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    11 May, 2020
    Researchers recently ascertained the efficacy, safety, and immunogenicity of a live attenuated tetravalent dengue vaccine (TAK-003) in healthy children aged 4-16 years. The study found TAK-003 to be well tolerated and efficacious against symptomatic dengue in children irrespective of their serostatus before immunization. The fact that the... Read more
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    08 May, 2020
    A recent community-based study conducted in China compared the prevalence of diabetic retinopathy (DR) and diabetic macular edema (DME), as well as their risk factors in patients with early onset diabetes (EOD, ≤40 years) and late onset diabetes (LOD, >40 years).The study showed that the prevalence of DR and DME were apparently higher in patients who developed diabetes ≤40 years of age... Read more
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    08 May, 2020
    A recent study demonstrated a greater prevalence of depression and suicidality in adolescents affected with allergic rhinitis (AR). Adolescents with AR, especially those with identifiable risk factors may thus require a multidisciplinary approach including psychological support to prevent suicide, according to the researchers. Researchers analyzed the data from annual Korea Youth Risk Behavior... Read more
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    08 May, 2020
    PROfound trial is a prospective, biomarker selected, phase 3 trial involving men with metastatic castration-resistant prostate cancer who had disease progression while receiving a new hormonal agent (e.g. Enzalutamide or abiraterone). Recent findings from this study suggested that imaging-based progression-free survival was significantly longer in the olaparib group than in the control group... Read more
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    08 May, 2020
    Findings from a recent case-control study examining the relationship between systemic hypertension (HTN) and primary open angle glaucoma (POAG) using Taiwan’s nationwide health insurance claims data suggested that POAG was significantly associated with pre-existing hypertension. The study found that 56.49% of patients had prior hypertension and the prevalence of prior hypertension was... Read more
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    08 May, 2020
    Amongst heart failure (HF) patients, baseline N-terminal pro-B type natriuretic peptide (NT-proBNP) level predicts HF events but does not alter the sacubitril/valsartan treatment impact in patients with heart failure with preserved ejection fraction (HFpEF), according to a recent analysis of the PARAGON HF trial (Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in... Read more
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    07 May, 2020
    A first-ever study provided real-world evidence on the cardiovascular (CV) benefits of novel antidiabetic medications prescribed to type-2 diabetes mellitus (T2DM) patients. According to the findings, both sodium glucose cotransporter-2 inhibitors (SGLT-2is) and glucagon like peptide-1 receptor agonists (GLP-1 RAs) significantly reduced the composite outcome [myocardial infarction (MI), stroke,... Read more
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    07 May, 2020
    Recently, a retrospective survey was conducted to evaluate the changing clinical trends and practices concerning bariatric and metabolic surgery in India in the last 5 year. According to the study, laparoscopic sleeve gastrectomy (LSG) continued to remain the most popular procedure followed by laparoscopic one anastomosis gastric bypass (OAGB/MGB). Laparoscopic Roux-en y gastric bypass (RYGB) is... Read more
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    07 May, 2020
    Administration of a single post-operative subcutaneous injection of omalizumab at 2 weeks after endoscopic sinus surgery for allergic fungal rhinosinusitis (AFRS) was associated with better clinical and endoscopic outcomes than twice daily intranasal steroid spray. Treatment with omalizumab resulted in significantly better control of symptoms as well as improvement in endoscopic follow-up. Both... Read more
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    07 May, 2020
    A recent study demonstrated that use of antidepressant medication for non-psychiatric disorders such as migraine prophylaxis did not increase the risk of tardive dysphoria. The findings however indicated that antidepressants may lead to habituation or tachyphylaxis, such that their continuation and subsequent withdrawal could lead to new onset of depressive symptoms even when used for other... Read more
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    07 May, 2020
    Patients with Parkinson’s disease (PD) have a high risk of fractures right from the prodromal period (5 years before the disease diagnosis), reported a recent large-scale study. In fact, the risk of fractures (primarily due to fall) increased as diagnosis date of PD approached. These findings hint that patients with PD may experience unrecognized motor and nonmotor symptoms that... Read more
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    06 May, 2020
    The use of ceftriaxone in combination with metronidazole might offer superior outcomes than ceftriaxone alone or co-amoxiclav in the management of periorbital cellulitis secondary to sinonasal infections, concluded a study carried out at 8 centers in UK. The adjuvant use of intranasal decongestants and corticosteroids might reduce the need for surgical intervention. Periorbital cellulitis is a... Read more
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    06 May, 2020
    Multiparametric magnetic resonance imaging (mpMRI) for the detection of clinically significant prostate cancer (csPCa) is currently recommended as the first-line investigation in the European Association of Urology (EAU) guidelines. A recent study compared and evaluated mpMRI targeted biopsy (TBx) strategy, contrast ultrasound dispersion imaging (CUDI)-TBx strategy and systematic biopsy (SBx)-... Read more
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    06 May, 2020
    Some patients with neovascular age-related macular degeneration (AMD) have persistent exudation despite frequent injections and may be considered suboptimal responders to anti-vascular endothelial growth factor (VEGF) therapy.  Recently, a randomized controlled study compared the short-term effects of topical dorzolamide-timolol vs placebo in eyes with neovascular AMD that have persistent... Read more
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    06 May, 2020
    Children who develop coeliac disease (CD) are believed to be victims of impaired growth. A recent study revealed that the growth of children at risk of CD rarely falls below 'clinical standards'. Nevertheless, infants with CD had a significantly lower growth rate as compared with controls. The findings point towards peculiar compromised pathways of ... Read more