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    31 Mar, 2020
    Subcutaneous inclisiran injections at day 1, 90 and then every six months can bring about substantial reductions in low-density lipoprotein cholesterol (LDL-C) in patients with elevated LDL-C levels. These are the findings of a recent study that analyzed the data of ORION-10 and ORION-11 trials. In fact the patients treated with inclisiran every six months had a 50% reduction in LDL-C levels. The... Read more
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    31 Mar, 2020
    Dry eyes are commonly seen in normal population, affecting 5% to 34% of the population around the world. It may be triggered by environmental factors associated with low-humidity ambient, use of contact lenses, excessive use of computers, etc. Recently, a case-control study compared the prevalence and severity of dry eyes syndrome among Brazilian patients with DM and normal population.... Read more
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    31 Mar, 2020
    Atopic dermatitis (AD) is a chronic inflammatory skin condition affecting 15-30% of children worldwide. Moisturizers and topical corticosteroids (TCS) are the 84 mainstay of therapy for atopic dermatitis (AD), but studies on best bathing practices, including bathing frequency, in the management of pediatric AD are limited.  However, AD guidelines remain inconsistent. Parents of children with... Read more
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    31 Mar, 2020
    A real-world study that analysed data from the EPICOR Asia study reaffirmed that many patients with acute coronary syndrome (ACS) underwent percutaneous coronary intervention (PCI) and continued receiving dual antiplatelet therapy (DAPT) for two years post-discharge, irrespective of the index event. Various factors that predicted mortality in the study subjects were also identified. The findings... Read more
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    31 Mar, 2020
    A recent study demonstrated a gradual improvement in the functional beta-cell capacity in type-2 diabetes mellitus (T2DM) patients who had achieved diabetes remission due to weight loss. In fact, the functional beta-cell capacity in these patients improved to match that of nondiabetic control (NDC) subjects by one year and remained unchanged at two years in those who remained in T2DM remission... Read more
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    31 Mar, 2020
    Ixekizumab is a monoclonal antibody that selectively targets interleukin-17A. It is approved for the treatment of moderate-to-severe plaque psoriasis. Recently, researchers assessed its long-term efficacy and safety in the treatment of moderate-to-severe plaque psoriasis.  The five-year results showed 100% improvement in psoriasis severity (Psoriasis Area and Severity Index 100). Moreover,... Read more
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    27 Mar, 2020
    Postprandial glycemia is a known risk factor for diabetes and cardiovascular disease. A recent study demonstrated that the sequence of food consumption with rice based meal had a significant impact on postprandial glucose, insulin and incretin response without affecting satiety in healthy individuals. Eating vegetables and protein before carbohydrate is a simple and novel eating strategy to curb... Read more
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    27 Mar, 2020
    A first-of-its kind study conducted in pediatric patients demonstrated that children with epilepsy and with acquired demyelinating disorders of the central nervous system (CNS) had significantly higher serum α-synuclein levels as compared with their healthy counterparts. Importantly, these increased α-synuclein levels correlated with measures of disease severity. The study further reported serum... Read more
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    26 Mar, 2020
    The impact of antihypertensive combination therapy on the risk of hypokalemia is unclear as of now. A recent study revealed hypokalemia to be a common finding in hypertensive patients treated with combinations of various antihypertensive medications. Patients who received thiazide diuretics in combination with calcium channel blockers (CCB), renin angiotensin system inhibitors (RASi), or beta-... Read more
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    26 Mar, 2020
    A simple magnetic resonance imaging (MRI) score based on visual rating can be used in routine clinical practice to predict the risk of dementia and cognitive decline for patients with cerebral small vessel disease (SVD), reported a large-scale study. Researchers ascertained whether a simple score based on rapid visual assessment of clinical MRI scans would predict the risk of cognitive decline... Read more
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    24 Mar, 2020
    The existing data with respect to prenatal antibiotic exposure and mode of delivery increasing the risk of wheezing in infants and toddlers are varying. A recent study suggested that children born by Cesarean sections may be more susceptible to infectious wheezing. The study however, found no association between prenatal antibiotic exposure and wheezing types. This study was conducted to... Read more
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    20 Mar, 2020
    Late-onset sepsis due to coagulase-negative staphylococci (CoNS) is frequent in preterm infants. Although vancomycin is the first-line therapy, emergence of vancomycin-resistant strains has led to increased use of linezolid. Nevertheless, currently little is known about the long-term safety of linezolid in preterm infants.  A recent study revealed that linezolid exposure did not... Read more
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    20 Mar, 2020
    With the increasing use of continuous glucose monitoring (CGM), time in range (TIR) and other CGM metrics have now emerged as the core metrics for clinical targets and assessing diabetic complications, beyond glycosylated haemoglobin (HbA1c). A recent study demonstrated that amongst type-2 diabetes mellitus (T2DM) patients, TIR 70-180 mg/dL and... Read more
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    20 Mar, 2020
    It is not known whether discontinuation of renin-angiotensin system blockade when estimated glomerular filtration rate (eGFR) falls below 30 mL/min/1.73 m2 is linked to the risk of all-cause mortality, major adverse cardiovascular events (MACE), and end-stage kidney disease (ESKD) in the subsequent 5 years.  A recent large-scale real-world study demonstrated that discontinuation of... Read more
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    20 Mar, 2020
    Various ophthalmologic symptoms are frequent yet under-reported in Parkinson’s disease patients. Majority of these visual impairments are treatable hence their timely recognition is crucial amongst PD patients. A recent study reaffirmed a higher prevalence of ophthalmologic symptoms in PD patients as compared to controls. Importantly, the ophthalmologic symptoms interfered considerably in... Read more