• 0
    18 Jun, 2019
    A recent meta-analysis showed that the overall survival (OS) and recurrence-free survival (RFS) outcomes with partial nephrectomy (PN) for 4 cm to 7 cm renal cell carcinoma (RCC) were comparable to radical nephrectomy (RN). Additionally, PN was associated with better renal function preservation as compared to RN. Nevertheless, cancer special survival (CSS) outcome was better with RN. The... Read more
  • 0
    18 Jun, 2019
    Prenatal paternal tobacco smoke (PTS) was associated with epigenetic modifications in certain genes, such as LMO2 and IL-10, and an increased risk of asthma in the offspring, concluded a new study in Taiwan. PTS exposure increased the CG methylation levels of the genes in a dose-dependent manner. Highest risk of asthma correlated to higher CG methylation levels of LMO2_E148,... Read more
  • 0
    17 Jun, 2019
    JUST-ACT study is a recent phase 3, multicenter, randomised, double-blind, parallel- group, placebo-controlled study.  The aim was to demonstrate the non-inferiority of tocilizumab (TCZ) monotherapy compared with TCZ+ methotrexate (MTX) in MTX-inadequate responders with active rheumatoid arthritis (RA). The results showed an initial efficacy of TCZ when added to background MTX in patients... Read more
  • 0
    17 Jun, 2019
    Whole-pelvic irradiation (WPRT) in addition to dose-escalated prostate bed irradiation (PBRT) was associated with longer biochemical progression-free survival (bPFS) compared to PBRT in patients with locally advanced prostate carcinoma who underwent dose-escalated radiotherapy. This benefit was observed only in patients with increasing prostate specific antigen (PSA) values and not in patients... Read more
  • 0
    17 Jun, 2019
    Perioperative topical antibiotics that reduce the load of organisms in the surgical field can effectively minimize the risk of post-operative bacterial endophthalmitis. A recent study demonstrated that moxifloxacin 0.5% ophthalmic solution penetrated the anterior chamber to a greater extent than gatifloxacin 0.5%. Moxifloxacin is thus a better choice for prophylaxis before intraocular surgeries,... Read more
  • 0
    14 Jun, 2019
    Obesity-associated type 2 diabetes mellitus (T2DM) has been effectively treated with bariatric surgery such as laparoscopic sleeve gastrectomy with high reported rates of postoperative resolution of T2DM. A recent retrospective study evaluated the effects of laparoscopic sleeve gastrectomy on glucose tolerance in Japanese obese patients with T2DM, and factors that influence diabetes remission... Read more
  • 0
    14 Jun, 2019
    Schizophrenia, a neurodevelopmental disorder, is associated with cognitive impairment that may become evident during childhood. A recent study identified specific social and family factors that influenced cognition in schizophrenia patients. Schizophrenia patients predisposed to cognitive decline faced lack of parental involvement and family breakdown and hardship along with lower... Read more
  • 0
    14 Jun, 2019
    A recent study that compared the prognosis of patients with pediatric-onset MS (POMS) and adult-onset MS (AOMS), revealed that both patient subgroups followed a distinctive clinical course. Although the POMS cases had a slower disability progression than the AOMS cases, they reached disability milestones at a significantly younger age. POMS patients with primary progressive disease, active early... Read more
  • 0
    14 Jun, 2019
    The surgery for periprosthetic femoral fracture (PFF) with revision of the femoral component can be very demanding technically. It is associated with a high rate of complications and reoperations. Direct anterior approach (DAA) has become the standard surgical approach for primary THA and the number of revisions done through this interval is increasing. Therefore, can DAA interval be expanded to... Read more
  • 0
    14 Jun, 2019
    Tenofovir alafenamide (TAF)-containing regimens have demonstrated high efficacy and favorable changes in renal biomarkers compared to a variety of unboosted and ritonavir (RTV)- or cobicistat (COBI)-boosted tenofovir disoproxil fumarate (TDF) containing regimens. However, the comparative incidence of clinically significant renal events is unknown. A recent large integrated analysis of people... Read more
  • 0
    14 Jun, 2019
    Narrowband ultraviolet B (nbUVB) phototherapy is the preferred psoriasis treatment. However, very few studies have measured the impact of nbUVB phototherapy on patient-reported measures of health-related quality of life (HRQoL) in psoriasis patients. A recent randomized placebo-controlled study evaluated the impact of both adalimumab and phototherapy compared to each other and... Read more
  • 0
    14 Jun, 2019
    Superficial dermatophytosis commonly called tinea infection includes superficial fungal infection of the skin, hair, and nail. Trichophyton rubrum has been attributed to be the most common causative dermatophyte in India. A recent study assessed the quality of life (QoL) of Indian patients suffering from superficial dermatophytosis. The results of this cross-sectional observational study showed... Read more
  • 0
    14 Jun, 2019
    Beta (β)-blockers may reduce the risk of death in patients with chronic heart failure (CHF) and atrial fibrillation (AF), stated a recent meta-analysis. A significant decrease in all-cause mortality in this subgroup of patients treated with β blockers was evident only in observational studies but not in the randomized controlled trials (RCTs). Beta-blockers did not cut down the rate of... Read more
  • 0
    13 Jun, 2019
    This was the first ever study that assessed the relationship between daily allergy symptoms and ragweed pollen concentration in European children. The lag effects on symptoms and pollen thresholds resulting in the occurrence of symptoms were evaluated. This study highlighted how different symptoms responded to the varying ragweed pollen concentrations over different time periods. The symptoms... Read more
  • 0
    13 Jun, 2019
    Vildagliptin is widely used for the treatment of type-2 diabetes mellitus () but specific requirements on cardiovascular (CV) safety assessment, issued by the US FDA has been a major concern. A recent study providing real-world data has revealed that vildagliptin did not increase the risk of CV death, nonfatal myocardial infarction (MI), nonfatal stroke, and hospitalization for heart failure... Read more