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    07 Apr, 2020
    Cryptococcus neoformans (C. neoformans) is the most common cause of meningitis among HIV-seropositive adults in sub- Saharan Africa. Fluconazole, in combination with amphotericin B, is recommended for induction treatment of cryptococcal meningitis and as monotherapy for consolidation and maintenance treatment. Recently a study was conducted to determine fluconazole minimum inhibitory... Read more
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    07 Apr, 2020
    The conception rate, per-cycle and cumulative pregnancy outcomes in young patients aged <35 years with diminished ovarian reserve were similar to those of age-matched controls after intrauterine insemination (IUI) irrespective of treatment strategy, concluded a recent study. This single-center retrospective study compared the pregnancy outcomes following IUI in young women with diminished... Read more
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    07 Apr, 2020
    Vildagliptin, a dipeptidyl peptidase (DPP)-4 inhibitor is effective and safe for the treatment of type 2 diabetes mellitus (T2DM). Nevertheless, its long-term safety, effectiveness, and clinical relationship with cardiovascular events have not been evaluated in-depth in Asians. A recent real-world study conducted in Japan demonstrated vildagliptin... Read more
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    07 Apr, 2020
    B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are used widely for screening heart failure (HF). A first ever systematic review ascertaining the utility of natriuretic peptide for HF screening in nursing home population hinted that the current screening cut-off values were probably too low for screening nursing home population. Cut-off values of 230... Read more
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    06 Apr, 2020
    Diabetic retinopathy (DR) is a well-known complication of diabetes and the leading cause of blindness among working-age adults. Early diagnosis and treatment of DR can prevent blindness, but many people with this condition are not diagnosed early enough to be treated effectively. Screening programs have reduced the risk of sight loss among people with diabetes. However, the consensus among... Read more
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    06 Apr, 2020
    The LACE+ (Length of stay, Acuity of admission, Charlson Comorbidity Index score, and Emergency department visits in the past six months) is a risk-prediction tool for orthopaedic surgery outcomes. However, it is never evaluated in an orthopaedic surgery population. A recent retrospective study assessed its utility risk-prediction for   30D orthopaedic surgery outcomes. The study showed... Read more
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    06 Apr, 2020
    The 2019 GINA strategy report represents the most significant change in asthma management in over 30 years. The 2019 GINA report includes important new recommendations for treatment of mild asthma and severe asthma. The Long-Term Goals of Asthma Management are: To achieve good control of symptoms and maintain normal activity levels To minimize future risk of exacerbations, fixed airflow... Read more
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    03 Apr, 2020
    A recent study found no evidence on role of daily emollient in preventing eczema in high-risk children during the first year of life. In fact, some evidence hinted towards increased risk of skin infections. Researchers recommend that families with eczema, asthma, or allergic rhinitis should not use daily emollients with an intention to prevent eczema... Read more
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    03 Apr, 2020
    A substantial proportion of diabetes mellitus patients suffer with major depressive disorder (MDD), reported a recent Indian study. MDD was associated with poorly controlled fasting blood glucose in study subjects probably hinting towards its clinical relevance to improve glycemic control, reduce complications and improve the quality of life in the patient. The association between diabetes and... Read more
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    03 Apr, 2020
    Opening wedge HTO (OW) performed with the development of rigid plate fixator have demonstrated good mid- to long-term clinical outcomes. The long-term results of HTO mainly depend on postoperative alignment, the accuracy of the correction is crucial. In a recent study, researchers assessed the early postoperative loss of achieved correction and associated factor after opening wedge high tibial... Read more
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    02 Apr, 2020
    Women with gestational diabetes mellitus (GDM) and abnormal fasting blood glucose (FBG) are burdened with a high risk for large for gestational age (LGA) neonates, reported a recent study. The study further revealed that amongst women with GDM, combined abnormal fasting and post-load blood glucose values were associated with increased risk for insulin therapy. Nearly half of the pregnant women... Read more
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    02 Apr, 2020
    A recent prospective study evaluated conjunctival surface cells and tear-film functions in cases with vitamin D deficiency. Results showed that tear break-up time and Schirmer II test values in the study group were 11s and 7.5 mm compared to 17s and 12mm in the control group. Moreover, the conjunctival impression cytology tests showed that 69% of patients in the study group and 18.5% 9n control... Read more
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    02 Apr, 2020
    A recent study demonstrated that amongst patients presenting with stable chest pain, low-attenuation noncalcified plaque burden [as identified by coronary CT angiography (CCTA)] was the most robust predictor of fatal/nonfatal myocardial infarction (MI) as compared to cardiovascular (CV) scores, coronary calcium score or coronary artery stenosis severity. Patients with a low-attenuation plaque... Read more
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    02 Apr, 2020
    A recent study demonstrated a higher risk of epilepsy in children and youths with celiac disease (CD) when compared to their healthy counterparts. The findings suggest that epilepsy patients without a clear etiology should be screened for CD.  Early diagnosis and treatment of CD might improve the response to antiepileptic treatment, according to the researchers. This study was... Read more
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    02 Apr, 2020
    Spontaneous intracerebral hemorrhage (ICH), a progressive cause of morbidity and mortality has been considered as an orphan disease until now. Research has identified perihematomal hypodensity (PHHD) as an attractive treatment target. A recent study demonstrated that early antihyperthermic treatment in patients with spontaneous ICH with a basal axillary temperature ≥37.5°C was associated... Read more