A substantial proportion of type-2 diabetes mellitus with chronic kidney disease (CKD) have a rapid progression of CKD. Prompt identification of this high-risk subgroup is critical to address their unmet therapeutic needs.
This study is the first randomized, controlled trial in an antiretroviral-naive population that evaluated the efficacy of reduced doses of both tenofovir disoproxil fumarate (TDF) and efavirenz (EFV) for the treatment of HIV-1 infection. This 48-week study showed that lower doses regimen of both TDF and EFV was non-inferior to the standard dose regimen of TDF 300 mg plus lamivudine (3TC) 300 mg, and EFV 600 mg.
The present study describes the outcomes of endoscopic vacuum therapy (E-VAC) as a rescue treatment in refractory anastomotic leak and perforation after gastro-oesophagal surgery. The study reported complete healing of the leak/perforation, without the need for further treatments suggesting E-VAC therapy as a safe option for leak management.
Radical Cystectomy compared to intravesical BCG immunotherapy for high-risk Non-Muscle Invasive Bladder Cancer – is there a long-term survival difference?
Depression is a severe mood disorder that affects individuals of all ages and is associated with significant morbidity and mortality. Worldwide, 17% of people are likely to experience depression and it is especially prevalent in patients with cardiovascular disorders. Escitalopram is commonly used in depression with comorbid hypertension as it decreases heart rate, improve sleep quality, and decrease blood pressure.
Diabetes mellitus and depression are major public health issues and depression was associated with a 60% increase of type 2 diabetes while type 2 diabetes was associated with 15% risk of depression. Escitalopram is effective in terms of controlling symptoms of depression without any adverse impact on glycemic parameters when used in depression patients with diabetes mellitus.
Depression and anxiety are common comorbid condition, with 35-60% of patients with depression having an anxiety disorder. Escitalopram monotherapy and in combination with clonazepam has good antidepressant effects which significantly improves depressive symptoms and has good tolerability profile in managing depression patients with comorbid anxiety.
Depression and anxiety disorder commonly occur together, and they have high severity of illness and significantly impair work functioning and quality of life. Generally, escitalopram, desvenlafaxine, sertraline are commonly utilized to manage depression and anxiety. Escitalopram monotherapy and in combination with clonazepam significantly improves depressive symptoms and has good tolerability profile.
Lacosamide enhances the slow inactivation of voltage-gated sodium channels (VGSCs) resulting in the stabilization of hyperexcitable neuronal membranes. Add on lacosamide provides effective seizure control and is generally well tolerated when used as a first add on therapy across a broad age range of AEDs.
Lamotrigine has an important AED in treatment of epilepsy as it has broad efficacy, long term effectiveness, well tolerability, favourable pharmacokinetics properties and lack of cognitive impairment. It can be an ideal AED in pregnant women because of its minimal effect on fetus and minimal fetal malformations compared to other AEDs.
Epilepsy is a group of disorder characterized by two or more unprovoked seizures. Levetiracetam is a newer AED with wide safety margin and minimal interactions with other antiepileptics. Also, it increases the rates of seizure freedom and is generally well tolerated compared to traditional AEDs.
Bipolar disorder is a chronic mental disorder with repetitive cycles of mania and depressive episodes. Lamotrigine is an effective option for the management of bipolar disorder, most significantly for its role in the prophylaxis of mood episodes and it is relatively safe and effective option for maintenance treatment in women.
AEDs are the mainstay of the treatment of epilepsy. Review diagnosis if seizure is not controlled and evaluate patients every 3 months. Lamotrigine is effective option in women with epilepsy. It is recommended to initiate monotherapy at low dose to evaluate drug interaction and side effect profile.
Major depressive disorder is severe mood disorder associated with significant morbidity and mortality. Escitalopram as an antidepressant has good efficacy which significantly improves the depressive symptoms with minimal drug interaction with better tolerability profile.
Escitalopram leads to a significant improvement of overall quality of life as well as overall pleasure and satisfaction with life which makes them very effective in the treatment of depression. It also provide better efficacy and safety compared to other antidepressants.
Antiepileptic drugs are the mainstay treatment of epilepsy. Levetiracetam is a novel AED with wide safety profile with minimal drug interactions. Also, has significantly higher retention rate and better seizure control compared to traditional AED.
Depression is a severe mood disorder with a lifetime prevalence of 16.5% in the adult population. Treatment with escitalopram results in a significant improvement of quality of life, improved sleep, enjoyment and satisfaction in patients with MDD which makes it very effective option for the treatment of depression.
Bipolar disorder is a chronic mental disorder with repetitive cycles of mania/hypomania as well as depressive episodes, resulting in marked impairment in overall functioning and quality of life. Psychotherapy is an important aspect of bipolar management. Lamotrigine is an important pharmacologic option for the management of bipolar disorder as it is relatively safe and effective option for maintenance treatment.
Epilepsy is third most common neurological disorder characterized by two or more unprovoked seizures. Levetiracetam is a newer AED with wide safety profile with minimal drug interactions. Also, has significantly higher retention rate and better seizure control compared to traditional AED.
Bipolar disorder is a common psychiatric disorder with repetitive cycles of mania and depressive episodes. Lamotrigine is an effective option for the management of bipolar disorder, most significantly for its role in the prophylaxis of mood episodes and it is relatively safe and effective option for maintenance treatment.
Lamotrigine is an anticonvulsant which is an effective mood stabilizer commonly used for the management of bipolar disorder. It plays and important role in the prophylaxis of mood episodes and it is relatively safe and effective option for maintenance treatment in women with bipolar disorder in the reproductive age group and also pregnant women.
Major depressive disorder is severe mood disorder associated with significant morbidity and mortality. Escitalopram as an antidepressant has good efficacy which significantly improves the depressive symptoms. It has minimal drug interaction and better tolerability profile compared to other antidepressants.
Depression and anxiety are common comorbid condition, with 35-60% of patients with depression having an anxiety disorder. Escitalopram monotherapy and in combination with clonazepam has good antidepressant effects which significantly improves depressive symptoms and has good tolerability profile in managing depression patients with comorbid anxiety.
Epilepsy is a group of disorder characterized by two or more unprovoked seizures. Levetiracetam is a novel AED with wide safety margin and minimal interactions with other antiepileptics. Another AED lacosamide as an add on provides effective seizure control and is generally well tolerated when used as a first add on therapy across a broad age range of AED.
Lacosamide is approved as add on therapy in partial onset seizure. It block sodium channels, enhancing slow inactivation of neuronal membrane. It significantly reduces seizure frequency with high rate of longterm seizure freedom. Also, has minimal drug interaction and safer to use.
Epilepsy is a common neurological condition affecting 1-2% of population. Lacosamide is a newer AED which enhances the slow inactivation of voltage-gated sodium channels resulting in the stabilization of hyperexcitable neuronal membranes. Add on lacosamide provides effective seizure control and is generally well tolerated when used as a first add on therapy across a broad age range of AEDs.
Rapid up-titration of lacosamide seems to be a feasible option in appropriate clinical conditions and may be particularly beneficial for epilepsy patients at high risk of short-term seizure recurrence.
Partial-gland high-intensity focused ultrasound (HIFU) was safer than whole-gland HIFU, and they had similar oncological outcomes. More prospective randomized controlled trials are warranted to assess the benefits of HIFU for the treatment of prostate cancer.
Diagnosing and categorization of epilepsy type is important for management of epilepsy. The commonly used epilepsy drugs in different types of epilepsy are phenobarbitone which effective in partial seizure; levetiracetam, Briveracetam, clobazam are also commonly used for the management of partial and generalized seizure.
Depression is severe mood disorder characterized by low mood, weight changes, insomnia or hypersomnia. Depression and anxiety are common comorbid condition, with 35-60% of patients with depression having an anxiety disorder. Escitalopram monotherapy and in combination with clonazepam has good antidepressant effects which significantly improves depressive symptoms and has good tolerability profile.
Stroke is the second leading cause of death worldwide. In case of haemorrhagic stroke, urgent craniotomy, evacuation of hematoma and decompression is recommended. Mechanical thrombectomy and IV thrombolysis is recommended in patients with ischemic stroke.
Epilepsy is a group of disorder characterized by two or more unprovoked seizures. Lacosamide enhances the slow inactivation of voltage-gated sodium channels resulting in the stabilization of hyperexcitable neuronal membranes. Add on lacosamide provides effective seizure control and is generally well tolerated when used as a first add on therapy across a broad age range of AEDs.
Stroke is the second leading cause of death worldwide. Immediate airway, breathing and circulation is required in patients with stroke. In case of haemorrhagic stroke, craniotomy, evacuation of hematoma and decompression is recommended. Mechanical thrombectomy and IV thrombolysis is recommended in patients with ischemic stroke.
Bipolar disorder is a chronic mental disorder with repetitive cycles of mania/hypomania as well as depressive episodes. Lamotrigine is an effective option for the management of bipolar disorder, most significantly for its role in the prophylaxis of mood episodes and it is relatively safe and effective option for maintenance treatment in women.
Assessment of head injury can be done by Glasgow comma scale which evaluates the severity of head injury. During head injury management, airway and circulation are managed immediately to avoid secondary injuries. If patient has large occlusion, ICH or hematoma, craniotomy is planned to remove the clot.
Lacosamide enhances the slow inactivation of voltage-gated sodium channels resulting in the stabilization of hyperexcitable neuronal membranes. Add on lacosamide provides effective seizure control and is generally well tolerated when used as a first add on therapy across a broad age range of AEDs.
Depression and anxiety disorder commonly occur together, and they have high severity of illness and significantly impair work functioning and quality of life. Generally, escitalopram, desvenlafaxine, sertraline are commonly utilized to manage depression and anxiety.
The preferred choice of drugs in neonatal seizure and infants are benzodiazepines such as midazolam, diazepam, lorazepam. The drugs used in infantile spasm are carbamazepine, oxcarbazepine and levetiracetam as they have less drug interaction with other drugs and effective in broad spectrum of different epilepsy types.
Major depressive disorder is severe mood disorder associated with significant morbidity and mortality. The commonly used SSRI for depression management is Escitalopram. As an antidepressant it has good efficacy which significantly improves the depressive symptoms with minimal drug interaction and better tolerability profile.
Epilepsy is a group of disorder characterized by two or more unprovoked seizures. Lamotrigine is an important AED in treatment of women with epilepsy as it has broad efficacy, long term effectiveness, well tolerable and favourable pharmacokinetics properties. It is commonly used AED in pregnant women because of its minimal effect on fetus and minimal fetal malformations compared to other AEDs.
Levetiracetam is a newer AED with wide safety profile with minimal drug interactions and has significantly higher retention rate and better seizure control compared to traditional AED. Add on lacosamide provides effective seizure control and is generally well tolerated when used as a first add on therapy across a broad age range of AEDs. Lamotrigine is commonly used in WWE because of minimal foetal malformation.
Antiepileptic drugs are the mainstay treatment of epilepsy. Lacosamide enhances the slow inactivation of voltage-gated sodium channels (VGSCs) resulting in the stabilization of hyperexcitable neuronal membranes. Add on lacosamide provides effective seizure control and is generally well tolerated when used as a first add on therapy across a broad age range of AEDs.
Choice of an AED for the treatment of epilepsy in infants and children depends not only on the efficacy of the agent but also in safety, impact on behavior and learning, and existing patient co-morbidities. LEV has become an attractive choice in children because of its lack of hepatic metabolism, minimal drug interactions, activity against several seizure types.
