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    05 May, 2020
    A recent large-scale study revealed that in patients with left ventricular (LV) thrombi, direct oral anticoagulant (DOAC) treatment was associated with a higher risk of stroke and systemic embolism (SSE) as compared with warfarin use, even after adjusting for various confounders. The findings not only put the current assumption of DOAC equivalence with warfarin for treating LV thrombi under... Read more
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    05 May, 2020
    A recent study evaluated the long-term outcomes in the largest cohort of patients consecutively treated with lenalidomide, bortezomib, and dexamethasone (RVD) induction therapy followed by risk-adapted maintenance therapy with the longest follow-up. The study showed high response rates (very good partial response or better) in 90% of patients treated with RVD induction regimen after... Read more
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    05 May, 2020
    Vitamin D deficiency may have a role in the pathogenesis of acne and vitamin D supplementation may improve acne lesion has been reported in few studies.  Recently, a study investigated the serum 25-OH vitamin D levels in acne patients and identified their relationship with disease severity in a larger study group. The study found that in acne patients, serum 25-OH vitamin D levels... Read more
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    04 May, 2020
    Current clinical practice in wound care involves the application of multiple and distinct delivery systems that lead to the variability of dose and poor control of local concentrations. A recent study assessed the manufacturing feasibility, structural architecture and potential therapeutic efficacy of the portable trilayered system in which two drugs are used in treatment of wounds may be... Read more
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    04 May, 2020
    Femtosecond technology has brought new surgical methods for refractive surgeries: femtosecond laser-assisted LASIK (FSLASIK), and femtosecond laser small incision lenticule extraction (SMILE). Long-term postoperative quality of life and satisfaction differences between SMILE and FS-LASIK for myopia correction was assessed in a recent cross-sectional study. The study reported no significant... Read more
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    04 May, 2020
    The findings of a recent case-control study demonstrated that maternal exposure to bisphenol A (BPA) and n-propyl paraben (n-PrP) during early gestation might have adverse male genital developmental outcomes. A positive correlation was observed between maternal serum BPA concentration at 10–17 weeks of gestation and congenital or postnatally acquired cryptorchidism. Similarly,... Read more
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    04 May, 2020
    Risk of postoperative complications in Crohn's disease (CD) patients is generally greater compared to non-CD patients. Recently, an observational retrospective study compared the early major complications rates between CD and colon cancer (CC) patients undergoing mini-invasive ileo-colic resections or right hemicolectomies and evaluated the role of pre-operative medication with anti-TNF as a... Read more
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    04 May, 2020
    A recent study demonstrated that among general medicine and surgery patients with type-2 diabetes mellitus (T2DM), treatment with dipeptidyl peptidase-4 inhibitor (DPP4-i) alone or in combination with basal insulin was effective and was associated with lower incidence of hypoglycemia when compared to a basal bolus insulin regimen. The study further indicated that the efficacy of DPP-4i in... Read more
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    30 Apr, 2020
    Results of a recent, randomized phase 3 trial comparing a standard bevacizumab-containing regimen versus carboplatin–pegylated liposomal doxorubicin combined with bevacizumab in recurrent ovarian cancer showed that carboplatin– pegylated liposomal doxorubicin–bevacizumab regimen led to longer progression-free survival than the carboplatin–gemcitabine–bevacizumab... Read more
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    30 Apr, 2020
    A recent retrospective study demonstrated a twofold increase in the risk of small for gestational age (SGA) in women with endometrial thickness (EMT) < 7.5 mm compared to women with EMT >12 mm undergoing fresh in vitro fertilization/intracytoplasmic sperm injection–embryo transfer (IVF/ICSI–ET) cycles. The researchers suggested improved prenatal care in case of women with a... Read more
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    30 Apr, 2020
    An ad-hoc subcommittee of the American Thoracic Society (ATS) assembly on clinical problems developed this guideline after a rigorous population, intervention, comparator and outcomes (PICO)-driven distillation of the scientific evidence. The task force made recommendations related to the key questions on the pharmacologic treatment of chronic obstructive pulmonary disease (COPD). However, more... Read more
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    30 Apr, 2020
    A recent study revealed distinct signatures in the spatial networks of functional connectivity that emerge during successful anesthetic liberation in status epilepticus. Patients with failed anesthetic weaning lacked these features. Researchers believe that identification of distinct features that emerge during successful anesthetic weaning may allow faster and more successful anesthetic... Read more
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    30 Apr, 2020
    Diagnosis of internal hernia (IH) may be difficult in patients undergone laparoscopic Roux-en-Y gastric bypass (LRYGB), due to non-specific symptoms ranging from intermittent chronic abdominal to acute abdomen pain. According to a recent study, evaluating the accuracy of CT in diagnosing IH and differentiating it from non-specific abdominal pain, CT scan performed by experienced radiologists... Read more
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    29 Apr, 2020
    Hypokalemia during hospitalization is not associated with short-term or long-term clinical outcomes in elderly patients hospitalized for worsening heart failure (HF). These findings from a recent study propose that the association between hypokalemia and clinical outcomes may be heterogeneous in HF patients; varying with the patient characteristics. A strict target of serum potassium ≥4.0 mmol... Read more
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    29 Apr, 2020
    A 6-month dose of 0.20 U/kg/day of basal insulin (BI) results in effective glycemic control in type-2 diabetes mellitus (T2DM) patients, reported a recent post-hoc analysis of the ORBIT registry. The study further identified the important patient characteristics that significantly predicted the dose of BI in real-world setting. Randomized clinical trials have already established the efficacy of... Read more