin (HbA1C) values of the diabetes patient. Diabetes patients who had a higher baseline HbA1C value (>8%) achieved a more effective glycemic control.  Researchers concluded that most... Read more
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    15 Feb, 2019
    The efficacy and safety of once-daily or twice-daily nasal spray with a fixed-dose combination of the antihistamine olopatadine hydrochloride and the corticosteroid mometasone furoate intended for the treatment of seasonal allergic rhinitis (SAR) was evaluated in a ragweed pollen environmental exposure chamber. The results confirmed that twice-daily and once-daily olopatadine/mometasone nasal... Read more
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    15 Feb, 2019
    Long term prophylaxis with entecavir (ETV) and other nucleos(t)ide analogs (NUCs) was effective and safe for preventing recurrence of hepatitis B virus (HBV) infection in patients after liver transplantation (LTx), reported the researchers of a new study. Both the regimens led to a good graft function. Although few patients became hepatitis-B surface antigen (HBsAg) positive, they transformed... Read more
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    15 Feb, 2019
    Assessment of patients’ diabetes self-care related knowledge has a crucial role in developing appropriate diabetes education programs, claimed a recent study. This study conducted in Jordan revealed that while diabetes patients had good amount of knowledge on meal-planning, monitoring glucose levels, foot care, medications and diabetes-associated complication, their knowledge on the role of... Read more
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    15 Feb, 2019
    Inguinal hernias are a common problem and account for 75% of abdominal wall hernias. Recently a meta-analysis of a randomized controlled trial (RCTs) and observation studies compared the outcomes of open darn repair with open mesh repair in patients undergoing inguinal hernia repair. The study showed that the outcomes with open darn repair were comparable with open mesh repair for inguinal... Read more
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    15 Feb, 2019
    Individuals suffering with influenza-like illness (ILI), are burdened with a 40% increased risk of ischemic stroke, irrespective of their gender, race, or geographical setting, hinted a latest study1. In fact, the risk of stroke was particularly high within the first 30 days following the ILI. Yet another recent study demonstrated that ILI also increased the risk of non-traumatic cervical artery... Read more
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    15 Feb, 2019
    There is growing evidence on tenofovir disoproxil fumarate (TDF)-associated nephrotoxicity, however, its use in the management of HIV-1 infection is on the rise especially in resource-limited settings.  Recently a retrospective study evaluated the impact of long-term TDF exposure on renal function in a cohort of HIV-1-infected Nigerians. The study showed that long-term exposure to TDF-based... Read more
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    13 Feb, 2019
    The gut microbiome-brain communication has mostly been explored in animal models. However, the human research has been lagging behind. The study of microbial neuroactive potential is limited due to lack of dedicated reference databases and tools. A large fecal microbiome population study established a significant co-variation between gut microbiota composition and mental health affecting the... Read more
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    13 Feb, 2019
    An umbilical hernia is a midline abdominal wall defect from 3 cm above to 3 cm below the umbilicus. Symptomatic or clinically apparent umbilical hernias are repaired surgically by suture repair or use of mesh. However, the optimal methodology of surgical treatment in adults with this condition remains controversial. A recent meta-analysis of randomized controlled trials (RCTs) that compared the... Read more
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    13 Feb, 2019
    Omadacycline is an aminomethylcycline antibiotic that can be administered once daily either orally or intravenously. It is active against pathogens that commonly cause such infections, including antibiotic-resistant strains. A recent double-blind randomized controlled trial compared safety and efficacy of omadacycline with linezolid for treatment of acute bacterial skin and skin-structure... Read more
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    13 Feb, 2019
    Atopy, rather than asthma or rhinitis, plays a critical role in determining increased levels of total nitric oxide products (NOx) in exhaled breath condensate (EBC), concluded a nested cross-sectional study. The prior use of inhaled corticosteroids (ICS) should also be considered as this factor masks the association between NOx and sensitization in older subjects. EBC could be a potential non-... Read more
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    13 Feb, 2019
    A recent meta-analysis confirmed that dipeptidyl peptidase-4 inhibitors (DPP-4i) had a better safety profile in terms of lesser adverse events, cardiovascular events, hypoglycemia and severe hypoglycemic events as compared to sulfonylureas. Furthermore, the benefits of DPP-4i in terms of safety profile were enhanced when combined with metformin. Since DPP-4i and sulfonylureas have similar... Read more
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    12 Feb, 2019
    A substantial number of patients with mild traumatic brain injury (mTBI) may develop posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) within 3 to 6 months, reaffirmed determined a recent study.  Lower education, having African-American origin (race/ethnicity), previous history of mental illness, and certain causes of injury were the factors responsible for increased... Read more
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    12 Feb, 2019
    Novel Tretinoin 0.05% lotion formulation was developed using novel polymerized emulsion technology to provide an alternative option to treat acne patients who may be sensitive to the irritant effects of other tretinoin formulations.  A recent post-hoc analysis of two multicenter, randomized, double-blind, vehicle-controlled Phase 3 studies determined the safety and efficacy of this... Read more