Major depressive disorder is severe mood disorder associated with significant morbidity and mortality. Escitalopram as an antidepressant has good efficacy which significantly improves the depressive symptoms with minimal drug interaction and has better tolerability profile.
Epilepsy is a group of disorder characterized by two or more unprovoked seizures. Lamotrigine is an important AED in treatment of epilepsy as it has broad efficacy, long term effectiveness, well tolerable and favourable pharmacokinetics properties. It is commonly used AED in pregnant women because of its minimal effect on fetus and minimal fetal malformations compared to other AEDs.
This is a randomised, double-blind, multicentre, phase 3 trial evaluating 144-week efficacy and safety of fixed-dose combination bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir-containing regimens for initial treatment of HIV-1 infection. The findings showed that bictegravir, emtricitabine, and tenofovir alafenamide continued to be non-inferior to dolutegravir-containing regimens at week 144.
This study demonstrated reduction in the miscarriage rates after DHEA supplementation in women with diminished ovarian reserves (DOR). Miscarriage rates after DHEA supplementation not only were lower than in an average national IVF population but were comparable to rates reported in normally fertile populations. Low miscarriage rates, comparable to those of normal fertile women, are indicative of the possible beneficial effect of DHEA on embryo ploidy.
Treatment with nintedanib resulted in a slower rate of progression of interstitial lung disease and a significantly lower annual rate of decline in forced vital capacity, irrespective of the fibrotic pattern in high resolution computed tomography scan as compared to placebo. Diarrhea was a common adverse event reported by the patients receiving nintedanib.
Epilepsy is a group of disorder characterized by two or more unprovoked seizures. Epilepsy management depends on type of seizure and individual patients. Lacosamide is effective in patient with partial epilepsy. Levetiracetam and lamotrigine is effective in women with epilepsy in childbearing age bcz of minimal drug interaction and better tolerability profile.
Besides diagnosis and treatment, in LUTS/BPO, comprehensive assessment of patient’s illness, preference & expectations needs equal attention. Such patient centric approach may further improve drug adherence and some unmet needs in this area, potentially reducing complications and cost.
Depression and anxiety are common comorbid condition, with 35-60% of patients with depression having an anxiety disorder. Escitalopram monotherapy and in combination with clonazepam has good antidepressant effects which significantly improves depressive symptoms and has good tolerability in managing depression patients with comorbid anxiety
Major depressive disorder is severe mood disorder associated with significant morbidity and mortality. Escitalopram as an antidepressant has good efficacy which significantly improves the depressive symptoms with minimal drug interaction with better tolerability profile.
Epilepsy is a chronic neurological condition which affects over one million women of childbearing age. Lamotrigine and levetiracetam are effective in childbearing age and pregnant women because of its minimal effect on foetus and less drug interaction with oral contraceptive. Also, both drugs are safe and better tolerability profile
Diabetes mellitus (DM) and depression are major public health issues. Depression could facilitate the onset of diabetes through disturbances in eating behaviours and drug induced weight gain. Escitalopram is effective in terms of controlling symptoms of depression without any adverse impact on glycemic parameters when used in depression patients with diabetes mellitus.
Escitalopram as an antidepressant is associated with high therapy continuity, high efficacy, adherence due to high tolerability and reduced risk of relapse. It is an effective first line option in the management of patients with MDD.
Choice of an AED for the treatment of epilepsy in infants and children depends not only on the efficacy of the agent but also in safety, impact on behavior and learning, and existing co-morbidities. Levetiracetam is effective in children with epilepsy because of minimal drug interactions, activity against several seizure types and with possible no evident side effect
Epilepsy is a group of disorder characterized by two or more unprovoked seizures. levetiracetam is a novel AED with wide safety margin without any requirement for serum drug monitoring, and minimal drug interactions with other antiepileptics. It significantly increases the rates of seizure freedom and well tolerated without major adverse effects
Bipolar disorder is a chronic mental disorder with repetitive cycles of mania/hypomania as well as depressive episodes. Lamotrigine is an important pharmacologic option for the management of bipolar disorder, most significantly for its role in the prophylaxis of mood episodes, also it is relatively safe and effective option for management of BD
Management of epilepsy in adults depends on various factors including comorbidity, type of seizure and concomitant medication. Levetiracetam is effective in diverse epilepsies, and the evidence shows that it increases the rates of seizure freedom and well tolerated without major adverse effects. Also, it has an advantage in pregnant women as it decreases risk of congenital malformation.
The patient with head injury is classified as mild moderate and severe head injury by Glasgow comma scale. During head injury management, airway and circulation are managed immediately to avoid secondary injuries. If patient has large occlusion, ICH or hematoma, craniotomy is planned to remove the clot.
Rare lung diseases are rare but integral part of for pulmonary medicine. Many young clinicians need guidance on how to differentiate and treat various Rare Lung Diseases. Also, there are new updates on Chronic Hypersensitivity Pneumonitis. This PURVIEW is an opportunity as it entails discussions on broad spectrum of Rare Lung Diseases and their management.
Children with epilepsy have higher rates of learning difficulties. Hence, the treatment should be individualized for children with epilepsy. Selection of AEDs depends on patients, type of seizure, drug interaction and comorbidity. Levetiracetam, clobazam, topiramate are the common AEDs preferred in children.
Dementia is major cause of disability in late life. The prevalence of dementia is 6-8% in patient above 65 years of age and 30% or more in patient aged 80 years and above. Donepezil and Rivastigmine are the commonly used drug to treat dementia with minimal drug interaction and better tolerability profile than other drugs
OCD is disease with obsession and compulsion in which patients has doubts, suspicions and repetitive actions. Psychotherapy and CBT is important aspect of managing OCD. SSRI are commonly used medication to supress the symptoms of OCD.
Lamotrigine is effective in patients with bipolar disorder with superior efficacy, better tolerability and is safer to use. It is more effective in depressive phase compared to maniac phase and usually recommended for maintenance treatment of bipolar disorder.
This large-scale Indian study demonstrated a high risk of acute respiratory infection due to indoor pollution in children aged below 5 years. Policies that would cut down the exposure to indoor air pollution are warranted.
Dr Uday Jadhav talks about the case of a patient with myocardial infarction and dyspnoea.
Dr Uday Jadhav talks about the case of hypertensive patient diagnosed as HFpEF.
Dr Uday Jadhav talks about chronic HFrEF and acute decompensation.
Dr Uday Jadhav talks about the role of cardiac fibrosis markers in heart failure.
Results of the SENSCIS trial demonstrated that nintedanib had a lower annual rate of decline in forced vital capacity among patients with interstitial lung disease (ILD) associated with systemic sclerosis as compared to placebo. There was no other clinical benefit observed for other manifestations of systemic sclerosis. Nintedanib treatment had a safety profile similar to that observed in patients with idiopathic pulmonary fibrosis, with diarrhea being the most common adverse event.
In a real-world clinical setting, the fixed dose combination of oral cefixime (400 mg) and moxifloxacin (400 mg) was effective in improving all symptoms in patients with lower respiratory tract infections without causing any adverse event.
Varicocele repair increased the pregnancy and live birth rates irrespective of the semen analysis result. Varicocele treated azoospermic men had higher sperm retrieval success rate. Varicocele repair might benefit infertile men prior to joining a fertility program.
The present study is the pooled analysis of two phase III studies, ATLAS and FLAIR, that compared efficacy and safety of monthly intramuscular (IM) injections of long-acting (LA) cabotegravir (CAB) + LA rilpivirine (RPV) to the oral current antiretroviral regimen (CAR). The study showed that monthly IM injections of CAB + RPV LA are noninferior to CAR in maintaining HIV-1 virologic suppression in treatment-experienced participants.
Epilepsy management depends on efficacy, safety and pharmacokinetic profile of AED, seizure type and patient characteristics. It is recommended to start monotherapy, if there’s in adequate response to the monotherapy the add on drug can be included in management. Lamotrigine, levetiracetam, lacosamide are commonly used drug in focal epilepsy
Migraine is headache disorder which is more common in female occurring at younger age. The first line drugs for chronic migraine includes sodium valproate, propranolol. In case of acute migraine, the first line medication includes ibuprofen, aspirin and triptans including rizatriptan and zolmitriptan.
According to the findings of this Saudi Arabian study, lacosamide was effective and well-tolerated in patients with focal epilepsy.
Depression is a mental disorder associated with persistent low mood. Depression and anxiety disorder commonly occur together, with high severity of illness which significantly impair work functioning and quality of life. SSRI and psychotherapy is the recommended choice of therapy for treating depression and comorbid condition.
AEDs are the mainstay for epilepsy management. Compared to conventional AEDs, newer AEDs are better tolerated and safer to use in epilepsy patients. Amongst newer AEDs, levetiracetam is the novel drug with wide safety margin, does not require serum drug monitoring and has no/minimal drug interaction with other AEDs.
In epilepsy, despite the availability of many antiepileptic drugs (AEDs) more than 30% of patients continue to experience seizures and have drug-resistant epilepsy which can be eased by Precision medicine (PM) which is tailoring of medical treatment to the individual characteristics of each patient. In epilepsy, the precision medicine can be used for medical treatments that target specifically the mechanisms responsible for the manifestations of the disease in individual patients to reduce seizures.
Schizophrenia is disorder of thought, perception and behaviour with or without cognitive functioning. The 2nd generation antipsychotics such as olanzapine, risperidone, Amisulpride are commonly used drug as they reduce both negative and positive symptoms of schizophrenia with better tolerability profile. Schizophrenia patient with aggression and suicidal tendency usually requires hospitalization.
According to NICE guidelines, the choice of antidepressants should be based on side effect profile, patient preference and previous patient exposure. SSRI are commonly used as first line for treatment of depression in adults and children. Amongst them, escitalopram is commonly preferred SSRI because of better efficacy and safety profile.
Lacosamide enhances the slow inactivation of voltage-gated sodium channel and it is available as tablet and injection formation. Initially, the administration is started as 50 mg/day. As an AED it provides effective seizure control and is generally well tolerated when used as a first add on therapy across a broad age group.
Epilepsy majorly consist of 2 types: generalized and focal. The aim of management is to reduce the seizure frequency and preventing seizure. Oxcarbazepine, lamotrigine, levetiracetam are commonly used first line antiepileptic drugs. Recently approved lacosamide is the most commonly used add on AED for epilepsy management.
Migraine is most common headache disorder which is diagnosed with certain clinical criteria including unilateral or bilateral headache which last from 4 -72 hours and pain is usually pulsated. Most common differential diagnosis is tension type headache, secondary headache, trigeminal autonomic cephalgia which needs to be diagnosed for the correct management.
Recognizing the widening “treatment gap,” the ASBMR developed a consensus of a broad multi-stakeholder coalition regarding several aspects of Osteoporosis treatment.
Few facts about common myths related to hair.
A LIVE symposium on ‘Breath of Fresh Air in OAD’, with a focus on the importance of preventing exacerbations in OAD management. This symposium aims to provide clinical perspectives on understanding pathogenesis of OAD exacerbations, highlighting the various triggers, patient factors and their interactions leading to exacerbations and discuss various preventive measures available with newer therapies and drug delivery systems to reduce the burden and impact of exacerbations on the patient.
Depression is a mood disorder characterised by persistent low mood. Mild depression can be treated by psychotherapy; however, moderate and severe episodes of depression require pharmacotherapy. SSRIs are recommended as first line treatment in managing depression and the response can be evaluated at intervals before up titrating the dose.
