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    19 Oct, 2018
    Rising environmental temperature in the 3–4 weeks rather than a daily temperature change prior to oral glucose tolerance testing (OGTT) in pregnant females may be associated with beta cell dysfunction and an increased risk of gestational diabetes mellitus (GDM), stated a recent study. Increase in temperature few weeks prior to OGTT was thus associated with increased risk of GDM. However,... Read more
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    19 Oct, 2018
    The recently published “Improve Clinical Outcomes in high-risk patieNts with acute coronary syndrome” (ICON-1) study demonstrated invasive revascularization to be feasible and well-tolerated in geriatric population affected with non-ST-elevation acute coronary syndrome (NSTEACS), regardless of their frailty status.  Nevertheless, at One-year, frailty was associated with adverse... Read more
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    19 Oct, 2018
    The 30, 60 and 90 days hospital readmissions were significantly reduced after implementation of the discharge care bundle in patients admitted for acute exacerbations of chronic obstructive pulmonary disease (AECOPD), concluded a study presented at the recent annual CHEST meeting. The COPD discharge care bundle did not increase the length of hospital stay, added the researchers of the study. The... Read more
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    17 Oct, 2018
    The results of a prospective study in Denmark concluded that the use of contemporary combined hormonal contraceptives was associated with a reduced risk of ovarian cancer in women of reproductive age. This pattern was similar to those seen with older combined oral products. The reduced risk diminishes after stopping use. The study could not confirm the similar protective effect from progestogen-... Read more
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    17 Oct, 2018
    Recently a randomized, open-label study was conducted in healthy volunteers, to understand the effect of the tenofovir alafenamide (TAF)-based antiretroviral combination therapies (fixed-dose combinations (FDCs) of tenofovir alafenamide/ emtricitabine (F/TAF), tenofovir alafenamide/emtricitabine/elvitegravir/cobicistat (E/C/F/TAF), or tenofovir alafenamide/emtricitabine/rilpivirine (R/F/TAF) on... Read more
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    17 Oct, 2018
    The patients undergoing radiotherapy for prostate cancer were at an increased risk of developing rectal cancer compared with patients unexposed to radiation, reported a recent meta-analysis  However, radiotherapy did not increase the risk of colon cancer. The meta-analysis further determined that brachytherapy had no association with second rectal cancer or colon cancer. A total of 16... Read more
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    16 Oct, 2018
    A recent analysis determined the association between seasonal light exposure, categorized by type of day length and perinatal and postpartum depression. The results showed that women who were in their third trimester during the period when days were shortening (August to first 4 days of November), had higher depressive symptom scores as compared to women in the other day length category.... Read more
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    16 Oct, 2018
    Researchers recently assessed the proportion of comorbidities in patients with dry eye disease (DED) as compared to controls (matched subjects without DED). The results revealed that a substantially higher proportion of DED patients suffered with an array of comorbidities such as; hypertension, cataracts, thyroid disease, type-2 diabetes, and glaucoma as compared to controls. Subsequently, DED... Read more
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    16 Oct, 2018
    The European Medicines Agency (EMA) has issued a precautionary advice on HIV medicine Dolutegravir following the preliminary results of a study conducted in 11,558 HIV infected women in Botswana. Birth defects such as spina bifida were reported in 4 babies born to mothers after taking dolutegravir. The incidence of neural birth defects was 0.9% in the babies born to mothers who took dolutegravir... Read more
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    16 Oct, 2018
    Familial multiple sclerosis (MS) might have a more aggressive course as compared to sporadic MS, suggested a recent study. In fact, patients with familial MS not only had an early onset but also had a more severe course as compared to their counterparts affected with sporadic MS, reported the study. Also, parents with familial MS had a higher annualized relapse rate within the first 5 years of... Read more
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    16 Oct, 2018
    A recent case-control study assessing different detection thresholds for pretreatment drug resistance to predict an increased risk of virological failure on first-line non-nucleoside reverse transcriptase inhibitors (NNRTI)-based  antiretroviral therapy (ART) suggested that use of ultrasensitive resistance testing for pretreatment drug resistance increased  sensitivity i.e... Read more
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    16 Oct, 2018
    Sodium-glucose co-transporter (SGLT) 2 inhibitors have a beneficial renal impact in type-2 diabetes mellitus (T2DM) patients with co-existing chronic kidney disease (CKD), reported a recent Japanese study. According to the findings such T2DM patients with macro- and microalbuminuria had a reduction in their albumin-creatinine ratio (ACR) after being treated with SGLT2 inhibitors. T2DM patients... Read more
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    16 Oct, 2018
    Recently published DAPT-STEMI trial demonstrated that six months dual antiplatelet therapy (DAPT) was non-inferior to DAPT for 12 months in ST-segment elevation myocardial infarction (STEMI) patients who remain event-free at six months following primary percutaneous coronary intervention (PCI) performed with second generation drug-eluting stents.... Read more
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    15 Oct, 2018
    Switch and swap can be currently considered as alternative suitable approache in rheumatoid arthritis (RA) patients failing TNF inhibitors (TNFis), according to the results of a recent modified Italian Expert Consensus that targeted to introduce an evidence-based and experts opinion filtered statements on the optimal treatment choice between cycling (switch) and changing mode of action strategies... Read more
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    15 Oct, 2018
    A recent prospective multi-center study evaluating the rates of surgical site infection (SSIs) with the use of the novel surgical device that combines barrier surgical wound protection and continuous surgical wound irrigation in patients undergoing colorectal surgery showed 61% reduced SSIs rates when compared with predicted rates of SSIs. The SSI... Read more