• 0
    29 Apr, 2020
    Results of a cross-sectional analysis on middle-aged women obtained from the Study of Women’s Health Across the Nation (SWAN) revealed that menopause is recently evolved and ongoing evolving trait. There was a significant broad window of variation in age at menopause within the five ethnic populations and absence of significant differences between populations, in combination with population... Read more
  • 0
    28 Apr, 2020
    Individuals living in areas with higher levels of ambient air pollutants have lower cognitive scores and more rapid rates of cognitive decline over time, reported a recent study. Researchers had included two cohorts in the US; the Washington Heights–Inwood Community Aging Project (WHICAP) and the Northern Manhattan Study (NOMAS). The association between air pollutants and cognitive function... Read more
  • 0
    28 Apr, 2020
    Certolizumab Pegol (CZP) is a polyethylene glycol (PEG) PEGylated, Fc-free tumour necrosis factor-α inhibitor approved for the treatment of psoriatic arthritis (PsA) beyond that rheumatoid arthritis, axial spondyloarthritis/ankylosing spondylitis, and Crohn’s disease. Recently researchers evaluate the efficacy and safety of CZP monotherapy, in small psoriasis (PsO) in patients affect both... Read more
  • 0
    28 Apr, 2020
    The United States of Food and Drug Administration (FDA) approved combined use of ibrutinib with rituximab for the initial treatment of adult patients with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). The approval was based on the findings from a randomized, multicentre, open-label, actively controlled study that compared ibrutinib with rituximab to fludarabine,... Read more
  • 0
    28 Apr, 2020
    As per the current US prescribing information, prescribing changes with dabigatran and P-gp inhibitors are recommended only in patients with lower kidney function. One of the first real-world studies reported that in nonvalvular atrial fibrillation (NVAF) patients having normal kidney function, coprescription of dabigatran with the P-gp inhibitors verapamil or diltiazem was associated with an... Read more
  • 4
    28 Apr, 2020
    Findings of a recent meta-analysis demonstrated that inhaled tiotropium did not increase the risk of cardiovascular events, all-cause mortality and cardiovascular mortality in patients with chronic obstructive pulmonary disease (COPD). Additionally, the risk of adverse cardiovascular events did not corelate with the duration of tiotropium treatment. Although tiotropium is often used as a first... Read more
  • 0
    27 Apr, 2020
    Intravenous magnesium was simple, inexpensive and effective in reducing the incidence of catheter-related bladder discomfort with high patient satisfaction among patients having transurethral resection of bladder tumor.  Results of a recent randomized study concluded that magnesium significantly reduced the bladder discomfort related to catherization with a number needed to treat of only 2... Read more
  • 0
    27 Apr, 2020
    In patients with psoriasis, tumour necrosis factor inhibitor (TNFi) treatment increases the risk of new-onset TB infection and reactivation of latent TB infection (LTBI). VOYAGE 1 and VOYAGE 2 are two phase 3 studies that established superior efficacy of guselkumab versus adalimumab (TNFi) in patients with moderate-to-severe psoriasis. Recently, researchers used pooled data from these two trials... Read more
  • 0
    27 Apr, 2020
    Anthracycline- and taxane-based therapy are regarded as the standard adjuvant chemotherapy for triple-negative breast cancer (TNBC). A recent randomized phase III trial compared efficacy and safety of adjuvant capecitabine in combination with docetaxel and cyclophosphamide plus epirubicin for patients with early TNBC. The study showed that capecitabine added to standard adjuvant chemotherapy... Read more
  • 0
    27 Apr, 2020
    The “metformin usage index” (MUI) can serve as a risk assessment tool for evaluating vitamin B12 deficiency in patients with type-2 diabetes mellitus (T2DM), reported a large Indian study. According to the findings, the prevalence of vitamin B 12 deficiency was high among T2DM patients with MUI >5, with the risk being highest amongst those with MUI >15. In resource-poor settings... Read more
  • 2
    24 Apr, 2020
    Individuals consuming five or more servings of alcoholic beverages per day are burdened with a high risk of headache the following day. These are the findings of a recent study that determined the association between alcohol intake and occurrence of headaches on the following day. Nevertheless, one-two servings of alcoholic beverages were not associated with risk of headaches the following day.... Read more
  • 0
    24 Apr, 2020
    Rapid changes in the circulating leukocyte and erythrocyte counts were inhabited by cetirizine, highlighting the pharmacological effects of antihistamines in IgE mediated inflammatory responses in allergic rhinitis (AR). The results of this study showed that cetirizine diminished gender-specific changes in lymphocytes, monocytes and eosinophil dynamics on allergen exposure. Overall, cetirizine... Read more
  • 0
    24 Apr, 2020
    A recent study identified 14 differentially-expressed proteins (DEPs) amongst psychotropic drug-free patients affected with major depressive disorder (MDD) and bipolar disorder (BD). Ras-related protein (RAB7A), Rho-associated protein kinase 2 (ROCK2), and Exportin-7 (XPO7) were the potential peripheral protein candidates that could distinguish between MDD and BD. Major depressive disorder and... Read more
  • 0
    24 Apr, 2020
    Findings from a recent randomized clinical trial evaluating the efficacy of topical corticosteroids in treating herpes simplex stromal keratitis showed that topical corticosteroid regimen was significantly better than placebo in reducing persistence or progression of stromal inflammation and in shortening the duration of herpes simplex stromal keratitis. Researchers noted a 68% reduction in risk... Read more
  • 3
    24 Apr, 2020
    High-dose inhalation budesonide (BUD) could be beneficial in not only minimizing the worsening of asthma and hospitalization rate, but also improving the pulmonary functions in pediatric patients. Inhalation BUD was found to be safe with negligible adverse drug reactions, confirmed the results of a meta-analysis. This systematic review and meta-analysis assessed the benefits of BUD on the... Read more