The dilemma of selection of right antipsychotic in the real world revolves around a medication that shows efficacy, tolerability and is safer to use. It is recommended to initiate treatment with monotherapy and up titrate the dose before initiating polytherapy. Olanzapine and respiredone are the first choice in overweight patient.
OCD is a disease with obsession and compulsion in which patients has doubts, suspicions and repetitive actions. Psychotherapy and CBT are important for managing OCD. SSRI are recommended as the first line medication to supress the symptoms of OCD.
Migraine treatment should be initiated as soon as the migraine attack starts. CGRP antagonist, CGRP monoclonal antibodies are the new emergent therapies in migraine. CGRP antagonist including erenumab injection is found to be effective in migraine management with no major side effects.
Sacubitril/valsartan exhibited generally consistent efficacy and safety across various dose levels in hemodynamically stabilized patients with ADHF. Sacubitril/valsartan should therefore be broadly initiated in-hospital and continued post-hospitalization even in patients who may not tolerate early up-titration to the target dose.
The doctor talks about errors in ART labs and how setting these key performance indicators can be beneficial to check performance and to maintain standard, assure quality and benchmark against established standards.
According to this first-of-its kind study conducted in pediatric population, loading dose of colistin improved the overall efficacy without any adverse impact on the renal function (vs. no loading dose) in critically ill children affected with severe nosocomial infections.
In this webinar, the doctor briefs about effectiveness of a dynamic quantification tool - the HDP GESTOSIS score - to screen hypertensive disorders of pregnancy.
The present study evaluated Saccharomyces boulardii (SB) as a possible therapeutic intervention in acute rotavirus diarrhoea in Indian children. The study showed that SB 250 mg orally twice a day for 5 days given during an acute episode of rotavirus diarrhoea in children aged under five resulted in significant shortening in the diarrheal duration and duration of hospitalization without any adverse events.
The present study compared the efficacy and safety of intravenous levofloxacin (LVFX) at 750 mg per day for 5 days with an intravenous/oral regimen of LVFX at 500 mg per day for 7–14 days in the treatment of patients with complicated urinary tract infection and acute pyelonephritis. The study showed that two therapies had similar clinical efficacy, microbiological efficacy, and tolerance.
This large-scale study demonstrated very low rate of loop diuretic (LD) dose down-titration in chronic HF patients, depicting the high discordance between ‘real-world’ HF practice patterns and guidelines. Clinicians should attempt LD dose down-titration in stable euvolemic patients.
In her talk, the doctor gives brief on the nuances of ICSI, including sperm morphology and motility, and indications of and advances in IMSI.
Lacosamide appeared to improve depression and anxiety symptoms in patients with focal refractory epilepsy. This effect was independent of the seizure control effect of lacosamide.
Treatment with letrozole was associated with high resolution rate and better safety profile as compared with a chemotherapeutic agent such as methotrexate in the medical treatment of ectopic pregnancy.
rFSH prefilled syringe was safe, effective and non-inferior to rFSH pen for ovarian stimulation in infertile women undergoing in-vitro fertilization-embryo transfer.
The results of this first North American and European study showed no unexpected safety concerns and a similar safety profile of mirabegron add-on therapy to that expected for the individual monotherapies in men with overactive bladder symptoms associated with benign prostatic hyperplasia receiving tamsulosin.
The efficacy and safety of once-daily (OD) dosing of mesalazine was comparable to twice-daily (BD) dosing in patients with ulcerative colitis. Since ulcerative colitis requires long-term treatment, OD dosing regime can be more convenient than BD dosing regime.
In the first session, doctor elaborates on how placenta accreta is emerging as one of the biggest obstetric Challenge and how it can be managed optimally. In the panel discussion, the moderator takes us through various case scenarios of effectively managing bleeding in late pregnancy, such as, due to abruptio placentae, placenta previa, vasa previa and rupture uterus.
Treatment with omalizumab resulted in significant improvements in endoscopic, clinical, and patient-reported outcomes in severe chronic rhinosinusitis with nasal polyps (CRSwNP) with inadequate response to intranasal corticosteroids. Omalizumab was safe and well tolerated in all the patients.
In his talk, the doctor elaborates on impact of air quality of ART lab in the IVF outcomes, volatile organic compounds and their management, as well as latest developments.
The present study compared lapatinib plus capecitabine with capecitabine alone in women with progressive, HER2-positive, locally advanced or metastatic breast cancer. The study showed that lapatinib plus capecitabine was superior to capecitabine alone in women with HER2-positive advanced breast.
Rivaroxaban is a potent, selective, orally active direct inhibitor of the activated serine protease Factor X (FXa), which plays a central role in the blood coagulation. It has good bioavailability (80%), is highly protein-bound, and has few drug interactions.
Nintedanib 150 mg twice a day demonstrated acceptable safety profile and was associated with reduction in the decline in lung function, with fewer acute exacerbations and preserved quality of life in patients with idiopathic pulmonary fibrosis.
This webcast provides the detailed place in therapy of Liposomal Amphotericin B for the management of invasive fungal infections (IFIs) in hematological patients who are at the highest risk to get infected with IFIs.
In this webinar, the doctor talks about history of IVF, where do we stand in terms of PGT and current trends in PGT.
Administration of meropenem by continuous infusion improves drug exposure in plasma and epithelial lining fluid (ELF) in critically ill patients with nosocomial pneumonia. The highest licensed dose of 6 g/day (2 g/8 h) seemed to be necessary to achieve an optimal coverage in ELF for all susceptible isolates (MIC ≤ 2 mg/L) in patients with conserved renal function. An alternative therapy should be considered in the treatment of nosocomial pneumonia caused by gram-negative bacteria with a MIC greater than 2 mg/L.
This is one of the first studies that clinically validated MII-pH testing and ascertained its ability in guiding clinical management in children with suspected GERD. Treatment decisions guided by MII-pH testing were associated with improved symptom and QOL in children.
The doctor gives perspectives whether preimplantation genetic testing (PGT) is meant for all patients undergoing IVF, starting with its advantages and disadvantages and what does evidence say about PGT in IVF.
The study demonstrated that a fixed-dose combination of gatifloxacin/prednisolone eye drops was as effective as the non-fixed combination of individual agents for preventing infection and inflammation in patients undergoing phacoemulsification and IOL implantation.
This trial compared the combination of letrozole plus lapatinib with letrozole plus placebo as first-line treatment of patients with HR-positive MBC, including a population with known HER2- positive tumours. Results showed that letrozole-lapatinib combination was well tolerated and produced a clinically meaningful improvement in several efficacy endpoints.
Epilepsy occurs due to abnormal firing of neuron. In elderly it is associated with significant morbidity and mortality. Treatment in elderly is challenging as they are on multiple drugs. Hence the monotherapy AED treatment is recommended at low dose with drug having minimal drug interactions such as levetiracetam, brivaracetam.
Lacosamide is a newer antiepileptic drug (AED) approved for as an adjunct for partial seizure which modulates sodium voltage gated channel. It reduces seizure frequency when given with another AED at dose of 400-600 mg a day. It is also well tolerated drug and has comparable efficacy with conventional AEDS.
Epilepsy is the most common neurological disorder and the most common cause in elderly patients includes stroke related seizure, dementia and trauma. The preferred drugs for managing elderly patients with epilepsy includes levetiracetam and lamotrigine as they are well tolerated and have less drug interactions. AEDs which also acts as depressants should be avoided in elderly patient.
Pre-treatment with mifepristone followed by misoprostol was more effective than misoprostol alone in the management of missed miscarriage. Mifepristone and misoprostol combination treatment increased the chance of successful miscarriage and reduced the need for surgical intervention.
In this panel discussion, the moderator and panelists try to bust myths and misconceptions associated with contraception, thereby ensuring optimal usage and protection against unwanted pregnancy.
In this talk, the doctor briefs on how contraception can pose a challenge in women with medical disorders and elaborates the WHO medical eligibility criteria for contraceptive use.
The doctor highlights various aspects of Indian penal code, MTP act and POCSO act in association with safe abortion.
The doctor elaborates on how the pandemic gave rise to challenges in accessing contraception, opportunities and solutions in obtaining the same.
In this talk, the doctor elaborates on how a practicing gynaecologist can ensure safe abortion with the help of components laid in comprehensive abortion care guidelines.
The doctor highlights the huge unmet need for modern contraceptives in India; existing and newer contraceptive options along with their advantages and disadvantages.
Treatment for 8 weeks with fluticasone was as effective as mometasone in patients with moderate-to-severe allergic rhinitis and resulted in a significant improvement in the total nasal symptom score, with no significant difference between the two.
The present study evaluated whether administration of azithromycin during an acute bronchiolitis (AB) event reduces subsequent wheezing and hospital readmissions. The 6 months follow-up results indicated that azithromycin at the time of admission for AB showed relevant protection for recurrence of wheezing 3 months after hospitalisation for AB.
The doctor talks about current fertility preservation techniques and options for both, males and females, and what is the future of this procedure.
This study highlights that colistin is erroneously blamed for nephrotoxicity and nephrotoxicity rates may be over-estimated as AKI is common in sepsis and independent of drugs used to treat sepsis. There is no statistical difference in nephrotoxicity observed in patients receiving colistin compared to those receiving βL- βLIs or carbapenem.
Lacosamide exhibited no adverse impact on the lipid profile in patients with newly diagnosed epilepsy.
Nintedanib reduced the decline in forced vital capacity (FVC), which is consistent with a slowing of disease progression in patients with idiopathic pulmonary fibrosis (IPF). The most frequent adverse event reported by the nintedanib groups was diarrhea, which led to discontinuation of the study drug in less than 5% of patients.
The present study is the pooled analysis of studies LEAP 1 and LEAP 2 that compared efficacy and safety of lefamulin with moxifloxacin for treatment of community-acquired bacterial pneumonia. The analysis showed that lefamulin achieved a similar clinical response as moxifloxacin.
The present study compared the outcomes of endoscopic and surgical drainage in patients with chronic pancreatitis. The 2-year follow-up results suggested that surgical drainage was more effective than endoscopic treatment.
A simple, low-cost quality intervention bundle can significantly increase appropriate antimicrobial prescribing and appropriate investigations and reduce the duration of the total antibiotics.
In this panel discussion, the moderators and panelists shed light on important factors that can affect the pregnancy rates in IVF.
Uncut Roux-en-Y gastrojejunostomy after distal gastrectomy is still the essential treatment for gastric cancer. The present study evaluated the safety and feasibility of enhanced recovery after surgery (ERAS) for total laparoscopic uncut Roux-en-Y gastrojejunostomy after distal gastrectomy. Findings showed that perioperative administration of the ERAS concept showed obvious advantages when intraoperative parameters, postoperative clinical indicators, and postoperative stress responses were analysed.
This sub-group analysis of the PARADIGM HF study demonstrates under-usage of ICD in patients with HFrEF despite reduction in sudden cardiac death. Sacubitril/valsartan reduced the risk of SCD in this patient subgroup regardless of the use of ICD.
Epilepsy is a group of disorder characterized by two or more unprovoked seizures. The speaker mentioned that Levetiracetam as an AED has wide safety margin and minimal drug interactions with other antiepileptics. Also, it increases the rates of seizure freedom and is generally well tolerated.
Major depressive disorder is a severe mood disorder associated with significant morbidity and mortality. Escitalopram as an antidepressant has good efficacy which significantly improves the depressive symptoms with minimal drug interaction and improved QoL.
Epilepsy is the third most common neurological disorder. The most common cause in elderly includes stroke related seizure followed by dementia & trauma. The management in elderly requires adequate evaluation of pharmacokinetic properties of AED & non-AEDs for the correct dosing regimen to reduce the side effects of AEDs and better efficacy.
