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    10 Oct, 2019
    Efavirenz (EFV) plus tenofovir and emtricitabine (or lamivudine) is the recommended regimen for first-line antiretroviral treatment. However, it has been suggested that it can continue to exert a neurotoxic effect and impair patient neurocognitive (NC) function, even in the absence of clearly reported symptoms. A recent randomized control trial assessed whether switching to rilpivirine (RPV)... Read more
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    10 Oct, 2019
    Several studies have demonstrated that inpatient hyperglycemia (with or without a prior diagnosis of diabetes) is associated with an increased risk of complications. Currently, data on use of oral antidiabetic (OAD) during hospitalization are limited. A recent study revealed that during hospitalization, patients with certain characteristics could achieve an acceptable level of glycemic control... Read more
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    10 Oct, 2019
    A recent study revealed that nearly 28% of acute myocardial infarction (AMI) patients [with ST-segment elevation (STEMI)] underwent primary percutaneous coronary intervention (pPCI) beyond the guideline recommended timelines (>120min from diagnostic ECG). As predicted these patients have poorer five-year outcomes when compared with patients receiving a pharmacoinvasive strategy... Read more
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    09 Oct, 2019
    A recent study that determined the association between white matter hyperintensities (WMH), structural brain network integrity, and post-stroke aphasia severity, demonstrated a significantly stronger association between WMH and damage to a higher percentage of long-range fibers rather than mid- and short-range fibers. In fact, WMH resulted in worse aphasia in chronic stroke by affecting higher... Read more
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    09 Oct, 2019
    Acne vulgaris is often treated with topical or systemic therapies according to severity. Photodynamic therapy (PDT) with topical delta-aminolevulinic acid is a novel drug sparing, but time-consuming approach. sunlight exposure has been considered a quicker, safer, cheaper and more agreeable alternative light source for PDT, but efficacy has only been proven in the oncological field. A recent... Read more
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    09 Oct, 2019
    Suprapubic hernia is a special type of incisional hernia in the hypogastrium. The optimal choice of surgery for this condition is controversial.  Recently researchers evaluated the novel laparoscopic surgery procedure for suprapubic incisional hernia repair: the enhanced transabdominal preperitoneal (ETAP) technique in patients who underwent suprapubic incisional hernia. The study found that... Read more
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    09 Oct, 2019
    Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) are emerging contaminants that have been widely detected in aquatic environment. Wastewater treatment plants (WWTPs) are an important mode of urban water cycle, are considered as reservoirs of antibiotics, ARB and ARGs from hospital, veterinary and agriculture. A recent study investigated the evolution of antibiotic... Read more
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    09 Oct, 2019
    Patients with end-stage abdominal-wall failure represent one of the most complex groups of reconstructive challenges. Despite performing a transversus abdominis release (TAR), anterior fascial re-approximation is not feasible and a bridged repair is required. A recent retrospective study assessed the outcomes in Cleveland Clinic patients who had an elective open ventral hernia repair using the... Read more
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    09 Oct, 2019
    DolPHIN-1 (Dolutegravir in pregnant HIV mothers and their neonates) is an open-label randomised trial of dolutegravir (DTG) compared with efavirenz (EFV)-based standard-of care antiretroviral treatment (ART) in women presenting with untreated HIV in the third trimester of pregnancy.  Recent results of the study showed superior virological suppression with DTG compared to efavirenz among... Read more
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    09 Oct, 2019
    Amongst patients suffering with moderate dry eye disease (DED), those treated with a combination of topical loteprednol and cyclosporine (Cs) had a significantly better alleviation of symptoms and signs of DED vs. their counterparts receiving only Cs, reported a recent Indian study. Substantial proportion on Indian population suffers with DED. Studies have demonstrated a central role of tear... Read more
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    04 Oct, 2019
    Dual antiplatelet therapy (DAPT) beyond 12 months does not reduce the risk of major cardiovascular and cerebrovascular events (MACCE) as compared with 12-month DAPT amongst acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI) with second generation drug eluting stents (DES), stated a recent real-world study. The study did not find... Read more
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    04 Oct, 2019
    Pediatric patients with neurogenic bladder (NGB) have an elevated albumin-creatinine ratio (ACR), despite normal estimated glomerular filtration (eGFR), reported a recent study. The study further highlighted the elevated risk of hydronephrosis (HN) and vesicoureteral reflux (VUR) in such patients with albuminuria, cautioning on their elevated risk of progressive renal disease. Neurogenic bladder... Read more
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    04 Oct, 2019
    A recent study identified patient characteristics and treatment strategies associated with success and failure of glycemic control in type-2 diabetes mellitus (T2DM) patients after they decline initiation of insulin therapy as recommended by their clinicians. Discontinuation of non-insulin antidiabetic medications was the main reasons for worsening of glycemic control in patients who declined... Read more
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    03 Oct, 2019
    Differences in tremor pathophysiology may be the reason behind the interindividual clinical differences in dopamine response of Parkinson’s disease (PD) rest tremor, reaffirmed a recent study. According to the findings, PD patients with dopamine-resistant tremor had increased tremor amplitude-related activity in the cerebellum (lobules IV/V/IX and cerebellar nuclei, particularly the... Read more
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    03 Oct, 2019
    Otoscopy was always used by 96% of the general practitioners (GPs) and specialist trainees in primary care (STs) at 27 primary health care centers in Sweden for the diagnosis of acute otitis media (AOM). Written advice was provided more frequently by the female GPs and STs as compared to their male colleagues. Otomicroscopy was used more often by the GPs than STs. The researchers of this study... Read more