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    14 Feb, 2020
    A recent study suggested that increasing exposure to oral antibiotics in early postnatal life does not reduce lung function in children with a family history of allergic diseases. Unwarranted use of antibiotics should be minimized in children, but concerns regarding long-term lung health should not be the reason behind this rationalization of use, summed up the researchers. Along with the... Read more
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    14 Feb, 2020
    Researchers have recently devised a new method for short-term intensive insulin therapy (N-SIIT), which can successfully eliminate glucotoxicity with very low risk of hypoglycaemia in type-2 diabetes mellitus (T2DM) patients. The N-SIIT exerted beneficial effects on beta-cell recovery by diminishing glucotoxicity and promoting beta-cell rest. This simple and flexible method adapts to various... Read more
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    14 Feb, 2020
    Sacubitril/valsartan is recommended for patients with heart failure and reduced left ventricular ejection fraction (LVEF). Nevertheless, little is known about its efficacy and safety in cancer therapy-related cardiac dysfunction (CTRCD). A first-ever multicentre study demonstrated that sacubitril-valsartan improved echocardiographic functional and structural parameters, N-terminal pro-B-type... Read more
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    11 Feb, 2020
    A recent study revealed that the incidence of kidney diseases amongst type-1 diabetes mellitus (T1DM) patients was much lesser than the historical estimates. Yet, a minority of the T1DM patients exhibited rapid loss of estimated glomerular filtration rate (eGFR), despite being normoalbuminuric at the beginning of the study. Identification of such decliners though challenging is essential to... Read more
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    07 Feb, 2020
    Brivaracetam is a new antiepileptic drug with limited data in children. A recent study that ascertained the efficacy/tolerability of brivaracetam in pediatric population revealed brivaracetam to be an effective therapy for refractory focal epilepsy in children aged above 4 years. This retrospective chart review was based on data of children/adolescents with refractory epilepsy who were treated... Read more
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    07 Feb, 2020
    The marked seasonal variation in gestational diabetes mellitus (GDM) is not confined only to hot climate regions, stated a recent study. According to the findings, the incidence of GDM as well as that of maternal and neonatal complications varied seasonally even in a relatively cool temperate regions like UK. The incidence of GDM in cool temperate regions was higher during spring months (October... Read more
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    06 Feb, 2020
    The benefits of clopidogrel monotherapy following dual antiplatelet therapy (DAPT) have been less studied in acute myocardial infarction (AMI) patients treated with drug-eluting stents (DES). A recent real-world study demonstrated that amongst AMI patients with DES, clopidogrel monotherapy following uneventful 12-month DAPT yielded similar clinical outcomes as aspirin monotherapy. There was no... Read more
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    06 Feb, 2020
    The aging male patients with benign prostate hyperplasia (BPH) who underwent 120-W Thulium laser enucleation of the prostate were associated with lower postoperative pain and better improvements in the quality of life (QoL) as compared to those who underwent bipolar transurethral resection of the prostate (TURP). The clinical and surgical outcomes, safety and improvements in QoL with 120-W... Read more
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    05 Feb, 2020
    A higher starting dose of basal insulin (0.3 U/kg) can safely and effectively overcome the clinical inertia in overweight/ obese type-2 diabetes mellitus (T2DM) patients who have uncontrolled hyperglycemia despite receiving oral antidiabetics (OADs), stated a first-ever randomized study. Overweight/obese T2DM patients receiving a higher insulin starting dose achieved self-monitored fasting blood... Read more
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    05 Feb, 2020
    Interpersonal problems and depression potentially mediate the high risk of suicide-related behaviors (SRB) and self-harming behavior associated with high intensity usage of mobile phone among adolescents, reported a novel study. This is one of the first studies that determined the association of interpersonal problems and depression and the intensity of mobile phone usage and its influence on... Read more
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    05 Feb, 2020
    A high proportion of obese type-2 diabetes mellitus (T2DM) patients with poorly controlled glycemic control are victims of clinical inertia, reported a recent real-life study. In fact, the glycosylated hemoglobin (HbA1c) remained ≥ 8% for more than a year amongst a substantial proportion of obese T2DM patients being treated with at least two oral antidiabetic agents (ODAs). The time to... Read more
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    03 Feb, 2020
    Initiating antibiotics 1 day prior to onabotulinumtoxin A (BTX-A) injection reduced the risk of urinary tract infection (UTI) in women as compared to those taking antibiotics after BTX-A injection. The researchers of the study recommended that antibiotic prophylaxis prior to the procedure and continuing it for 4 total days would reduce the risk of UTI in women with refractory overactive bladder (... Read more
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    03 Feb, 2020
    Amongst ST-segment elevation myocardial infarction (STEMI) patients, newer P2Y12 receptor inhibitors (prasugrel and ticagrelor) have more favorable in-hospital outcomes as compared to clopidogrel with no compromise on safety concerns. These are the findings from a recent analysis of contemporary European real-world registries that provides a first head-to-head comparison of these three... Read more
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    03 Feb, 2020
    Late-onset sepsis (LOS) with Staphylococcus epidermidis is a frequent finding in preterm infants. Nevertheless, the immunological mechanisms behind this increased susceptibility are not well understood. According to a recent study, impaired cytokine response to S. epidermis precedes LOS. Researchers suggested that quantification of pathogen-specific cytokine responses at day 7 may identify... Read more
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    03 Feb, 2020
    Coronavirus is a large family of viruses that causes illnesses ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). First case of infection with a novel new type of Coronavirus (novel Coronavirus, 2019-nCoV) was reported in Wuhan City, Hubei Province in China. Spread to various parts of China, and later... Read more