The global burden of disease has found both depression and panic to rank very high in terms of its disabling impact on individual. SSRI are preferred drug because of simplicity of use and generally safer and tolerable profile which enhance compliance in the patients.
Epilepsy in elderly poses both diagnostic and therapeutic challenges to the individual. Some important differentials to be considered in elderly includes syncope, stroke, metabolic disturbances. Treatment is challenging because of associated comorbidity and drug interactions which needs to be considered during treatment.
This sub-study of the DREAMS study demonstrates that increasing severity of dry eye disease leads to decreased work productivity and activity level and has a negative economic impact.
This real-world study conducted in Taiwan, demonstrated lacosamide to be effective and safe in patients with focal impaired awareness seizures and/or secondarily generalized seizures
According to sub analysis of VERIFY trial early aggressive combination with vildagliptin and metformin provides greater and durable glycaemic control in YOD patients (who face a very long duration of disease) compared to metformin alone.
This subgroup analysis of the PIONEER-HF trial demonstrated sacubitril/valsartan to be equally effective and safe in African-American and non-African-American patients with acute decompensate heart failure.
Many common factors increase or decrease absorption of iron. Knowing these factors may help avoid mistakes one makes while taking iron supplements, and thereby help improve the haemoglobin concentration.
Amongst children with acute diarrhoea, low dose zinc (10 mg and 5 mg per day) was non-inferior to high dose zinc (20 mg/day) in terms of duration of diarrhoea and mean number of stools. The use of lower doses was associated with lower risk of vomiting.
According to WHO, headache accounts for top 10 disability worldwide. CGRP antagonist, CGRP monoclonal antibodies and 5HT 1F receptors are the new emergent therapies in migraine. Botox is an additional option for severe treatment of migraine.
As per the results of this diagnostic study, the new urine-based DNA mutation detecting test is a promising alternative for the detection of recurrence in patients with non-muscle-invasive bladder cancer.
This is a prospective, randomized study evaluating the effect of preoperative administration of paracetamol (PARA), ibuprofen (IBUP), or aceclofenac (ACEC) on the success of maxillary infiltration anaesthesia in patients with irreversible pulpitis. The study showed significant improvement in the efficacy of maxillary infiltration anaesthesia with preoperative administration of PARA, IBUP, and ACEC in patients with irreversible pulpitis
Ibuprofen (400 mg) and aceclofenac (100 mg) were found to be effective in controlling postoperative swelling, pain and trismus after surgical removal of impacted lower-third molars. Alleviation of pain and trismus was found to be better with ibuprofen as compared to aceclofenac. Both the drugs had comparable efficacy with respect to control of facial swelling.
Emzumab is omalizumab 150mg powder for subcutaneous injection. This Emzumab monograph captures efficacy studies, safety data, how to reconstitute Emzumab, dose calculators and much more.
This study identifies various risk factors associated with progression of visual field in primary open angle glaucoma patients. The study further demonstrates that adding dorzolamide rather than brinzolamide to timolol significantly reduced the risk of progression.
Tamsulosin and Solifenacin combination improves Prostate & OAB symptom scores and QOL scores as compared to Tamsulosin alone.
Silodosin, a selective α1A-adrenoceptor antagonist, is a safe option that yields relief and improves health-related QoL in patients suffering from nocturia in BPH.
Amongst patients undergoing surgical extraction of the third molar, intramuscular ketorolac had a better pre-emptive analgesic effect over diclofenac sodium. Immediate post-operative pain free period did not differ significantly between the two groups.
The present study compared the efficacy of Saccharomyces boulardii and lactic acid-producing probiotics in acute paediatric diarrhoea. The study data suggest that Saccharomyces boulardii is more effective than lactic acid-producing probiotics in children six months to 5 years of age.
Compassionate use of remdesivir in pregnant and postpartum women hospitalized with severe Covid-19 was associated with high clinical recovery rates and was safe and well tolerated.
Triple therapy with the once-daily combination of TFC (tiotropium/formoterol/ciclesonide) resulted in improvements in pulmonary function and health status in patients with chronic obstructive pulmonary disease (COPD). The effects were more pronounced in non-smokers as compared with smokers, suggesting that non-smokers with COPD might benefit from added treatment with inhaled corticosteroid.
The ADVANCE trial compared the efficacy and safety of a triple-therapy combination of emtricitabine and dolutegravir plus either of two tenofovir prodrugs - tenofovir alafenamide fumarate or tenofovir disoproxil fumarate against the tenofovir disoproxil fumarate, emtricitabine and efavirenz. The results of this study confirmed the 48-week efficacy and safety data.
Amongst patients with T2DM and CKD, canagliflozin treatment was associated with early, sustained reductions in albuminuria that were independently associated with lower incidence long-term kidney and CV outcomes. Monitoring albuminuria during canagliflozin treatment is important to track kidney and CV prognosis.
This is the long-term extension study that evaluated efficacy and safety of tocilizumab monotherapy in patients who were part of the AMBITION study. The 5-year results confirm the continued efficacy and safety of TCZ as monotherapy in patients with active rheumatoid arthritis.
This is the first study to measure the effects of physical activity interventions that begin before bariatric surgery and continue postoperatively. The study compared two levels of interventions with bariatric surgery alone in promoting physical activity and structured, bout-related exercise. The study showed that patients in exercise counselling group had more steps and bout-minutes/week than standard care and pedometer group, demonstrating that combining self-monitoring, education, and a collaborative approach to exercise promotion can be effective.
The 3-year interim analysis of the ongoing POISE trial demonstrated long-term efficacy and safety of obeticholic acid in patients with primary biliary cholangitis who are intolerant or inadequately responsive to ursodeoxycholic acid. Treatment with obeticholic acid resulted in improvements in markers of cholestasis and liver enzymes.
In this keynote lecture, the doctor talks about evolution of infertility management and journey of IVF in India and the pioneering work of Dr. Subhas Mukherjee in the field of IVF.
It’s a case based discussion on different aspects of smile design principles. With the special mention on, why the smile design principles are important to know and what is the application of it in the field of dentistry.
Dr P K Hazra talks about the case of hypertensive patient with discomfort and fatigue diagnosed as HFpEF.
Dr P K Hazra talks about the importance of the time of initiation of MRA in HFrEF patients.
Dr P K Hazra talks about the use of MRA therapy across the HF continuum.
Dr P K Hazra talks about when to start different therapies in heart failure.
Dr P K Hazra talks about the evolution of different heart failure therapies.
This study determined the rates of intra-operative hyponatraemia development post use of hypotonic intravenous fluids in children undergoing minor elective surgical procedures. The study showed a comparable risk of developing hyponatremia in healthy children managed with hypotonic or parenteral maintenance solutions intraoperatively
Key highlights in Genitourinary cancer of the European Society of Medical Oncology (ESMO) 2020 Virtual Congress held from 19th to 21st September 2020.
Key highlights in Lung cancer of the European Society of Medical Oncology (ESMO) 2020 Virtual Congress held from 19th to 21st September 2020.
Amongst children with uncomplicated appendicitis, an initial non-operative strategy with antibiotics alone was successful in substantial proportion of patients compared with an urgent surgery approach. Patients treated with the former approach had fewer disability days at one year.
Treatment for 2 months with calcium orotate resulted in two-fold increase in the serum calcium levels, highly significant increased physical activity and symptomatic relief as compared to calcium carbonate + vitamin D3 in postmenopausal osteoporotic women. Treatment with calcium orotate was safe and well tolerated.
Treatment with remdesivir shortened the time to recovery in adults who were hospitalized with Covid-19 and had evidence of lower respiratory tract infection as compared to placebo.
Treatment with dupilumab was effective in reducing polyp size, sinus opacification, and symptom severity and was well tolerated in adults with chronic rhinosinusitis with nasal polyps (CRSwNP). Adding dupilumab to daily standard of care for patients with severe CRSwNP might be a good alternative.
DISCOVER Study is the first active-controlled, phase 3, non-inferiority trial comparing a new regimen for pre-exposure prophylaxis; emtricitabine and tenofovir alafenamide (F/TAF) with the current standard-of-care regimen, emtricitabine and tenofovir disoproxil fumarate (F/TDF). The study showed that F/TAF has non-inferior efficacy and has more favourable effects on bone mineral density and biomarkers of renal safety versus F/TDF when used as PrEP in HIV prevention.
The study explores the role of tear-film assessment using the lipid layer thickness (LLT) evaluation in patients with meibomian gland dysfunction (MGD) across various age groups. LLT evaluation is a valuable screening tool for MGD.
The current study demonstrated that oxcarbazepine had lower adverse drug reaction (ADR) profile as compared to carbamazepine and should be preferred over the latter as the first-line antiepileptic. The study also hints on using a lower than recommended dosage for both the medications considering the ADRs even at a low dosage.
The novel exhalation delivery system with fluticasone (EDS-FLU) resulted in significant improvements in all 4 diagnostically defining disease symptoms, polyp grade, and quality of life in patients with chronic rhinosinusitis with nasal polyps.
Artificial urinary sphincter implantation in women with stress urinary incontinence provided satisfactory long-term functional outcomes and is an effective treatment option after failure of first-line therapy.
Imbalance of antioxidant system correlates with the severity of age-related macular degeneration (AMD). Incorporating healthy lifestyle (healthy dietary habits supplemented with physical activity) may help restore the antioxidant balance and delay the progression of AMD.
This study provides a first head-to-head comparison on the long-term efficacy, safety and tolerability of three antiepileptic dugs in patients with newly diagnosed focal epilepsy.
Nebulized glycopyrrolate (GLY) 25 mcg BID and 50 mcg BID significantly reduced the risk of clinically important deterioration in patients with moderate-to-severe COPD. Treatment with GLY prevented clinically meaningful worsening in forced expiratory volume in 1 sec (FEV1) and patient-reported health status.
This is the first phase III trial on postoperative adjuvant chemotherapy in which the duration of oral 5-fluoropyrimidine drug for colorectal cancer was directly compared. The study showed that adjuvant chemotherapy with capecitabine for 12 months had substantial clinical impact compared to 6 month capecitabine.
This study compared the efficacy and safety of ciprofloxacin for 7 Days versus 14 Days in women with acute pyelonephritis. The findings showed that community-acquired acute pyelonephritis in women can be treated successfully and safely with oral ciprofloxacin for 7 days and even in older patients and those with a more severe infection.
This first-of-its-kind, large-scale, real-world study demonstrated that amongst T2DM patients, treatment with SGLT2i or GLP-1RA was associated with a lower risk of adverse kidney outcomes vs. DPP4i or SU.
According to this meta-analysis, sacubitril/valsartan, as compared with ACE inhibitors or ARBs, was associated with reduced risk of all-cause and CV mortality in patients with HFrEF and of HF hospitalization in patients with HFrEF and HFpEF.
Calcium orotate was associated with significantly higher oral bioavailability than calcium carbonate; Rapid, early and higher rate and extent of absorption compared to calcium carbonate; Substantially and significantly greater increases in serum calcium concentration, greater DAUC for serum calcium increment, and greater decreases in iPTH than equimolar amounts of calcium from supplements based on calcium carbonate.
This study is the first phase 3 randomised trial evaluating whether the mXELIRI regimen is non-inferior to the standard FOLFIRI regimen, with or without bevacizumab in both regimens, as second-line therapy for patients with metastatic colorectal cancer. The results showed that mXELIRI with or without bevacizumab is non-inferior and well tolerated to FOLFIRI with or without bevacizumab in terms of overall survival.
This tool helps in calculating colistin loading and maintenance doses for the patients as per the guidelines.
Treatment for 12 months with obeticholic acid, administered either with ursodiol or as monotherapy, in patients with primary biliary cholangitis resulted in significant decreases in alkaline phosphatase level, total bilirubin level, and other biochemical markers of disease. Obeticholic acid was associated with an increased incidence of pruritus, which was dose-dependent.
Combined administration of telmisartan/amlodipine 80/5 mg and rosuvastatin 20 mg significantly reduced blood pressure and improved lipid control in hypertensive patients with dyslipidemia. The combination may help achieve the therapeutic goal of higher compliance over the long term.
Major depressive disorder is a severe mood disorder associated with significant morbidity and mortality. Escitalopram as an antidepressant has good efficacy. It significantly improves the depressive symptoms with minimal drug interaction with better tolerability profile.
Migraine is a common neurological disorder occurring in different phases including prodrome, aura, headache and postdrome phase. Triptan is 5HT 1B/1D receptor agonist which causes cerebral vasoconstriction and reduces pain. It can be given by nasal, oral and subcutaneous route.
The gastrointestinal tolerability of ferrous ascorbate containing 16:84 iron:ascorbic acid ratio was better than the conventional formulations containing 13:87 or 20:80 ratio of iron and ascorbic acid respectively, resulting in 30% reduction in the gastrointestinal side effects and 50% reduction in epigastric burning sensation. The absorption of the test product was found to be better than the conventional formulations.
Young-onset diabetes or prediabetes increased CVD risks and all-cause mortality in long-term. This long-term risk for CVD incidence and all-cause mortality could be reduced with recovery of hyperglycaemia.
Ceftriaxone plus sulbactam plus EDTA significantly reduced the efflux pump expression and can be considered as an alternative in treating the E coli infections with efflux over expressed strains. EDTA disodium increases the susceptibility of E coil efflux over expressed strains by inhibiting efflux pumps
The intranasal spray containing azelastine hydrochloride (AZE) and fluticasone propionate (FP) offered significantly better, more rapid and more complete symptom control as compared to AZE monotherapy in Russian patients with moderate-to-severe seasonal allergic rhinitis or rhinoconjunctivitis.
Schizophrenia is a serious lifelong disorder affecting behaviour, thought and cognition Psychosocial rehabilitation is important for independent level of optimal functioning & better Quality of life. The key characteristics of successful rehabilitation depends on integrative care & active involvement of multiple caregivers.
Antiepileptic drugs are the mainstay treatment of epilepsy. Levetiracetam is a novel AED with wide safety profile with minimal drug interactions. Also, has significantly higher retention rate and better seizure control compared to traditional AED.
Depression and anxiety disorder commonly occur together, and they have high severity of illness and significantly impair work functioning and quality of life. Escitalopram, desvenlafaxine and sertraline are commonly utilized to manage depression and anxiety.
Empirical treatment with cefpodoxime resulted in high cure rates and clinical improvement in patients with acute maxillary sinusitis and acute tonsillopharyngitis. The favorable safety and tolerability profile seem to make cefpodoxime an empirical choice in adult Egyptian patients with acute upper respiratory tract infections.
Amoxicillin is the drug of choice in patients ‘at risk’ of developing bacteremia following dental extractions (BDE). Moxifloxacin seems a promising safe alternative for the prevention of BDE when beta-lactams are not indicated.
Key highlights in Breast cancer of the European Society of Medical Oncology (ESMO) 2020 Virtual Congress held from 19th to 21st September 2020.
The present study assessed whether the frequency of postoperative infectious and inflammatory complications in patients treated with placebo is greater than those treated with antibiotic after extraction of an impacted mandibular third molar. The study showed that postoperative treatment with amoxicillin/ clavulanic acid was efficacious in preventing complication.
Epilepsy is recurrent unprovoked seizure that requires accurate identification along with its type for the management and prognosis of patient. Lacosamide is widely used add on antiepileptic as it provides synergistic epilepsy control and controls the seizures.
Dr P P Mohanan talks about the case discussion on acute MI with fatigue and dyspnoea.
Dr P P Mohanan talks about the case of hypertensive patient with discomfort and fatigue diagnosed as HFpEF
Dr P P Mohanan talks about the case of chronic HFrEF patient now hospitalized for acute decompensation.
Dr P P Mohanan talks about the importance of MRAs in heart failure.
Treatment with ethinyl estradiol + cyproterone acetate had better clinical outcomes than metformin with respect to control of menstrual cycle regulation and hyperandrogenism. Metformin, on the other hand, showed beneficial effects on serum lipids; improving glucose tolerance; reducing body weight and improve conception in PCOS cases.
Patients suffering from diabetes are 3 times more likely to have depression, also more likely to have diabetic burnout affecting physical &mental health. Escitalopram effectively manages depression and comorbid diabetes by increasing serotonin level and insulin level improving glycaemic controls, also in long term improve HB1AC levels.
Deep brain stimulation is recent advancement in psychiatry utilized in several disorder that involves electric stimulus which is minimally invasive, safe, adjustable and reversible nerve involvement technology.
This first-of-its-kind survey conducted among ophthalmologists associated with AIOS presents the current practice patterns of ophthalmologists in India for prevention of endophthalmitis following cataract surgery.
Schizophrenia is common psychiatric disorder treated by typical and atypical antipsychotic. Atypical antipsychotics such as olanzapine, risperidone, quetiapine and aripiprazole are recommended for the patient with agitation, aggression, acute psychotic symptoms and prophylaxis. The efficacy and side effect of antipsychotics aids clinicians in choosing right antipsychotic.
Amongst patients with focal seizures, levetiracetam can be a good adjunctive to carbamazepine or phenytoin when patients fail to achieve adequate seizure control with monotherapy
This post hoc analysis of TRANSITION study demonstrated a rapid and significant reduction in NT-proBNP, and favourable outcomes in patients with ADHF when sacubitril/valsartan was initiated in-hospital. Early in-hospital initiation of sacubitril/valsartan maybe beneficial in this patient subgroup.
The present study evaluated the safety, feasibility, and clinical efficacy of enhanced recovery after surgery (ERAS) in patients undergoing radical gastrectomy. The study demonstrated that ERAS was associated with significant clinical and economic benefits in gastric cancer patients undergoing radical gastrectomy.
Both ketorolac and the combination of ketorolac plus tramadol/acetaminophen showed good control of pain following the third molar surgery, the pain difference between the two was small and not relevant clinically. Use of combination was associated with extra cost and increased adverse events.
In India, providing In-person healthcare is challenging, given the large geographical distances and limited resources. Telemedicine can provide an optimal solution in pedaitric practice in these times as it allows pediatricians to deliver their services for diagnosis, treatment of diseases, for research, evaluation, and for continuous education with the help of information and communication technologies. Find out more views from an expert panel about the advantages of telemedicine in pediatric practice.
In India, providing In-person healthcare is challenging, given the large geographical distances and limited resources. In this type of scenario, telemedicine can provide an optimal solution as it allows health care professionals to deliver their services for diagnosis, treatment of disease, for research, evaluation, and for continuous education with the help of information and communication technologies. Find out more views from an expert panel about the practice of telemedicine and its advantages.
The systematic review and meta-analysis demonstrates 0.03% bimatoprost to be more effective for controlling IOP compared to 0.005% latanoprost 0.004% travoprost in patients with POAG and OHT. However, 0.005% latanoprost is better tolerated in patients with POAG or OHT.
Triple therapy with once-daily combination of tiotropium, formoterol and ciclesonide (TFC) significantly improved pulmonary function, symptoms, and quality of life in patients with chronic obstructive pulmonary disease (COPD), irrespective of their smoking history. The effects were more pronounced among non-smoker COPD patients, indicating a beneficial effect of adding inhaled corticosteroid to the bronchodilators.
COPD and cardiovascular diseases commonly coexist. In these patients, use of appropriately dosed bronchodilators is safe. In fact, optimized COPD therapy in high-risk patients reduces both respiratory and cardiac mortality.
This case-based session addresses many practical aspects in daily COPD management. Both the international and Indian experts shared their experience and highlighted how evidence can be translated in daily practice to optimize COPD management.
This study evaluated the efficacy and safety of zoledronic acid with or without methotrexate for the prevention and treatment of bone destruction rheumatoid arthritis(RA) patients. The study showed that zoledronic acid has a synergistic effect when combined with methotrexate, inhibiting RA disease activity, reducing fracture risk, and improving quality of life in RA patients with secondary osteoporosis.
Combined ultrasound (US) with radiography offers promising result for the diagnosis of obstructive ureteric stone in patients presenting with acute flank pain to the emergency department. The combined modality approach might reduce the need for computed tomography (CT) scan, thereby reducing the radiation exposure to the patient.
The newly developed highly purified HP-HMG preparation was non-inferior to the conventional HP-HMG in the number of oocytes retrieved in women undergoing IVF using the GnRH antagonist protocol. The clinical efficacy and safety profile of this formulation was comparable to the conventional preparation.
Allergic disorders like allergic rhinitis (AR) and urticaria are now being recognised as global health problems affecting millions of children worldwide. Although not life-threatening, the consequences of these conditions are not trivial. Antihistamines targeting the histamine H1 receptor play an important role in improving and maintaining the quality of life of patients. Despite having efficacy, 1st generation antihistamines are not preferred instead 2nd generation oral antihistamines are recommended as first line treatment for allergic diseases. Take a view of the excerpt to know the reasons why first generation antihistamines are a less preferred option.
Allergic disorders like allergic rhinitis (AR) and urticaria are now being recognised as global health problems affecting millions of children worldwide. Although not life-threatening, the consequences of these conditions are not trivial. Allergies impose a substantial socio-economic burden on patients, their families and society and they have a negative impact on patient's quality of life. Find out the expert's opinion on the epidemiology and impact of these disorders in children.
The present study compared the outcomes of early stoma closure with conventional stoma closure following bowel surgery. The study showed that early stoma closure was not associated with an increased risk of postoperative complications and leads to better a quality of life.
Warfarin remains the gold standard oral anticoagulant (OAC) in the Indian clinical practice. In the era of newer OACs, warfarin still has wider real world clinical use.
This study evaluated the efficacy of oral third generation cephalosporin-cefixime given as a single dose to outpatients with a confirmed community-acquired infection. The study showed that cefixime demonstrated good efficiency in patients with community-acquired infections suffering from acute otitis media, lower respiratory tract infections and in uncomplicated urinary tract infections.
This updated systematic review and meta-analysis demonstrated that use of glucose lowering drugs or strategies reduced the risk of fatal and non-fatal atherosclerotic events in individuals with type-2 diabetes mellitus or at risk of the disease.
This review provides you a brief insight on useful predictors in analysing the presence of detrusor overactivity in male patients with lower urinary tract symptoms.
ENSURE was the first and largest trial to prospectively investigate erlotinib versus chemotherapy in a broad Asian population. The study showed that erlotinib provides a statistically significant improvement in progression-free survival compared with gemcitabine/cisplatin in Asian patients with epidermal growth factor receptor mutation-positive non-small-cell lung cancer patients.
The present study evaluated the efficacy and safety of Er: Glass laser used in combination with topical 5% minoxidil versus 5% minoxidil alone for the treatment of male androgenetic alopecia. The study demonstrated that treatment with combination therapy resulted in superior clinical outcomes of hair growth compared to monotherapy.
In the era of increasing resistance of Antibiotics, how High Dose of Minocycline plays a pivotal role to manage gram negative Bacilli. Dr Vishnu Rao an Infectious Disease expert from Apollo Hyderabad shares his experience of High Dose Minocycline in the current era & how dose optimization of Minocycline IV Is the need of the hour .
Sacubitril-valsartan treatment was associated with improvement in indices of vascular compliance as ascertained by echocardiographic evaluation. The echocardiographic biomarkers can be potentially used to assess the effectiveness of sacubitril-valsartan in HFrEF patients.
A webinar on long term effectiveness of viscosupplementation with various types of Intra-articular Hyaluronic acid in Osteoarthritis in maintaining functional improvement of the knees.
Amongst glaucoma patients, those with NTG prominently exhibit signs of vascular dysfunction. Hence a combination of conventional and advanced assessment techniques may be important to understand the role of non-IOP-related factors associated with NTG in these patients.
This is the first study from India which reports that full dose of pirfenidone ie 2400mg/d offers a significant survival advantage in idiopathic pulmonary fibrosis (IPF) patients. About 42% of the study subjects tolerated the full dose of pirfenidone (2400 mg/day), while 29.6 of the study subjects tolerated a dose of 1800-2400mg/day.
This Webcast focuses on the role of Enzalutamide, a second generation androgen receptor inhibitor for the treatment of men with metastatic prostate cancer. It covers advances in management of mCRPC and mCSPC and provides practical tips while prescribing Enzalutamide. The speaker also covers decision making algorithm in management of metastatic prostate cancer.
The present randomized clinical trial studied the effect of remdesivir vs standard care on clinical outcomes at 11 Days in patients with moderate COVID-19 patients. The study showed that the 5-day course of remdesivir had a statistically significantly better clinical status compared with those randomized to standard care at 11 days after initiation of treatment in patients with moderate disease.
The LACONORTE study provides real-world data on the efficacy and safety of lacosamide when used as a first add-on therapy for treating patients with focal onset epilepsy.
This is the largest study that provides a direct comparison of vitamin K antagonists and direct oral anticoagulants used for the management of patients with chronic thromboembolic pulmonary hypertension, following pulmonary endarterectomy.
The mortality rate of patients with COVID-19 under mechanical ventilation is high. Treatment with remdesivir resulted in improved survival outcomes in these patients.
Antihistaminics should be the first choice of treatment in patients with allergic rhinitis (AR). Montelukast should be combined with antihistaminics in resistant AR cases.
Allergic disorders like allergic rhinitis (AR) and urticaria are now being recognised as global health problems affecting millions of children worldwide. Although not life-threatening, the consequences of these conditions are not trivial. Various guidelines recommend second generation oral antihistamine as first line treatment for symptomatic control of these disorders. Take a look at the expert's opinion stating these guideline recommendations on treatment of AR and urticaria in children.
Allergic disorders like allergic rhinitis (AR) and urticaria are now being recognised as global health problems affecting millions of children worldwide. Although not life-threatening, the consequences of these conditions are not trivial. Second generation oral antihistamines are preferred choice in treatment of such diseases. Bilastine is a most modern, second-generation antihistamine approved for use in children with allergic rhinoconjunctivitis and urticaria. It has the highest number of desired features for a modern antihistamine according to international ARIA guidelines. Take a look at the expert's comments on various positive attributes and efficacy of bilastine.
Allergic disorders like allergic rhinitis (AR) and urticaria are now being recognised as global health problems affecting millions of children worldwide. Although not life-threatening, the consequences of these conditions are not trivial. Second generation oral antihistamines are preferred choice in treatment of such diseases. Bilastine is a most modern, second-generation antihistamine approved for use in children with allergic rhinoconjunctivitis and urticaria. It has been shown to have an efficacy similar to that of other second-generation oral H1 antihistamines and an excellent safety profile with minimal sedative effect. Take a look at opinion of an allergy expert on various safety aspects of bilastine in children.
There are conflicts in terms of what is recommended for diagnosis of airway diseases and what is currently practiced. This lecture highlights important clinical aspects to optimize diagnosis and monitoring of airway diseases in current era.
This study provides you a brief insight on the efficacy and safety of intravesical BCG instillations when used in patients with Non-Muscle-Invasive Bladder Cancer, presenting with asymptomatic bacteriuria (ABU).
According to the findings of the CREDENCE trial, canagliflozin rendered protection against renal and cardiovascular outcomes in type-2 diabetes mellitus patients with albuminuric chronic kidney disease.
Degarelix was non-inferior to goserelin in achieving and maintaining testosterone suppression at castrate levels with an acceptable safety profile during 1-year treatment in the Chinese patients with prostate cancer. Treatment with degarelix resulted in improved disease control, indicated by significantly higher prostate-specific antigen progression-free survival (PSA-PFS).
Random-start controlled ovarian stimulation (COS) was as effective as conventional-start COS in fertility preservation in cancer patients. Random-start COS significantly decreased the total time for an IVF cycle without affecting the oocyte yield, maturity or competence. This protocol would minimize delays and allow more patients to undergo fertility preservation and still proceed with cancer treatment within 2–3 weeks.
EURTAC is the first prospective head to- head phase 3 study comparing the efficacy and safety of first-line erlotinib with platinum-based chemotherapy in non-Asian patients with advanced NSCLC and EGFR mutations. The study showed that erlotinib could improve median progression-free survival in European patients with EGFR mutation-positive NSCLC compared with standard chemotherapy.
According to this post hoc analysis of the CANVAS program, use of canagliflozin vs. placebo, along with other background antihyperglycemic agents (AHA) was associated with a lesser likelihood of initiating insulin or new AHA in T2DM patients.
Canagliflozin reduced the risk of renal and CV events consistently across a broad range of eGFR including an eGFR of 30 to <45 ml/min per 1.73 m2. These findings support the use of canagliflozin even in T2DM patients with a lower eGFR.
According to the post hoc analysis of the CANVAS Program, canagliflozin, when added to glucagon like peptide-1 receptor agonist (GLP1 RA) exerted a synergistic impact on the intermediate cardiometabolic markers in T2DM patients.
The CANVAS Program demonstrates that canagliflozin reduces the risk of CV events in type-2 diabetes patients who are at high risk of CVD.
In the era of increasing resistance of Antibiotics, how High Dose of Minocycline plays a pivotal role to manage gram negative Bacilli. Dr Chandrashish Chakravarty a Critical Care expert from Apollo Kolkata shares his experience of High Dose Minocycline in the current era & how dose optimization of Minocycline IV Is the need of the hour .
In this video, the speaker has discussed complexity of tibial plateau fracture fixation along with case discussion.
Dr Vijay Chopra talks about benefits of MRA in heart failure management.
Dr Vijay Chopra talks about the importance of the time of initiation of MRA.
Dr Vijay Chopra talks about the role of spironolactone in HFpEF patients.
Dr Vijay Chopra talks about the role of eplerenone in heart failure.
In the era of increasing resistance of Antibiotics, how High Dose of Tigecycline plays a pivotal role to manage gram negative Bacilli. Dr RP Gupta a Critical Care expert from Neuro One Hospital , Trichy shares his experience of High Dose Tigecycline in the current era & how dose optimization of Tigecycline IV Is the need of the hour .
The post hoc analysis of PARAGON-HF study demonstrated renal benefits of sacubitril/valsartan vs. valsartan alone in patients with HFpEF. Patients treated with sacubitril/valsartan had reduced risk of renal events and attenuated eGFR decline vs. those treated with valsartan.
The present prospective, multicenter, randomized open-label, 2-arm, phase-3 trial compares the 48-week virological efficacy of two drug regimens containing abacavir/lamivudine plus either raltegravir twice a day or darunavir/r once a day in HIV pastients with advanced disease. The 48 weeks results showed that the rate of virologic success was higher than 65% in both arms with a median CD4 cell count >200/μL at week 48.
There was no evidence on standard of care antibiotic regimen being non-inferior to meropenem for treating critically ill premature infants with late onset sepsis (LOS). Meropenem should therefore be reserved for neonates who would more likely have Gram-negative LOS.
Fluid overload is responsible for structural and functional alterations in diabetes patients with non-dialysis dependent stage 5 CKD. Early evaluation of structural and functional cardiac abnormalities and volume status in such patients is therefore crucial.
Omalizumab therapy significantly improved the lung function and decreased the blood eosinophil counts in adolescents with moderate-to-severe uncontrolled asthma. The results of this post hoc analysis highlight the potential effect of omalizumab therapy in adolescents whose asthma is not controlled with the current therapies and the need to optimize treatment early in the disease course.
A webinar to discuss the current concepts in Infertility treatment. IVF Experts present lectures on current concepts of ART Prework & Negative FNAC followed by a panel discussion on Obstetrics Complications in ART pregnancies.
A live Webinar to discuss the current concepts in Infertility treatment. IVF Experts will present lectures on current concepts of ART Prework & Negative FNAC in azoospermia followed by a panel discussion on Obstetrics Complications in ART pregnancies.
The present single-center retrospective trial gives a comparison between efficacy of Hydrodistension and Pentosan polysulfate combination vs. Pentosan polysulfate monotherapy based on the aspects of compliance and therapeutic outcomes in female IC/BPS patients.
Majority of pediatric patients with eosinophilic esophagitis remain in histological and clinical remission when treated with proton pump inhibitors (PPIs) for one year. The treatment with PPIs was found to be safe in this patient population.
Favipiravir is a novel antiviral approved in 2014 by Japan for the treatment of novel or re-emerging pandemic influenza virus infections. In the wake of the pandemic it has been repurposed for use in patients with COVID-19. This booklet is a compilation of the most frequently asked questions on the use of Favipiravir in COVID-19
Favipiravir is a novel antiviral approved in 2014 by Japan for the treatment of novel or re-emerging pandemic influenza virus infections. In the wake of the pandemic it has been repurposed for use in patients with COVID-19. This product monograph provides an overview of the available pharmacokinetics and clinical studies evaluating the safety and efficacy of favipiravir in patients with COVID-19
The SWISS trial is a randomized double-blind study that compared the symptom resolution effect of diclofenac with norfloxacin in women with uncomplicated lower urinary tract infection. The study showed that diclofenac was inferior to norfloxacin in terms of symptom resolution.
A practical insight into the evolving role of favipiravir in the current times.
With the evolving science of nebulization with respect to current pandemic, using the preferred patient-device interface like mouthpiece would decrease wastage of exhaled aerosol during nebulization. This would increase pulmonary drug deposition and also increase safety profile of inhaled medication.
With the evolving science of nebulization with respect to current pandemic, adherence to nebulization is most important aspect for optimal therapy through safe nebulization.
With the evolving science of nebulization with respect to current pandemic, cleaning and disinfection of nebulizer accessories after each use is the most important and integral of nebulization as it would safe guard the health of doctors, patients, caregivers and bystanders.
With the evolving science of nebulization with respect to current pandemic, patients can continue to use nebulization at home as prescribed by their physician. Performing nebulization at home safely is the need of the hour.
The current pandemic scenario has impacted ophthalmology in many ways. In the background of reduced patient load, dwindled revenues, infection risk, IPC protocols, etc. this would be an ideal time to facilitate the integration of quality standards to improve our practice image, branding and patient satisfaction.
In the management of STEMI in India, pharmacoinvasive strategy involving thrombolytics is the preferred therapy in cases of delays in primary PCI. Third generation thrombolytics such as tenecteplase offer ease of administration with single bolus IV dose.
The rate of recurrent Pseudomonas aeruginosa (PSA) infections in allogeneic hematopoietic cell transplantation (allo-HCT) recipients is high. The findings suggest that a targeted antibiotic treatment for a minimum duration of 14 days might prevent recurrent infections. However, more prospective studies are warranted to confirm these findings and define the optimal duration of treatment to prevent infection recurrence.
The combination nasal spray containing azelastine hydrochloride (AZE) and fluticasone propionate (FP) had a more rapid onset of action of 5 mins and was more effective than monotherapies of loratadine and intranasal FP in patients with allergic rhinitis (AR).
In the era of increasing resistance of antibiotics, high dose of minocycline plays a pivotal role to manage gram negative Bacilli. Dr Sanjith Saseedharan, a Critical Care expert from S.L Raheja Mumbai, shares his experience of High Dose Minocycline in the current era & how dose optimization of Minocycline IV Is the need of the hour .
Androgen-receptor-axis-targeted (ARAT) agents improve the overall survival outcomes in patients with metastatic castration-sensitive prostate cancer. The findings of this meta-analysis discourage the concurrent or sequential use of both docetaxel and an ARAT agent regardless of the tumor volume or other factors.
This article gives you an insight on persistence of overactive bladder (OAB) and urgency urinary incontinence (UUI) in patients with post-prostate incontinence (IPT) with an emphasis on discrepancies in surgical intervention vs radiation.
The present trial compared the efficacy and safety outcomes of remdesivir 5 Days verses 10 Days in treatment of patients with severe Covid-19 disease
The study demonstrates the benefits of lamotrigine in terms of alleviating clinical symptoms and improving cognitive function in patients with depression of recurrent bipolar disorder. This effect of lamotrigine may be mediated by alteration of serum inflammatory cytokines levels.
Bacteria have been identified as the main cause of pulp infection and periapical disease. This trial explained the role of octenidine as a root canal disinfection in the management of dental pulp infection due to Staphylococcus epidermidis.
An association between alterations in the oral cavity and systemic health has been widely proven. Oral disorders can be an expression of gastrointestinal disease. This study talks about the prevalence of oral manifestations among pediatric GERD patients.
Posttreatment endodontic pain has been reported in 25%–40% of all endodontic patients. Effective management of endodontic pain represents a continuing challenge. This trial explained the role of pre-treatment medication in controlling post endodontic pain
Impacted third molar extraction involves both soft and bone tissue trauma and may result in an acute inflammation with intense discomfort as well as pain. This study compared the efficacy of two different analgesics, Tramadol and Ketorolac after impacted mandibular third molar surgery.
Adolescents are at increased risk for caries and gingivitis. This study explained the impact of an interactive power toothbrush on plaque removal and its compliance among population.
This study explores the various bacterial isolates in patients with odontogenic infection and its antibiotic susceptibility to different antibiotics which are routinely used as prophylaxis in such types of infection in odontology.
The present study tested the hypothesis that preoperative education and breathing exercise training delivered within six weeks of surgery by physiotherapists reduces the incidence of postoperative pulmonary complication after upper abdominal surgery.
Guidance on lifestyle modifications and dietary habits to improve the overall lipoprotein profile.
Guidance to reduce lipid levels by lifestyle changes.
Dr Tiny Nair talks about the real benefits of MRA in SCD reduction.
Dr Tiny Nair talks about the right time to start with MRA.
Dr Tiny Nair talks about benefit of MRA depending on phenotype.
Dr Tiny Nair talks about various benefits of MRA's other than neuro hormones in heart failure patients.
Dr Tiny Nair talks about various benefits of MRA's other than diuresis in heart failure patients.
This substudy of the PARAGON-HF study demonstrates the favorable impact of sacubitril/valsartan vs. valsartan alone on various biomarkers related to ECM homeostasis in patients with HFpEF.
Switching over to esomeprazole therapy is associated with greater patient satisfaction and better symptom control in primary-care patients receiving proton pump inhibitor (PPI) therapy for gastro-oesophageal reflux disease (GORD).
The pregnant and reproductive aged non-pregnant women infected with SARS-CoV-2 had comparable clinical course and outcomes. The results of the study demonstrated no associations between pregnancy and severity of COVID-19, virus clearance time, and length of hospital stay. There was no evidence supporting vertical transmission of COVID-19 in the late stages of pregnancy, including vaginal delivery.
In patients treated with warfarin, dose-response to warfarin among patients is highly variable and depends on interpatient differences. Dose titration is based on periodic monitoring for assessing patient’s prothrombin time (PT) and International Normalized Ratio (INR) in order to ensure safety and efficacy of warfarin.
OPTIMAL is the first prospective head-to-head phase 3 study to examine the efficacy and safety of first-line erlotinib versus platinum doublet chemotherapy in patients with advanced NSCLC whose tumours harbour activating mutations in EGFR
This study presents the 1-years results of Giant-Cell Arteritis Actemra (GiACTA) trial that investigated whether tocilizumab resulted in higher rates of sustained glucocorticoid-free remission of giantcell arteritis than placebo through a period of 52 weeks.
In the management of STEMI in India, pharmacoinvasive strategy is the preferred therapy in cases of delays in primary PCI. Third generation thrombolytics such as Reteplase and Tenecteplase offer benefits like bolus dose and lesser bleeding events compared with streptokinase.
In the management of STEMI in India, pharmacoinvasive strategy is the preferred therapy in cases of delays in primary PCI. Third generation thrombolytics such as Reteplase and Tenecteplase offer benefits like bolus dose and lesser bleeding events compared with streptokinase.
In the management of STEMI in India, pharmacoinvasive strategy is the preferred therapy in cases of delays in primary PCI. Third generation thrombolytics such as Reteplase and Tenecteplase offer benefits like bolus dose and lesser bleeding events compared with streptokinase.
In the management of STEMI in India, pharmacoinvasive strategy is the preferred therapy in cases of delays in primary PCI. Third generation thrombolytics such as Reteplase and Tenecteplase offer benefits like bolus dose and lesser bleeding events compared with streptokinase.
In the management of STEMI in India, pharmacoinvasive strategy is the preferred therapy in cases of delays in primary PCI. Third generation thrombolytics such as Reteplase and Tenecteplase offer benefits like bolus dose and lesser bleeding events compared with streptokinase.
In the management of STEMI in India, pharmacoinvasive strategy is the preferred therapy in cases of delays in primary PCI. Third generation thrombolytics such as Reteplase and Tenecteplase offer benefits like bolus dose and lesser bleeding events compared with streptokinase.
In the management of STEMI in India, pharmacoinvasive strategy is the preferred therapy in cases of delays in primary PCI. Third generation thrombolytics such as Reteplase and Tenecteplase offer benefits like bolus dose and lesser bleeding events compared with streptokinase.
Topical CAI had a beneficial impact on ocular hemodynamics with increased ocular blood flow velocities and reduced vascular resistance in the primary retinal circulation, central retinal and short posterior ciliary arteries.
In this webinar conducted in collaboration with FOGSI, AMOGS & ICOG, the eminent panelists emphasize on one of the most challenging topics - “Nutrition” - to optimize women’s health via Nutriconnect.
Combination of letrozole and clomiphene citrate (CC) was associated with significantly higher ovulation rates than letrozole alone in women with polycystic ovarian syndrome (PCOS). Combination therapy may be an alternate low-risk, low-cost infertility treatment with superior ovulation rates.
In this video, the speaker has discussed complexity of unstable trochanteric fractures and tips and tricks for its fixation along with case discussion.
Amongst high-risk patients who underwent complex PCI, DAPT >12 months lowered the risk of ischemic events without any increase in bleeding risk as compared with DAPT ≤ 12 months. Long-term DAPT may favorably impact risk-benefit ratio in such high-risk population.
Presence of CVD (heart disease and stroke) and CKD lead to increased mortality and increased direct medical costs in diabetes patients over a period of 10 years. This adverse impact was additive and non-overlapping for any combinations of these diseases.
An Indian study presented at ATTD 2020 measured effectiveness of Digital Therapeutics WellthyCare in T2DM patients. Study showed significant reduction in blood glucose level indicating integrated personalised care can be effective tool for improving self-management, thereby enabling better glycemic control.
A mother may use one of several positions to hold her baby while breastfeeding. There is no one "best" position for every baby and mother; the best position is one that is comfortable for both and allows the baby to latch-on, suckle, and swallow easily. Here are some tips that can help a new mother to understand these positions in a lucid manner.
Watch eminent experts to know more about Urinary Tract Infection, the highly prevalent condition affecting females of all ages; and to understand the most effective way of management.
The present study evaluated the clinical effect of zoledronic acid in patients with cervical spondylosis and osteoporosis after anterior cervical discectomy and fusion surgery.
Use of povidone-iodine irrigation was associated with a 9-fold increased likelihood of penile prosthesis infection. The results demonstrated significant reduction in the infection rates when the irrigation solution was changed from povidone-iodine to vancomycin/gentamicin among men undergoing penile prosthesis placement in both primary and revision cases.
Global Experts in Heart Failure emphasize the importance of multidisciplinary approach for Heart Failure. They recommend the use of NT Pro-BNP as a biomarker for Heart Failure in high risk patients. They also recommend the essential pharmacological agents for the management of HF and the concerns associated with ARNI and how to address them.
Global Experts in Heart Failure emphasize the importance of multidisciplinary approach for Heart Failure. They recommend the use of NT Pro-BNP as a biomarker for Heart Failure in high risk patients. They also recommend the essential pharmacological agents for the management of HF and the concerns associated with ARNI and how to address them.
Global Experts in Heart Failure emphasize the importance of multidisciplinary approach for Heart Failure. They recommend the use of NT Pro-BNP as a biomarker for Heart Failure in high risk patients. They also recommend the essential pharmacological agents for the management of HF and the concerns associated with ARNI and how to address them.
Global Experts in Heart Failure emphasize the importance of multidisciplinary approach for Heart Failure. They recommend the use of NT Pro-BNP as a biomarker for Heart Failure in high risk patients. They also recommend the essential pharmacological agents for the management of HF and the concerns associated with ARNI and how to address them.
Global Experts in Heart Failure emphasize the importance of multidisciplinary approach for Heart Failure. They recommend the use of NT Pro-BNP as a biomarker for Heart Failure in high risk patients. They also recommend the essential pharmacological agents for the management of HF and the concerns associated with ARNI and how to address them.
Global Experts in Heart Failure emphasize the importance of multidisciplinary approach for Heart Failure. They recommend the use of NT Pro-BNP as a biomarker for Heart Failure in high risk patients. They also recommend the essential pharmacological agents for the management of HF and the concerns associated with ARNI and how to address them.
Global Experts in Heart Failure emphasize the importance of multidisciplinary approach for Heart Failure. They recommend the use of NT Pro-BNP as a biomarker for Heart Failure in high risk patients. They also recommend the essential pharmacological agents for the management of HF and the concerns associated with ARNI and how to address them.
Global Experts in Heart Failure emphasize the importance of multidisciplinary approach for Heart Failure. They recommend the use of NT Pro-BNP as a biomarker for Heart Failure in high risk patients. They also recommend the essential pharmacological agents for the management of HF and the concerns associated with ARNI and how to address them.
Global Experts in Heart Failure emphasize the importance of multidisciplinary approach for Heart Failure. They recommend the use of NT Pro-BNP as a biomarker for Heart Failure in high risk patients. They also recommend the essential pharmacological agents for the management of HF and the concerns associated with ARNI and how to address them.
The bacteriological and clinical efficacy of ceftriaxone, sulbactam, and disodium EDTA (AAE) in combination with colistin was significantly better than meropenem + colistin in the management of various nosocomial MDR Gram-negative infections. A significant proportion of patients who failed to respond to meropenem responded well to the AAE therapy highlighting the new hope to spare carbapenems.
Any critical error, body mass index (BMI) < 25 kg/m2 and high modified Medical Research Council (mMRC) were independent risk factors for frequent exacerbations in patients with chronic obstructive pulmonary disease (COPD). COPD patients, especially frequent exacerbators should be carefully monitored and educated about correct handling of inhaler devices.
Dimethyl fumarate demonstrated a sustained long-term efficacy and safety in patients with relapsing remitting multiple sclerosis who continued the treatment for 11 years.
This is a randomized control a trial comparing the efficacy of once-weekly ciprofloxacin with that of daily norfloxacin for the prevention of spontaneous bacterial peritonitis in liver cirrhosis patients with ascites
A child’s physical, mental, emotional and social health are important and they contribute to his/her well-being. Keeping a child healthy and well is always a priority of any parent. Here are some ways in which a parent can improve their child’s well-being.
This double-blind, randomized controlled trial investigated whether normal saline or a balanced crystalloid has distinct effects on vasopressor use in patients undergoing major abdominal surgery.
A fixed dose combination of dorzolamide/timolol rather than brinzolamide/timolol maybe a preferred choice in patients with primary open angle glaucoma and normal tension glaucoma, as the former provided better reduction in the intraocular pressure and was better tolerated than the latter.
The present study compared the effectiveness and safety profile of metronidazole and tinidazole in the treatment of amebic liver abscess.
With increasing awareness on the need for Accreditation and many eye care organisations starting their journey for NABH Accreditation, this webinar is the 1st Part of a two webinar series designed to convey the needs of Accreditation, step-by-step guidelines for implementation, infrastructure needs, hospital infection control guidelines, etc. in a nut shell by eminent NABH assessors.
The recently released ESC guidance document explains management encompassing the spectrum of CV care during the COVID-19 pandemic. Individuals with CV risk factors and established CV and cerebrovascular disease are a more vulnerable population when suffering from COVID-19.
Remdesivir was superior to placebo in shortening the time to recovery in adults hospitalized with Covid-19. The benefit was most apparent in patients with a baseline ordinal score of 5 (requiring oxygen).
Oral sildenafil appears to be a promising medication to treat persistent pulmonary hypertension in newborns in settings when nitric oxide is unavailable.
Cataract Kaleidoscope is an interactive webinar on how to deal with complex cataract surgery and manage complications. This event has roped some of the best cataract surgeons of the country who will discuss the various surgical scenarios through their instructive videos. This program brings to table, the most relevant and practical tips for managing complex cataract surgery.
This talk discusses the newer paradigms in COPD management, with focus on nebulised glycopyrrolate.
The 2020 CLSI Guidelines on Polymyxins have changed the MIC cutoffs, wherein it has removed sensitivity cutoff and just provides Intermediate and resistant cutoffs. The guidelines suggest the dosages which are to be followed for both colistin and polymyxin B and mentions use of these molecules in combination only.
A case based discussion on Management of Urosepsis in young patient.
Efficacy of pentosan polysulfate for the treatment of interstitial cystitis/bladder pain syndrome: results of a systematic review of randomized controlled trials
This webinar discusses the clinical efficacy and safety of Omalizumab use over the last 2 decades across the globe, while also getting insights from Indian experts on the perspective of use of Omalizumab in Indian patients.
In the era of increasing resistance of Antibiotics, how High Dose of Minocycline plays a pivotal role to manage gram negative Bacilli. Dr Senthur Nambi an Infectious Disease specialist from Chennai shares his experience of High Dose Minocycline in the current era & how dose optimization of Minocycline IV Is the need of the hour.
Fluticasone furoate was safe and effective in treating Japanese children (age 2 to <15 years) with perennial allergic rhinitis. The medication was generally well-tolerated and most of the children had low systemic exposure to the medication with 12 weeks of treatment.
Treatment with esomeprazole 20 mg once daily significantly achieved relief of nighttime heartburn symptoms and improved sleep quality, work productivity and functionality in patients with moderate-to-severe nighttime heartburn and gastro-esophageal reflux disease-related sleep disturbances.
This prospective, randomized, split-face, controlled study assessed the efficacy of a combination serum containing vitamin C, vitamin E, and ferulic acid as an adjuvant to QSNL laser treatment among patients with environment-induced lentigine and melasma.
The GnRH antagonists were associated with lower risk of overall mortality, cardiovascular and musculoskeletal events as compared to agonists, according to the data based from trials with a short-term duration. The incidence of adverse events and injection site reaction rates were lower with GnRH agonists. The PSA progression, serious adverse events and drop-out rates were similar with both these forms of androgen deprivation therapy.
The long-acting beta-2-receptor agonist (LABA) and long-acting muscarinic antagonist (LAMA) combination therapy was associated with reduced risk of exacerbations and hospitalizations in chronic obstructive pulmonary disease (COPD) patients who complain of dyspnea and/or exercise intolerance as compared to LABA or LAMA monotherapy
Tips on breathing exercises for COPD patients.
Informative patient education material highlighting the fact that frequent and chronic cough in children could be a sign of asthma.
Tips on diet for the COPD patients.
Informative patient education material to know more about chronic obstructive pulmonary disease (COPD).
Informative patient education material for better asthma management.
Vildagliptin with/without metformin as an add-on to insulin was effective in demonstrating good glycemic control and was well-tolerated, without any hypoglycemic events.
Mexiletine is a class 1B antiarrhythmic agent, which blocks the sodium channels and is indicated in suppression of ventricular arrhythmias. The Mexiletine FAQ booklet describes complete information of pharmacology and clinical usage of mexiletine in the management of ventricular arrhythmias.
In this webinar, Dr. Manoj Kumar Sahu, who is a renowned Gastroenterologist, Hepatologist and Advanced Therapeutic Endoscopist, helps us better understand the clinical approach adopted for management of rectal bleeding.
In this webinar, prominent gastroenterologist Dr. Ajay K. Jain will help us better understand how to avoid mistake and improve diagnosis in managing ulcerative colitis patients.
The speakers in this video explain about the new technique i.e. spinal endoscopic technique for Lumbar Transforaminal Interbody Fusion and its advantages over conventional surgical procedures.
In the pharmacological therapy for ventricular tachycardias (VT), mexiletine, a class IB agent, is preferred as add-on therapy in recurrent VTs despite standard treatment. A case report demonstrated the role of mexiletine in VT storm associated with myocardial infarction.
In the pharmacological therapy for ventricular tachycardias (VT), mexiletine, a class IB agent, is preferred as add-on therapy in recurrent VTs despite standard treatment. A case report demonstrated the role of mexiletine in VT storm associated with myocardial infarction.
In the pharmacological therapy for ventricular tachycardias (VT), mexiletine, a class IB agent, is preferred as add-on therapy in recurrent VTs despite standard treatment. A case report demonstrated the role of mexiletine in VT storm associated with myocardial infarction.
Key highlights in Hepatocellular Carcinoma of the American Society of Clinical Oncology (ASCO) 2020 Virtual Conference held from 29th to 31st May 2020.
This Webcast provides overview on usage of the New Antiviral Remdesivir introduced for treatment of COVID – 19 and Challenges in the management of COVID – 19 patients.
Semi-Line workshop on patented PCNL technology SUPERPERC.
This is a prospective, randomized, double-blind control trial evaluating the efficacy of platelet‑rich plasma with and without topical 5% minoxidil and compared with placebo and standard treatment in male‑type baldness
Various studies have taken a closer look at asthma & COPD and the comorbidities associated with them. Cardiovascular disorders have been found to be commonly associated with these obstructive airway diseases. This webinar explores the cardio-pulmonary linkage better and attempts to discuss how comorbidities impacts patient outcomes.
In this talk, Dr. Dasgupta explains the pleiotropic role of Interleukin-6 (IL-6) in Giant cell arteritis (GCA) pathogenesis, clinical benefits & therapeutic efficacy of Tocilizumab (IL-6 inhibitor) for treating GCA. Published data demonstrated that tocilizumab enables sustained remission with rapid glucocorticoid tapering over 6 months in GCA patients.
Glaucoma diagnosis and treatment is often difficult and not straightforward. “Glaucoma Crossfire Season 1” presents some challenging case studies in glaucoma management and will guide the practitioner to take informed decisions in various clinical situations.
The results of this small-scale study demonstrated a significant clinical improvement amongst patients hospitalized for COVID-19 when they were treated with compassionate use remdesivir for 10 days.
The results did not show statistically significant clinical benefits with the use of remdesivir in patients hospitalized for severe COVID-19. Nevertheless, there was a numerical reduction in time to clinical improvement in patients treated earlier with remdesivir.Remdesivir was well tolerated with no new safety concerns identified.
Efficacy of Solifenacin in relieving symptoms of OAB and information on its safety, tolerability and effects on cognitive function in elderly population.
The OPTIMSE trial demonstrates that reducing antihypertensive medication in elderly (aged 80 years and above) with SBP lower than 150 mmHg while on more than one antihypertensive medications, may not change the blood pressure substantially.
Daily dose of 10 mg montelukast resulted in an improvement in the common symptoms of allergic rhinitis (AR). The improvement in symptom severity score was maximum in sneezing and least in rhinorrhea.
The present study evaluated whether enzalutamide prolongs survival in men with castration-resistant prostate cancer after chemotherapy.
A substantial proportion of left ventricular thrombi patients receive off-label direct oral anticoagulants (DOACs). The RED VELVT study demonstrates a high risk of stroke and systemic embolism with DOACs vs. warfarin, thus challenging the off-label use of DOAC for this indication.
The present study evaluated the effect and safety of the current trend of increasing time interval between the end of chemoradiotherapy and surgery (< 10 weeks vs ≥ 10 weeks) on postoperative morbidity and pathological outcomes in patients with locally advanced rectal cancer patients
Various studies have said that Nebulization is not a Viral Aerosol Generating Procedure since the droplets are from the machine and not from the patient. However, sharing of nebulization accessories like facemask and mouthpiece is an unhygienic practice with a high-risk potential of spreading infection. This webinar talks about Nebulization therapy in the current era.
Global Experts in Heart Failure emphasize the importance of multidisciplinary approach for Heart Failure. They recommend the use of NT Pro-BNP as a biomarker for Heart Failure in high risk patients. They also recommend the essential pharmacological agents for the management of HF and the concerns associated with ARNI and how to address them.
Global Experts in Heart Failure emphasize the importance of multidisciplinary approach for Heart Failure. They recommend the use of NT Pro-BNP as a biomarker for Heart Failure in high risk patients. They also recommend the essential pharmacological agents for the management of HF and the concerns associated with ARNI and how to address them.
Global Experts in Heart Failure emphasize the importance of multidisciplinary approach for Heart Failure. They recommend the use of NT Pro-BNP as a biomarker for Heart Failure in high risk patients. They also recommend the essential pharmacological agents for the management of HF and the concerns associated with ARNI and how to address them.
Global Experts in Heart Failure emphasize the importance of multidisciplinary approach for Heart Failure. They recommend the use of NT Pro-BNP as a biomarker for Heart Failure in high risk patients. They also recommend the essential pharmacological agents for the management of HF and the concerns associated with ARNI and how to address them.
Global Experts in Heart Failure emphasize the importance of multidisciplinary approach for Heart Failure. They recommend the use of NT Pro-BNP as a biomarker for Heart Failure in high risk patients. They also recommend the essential pharmacological agents for the management of HF and the concerns associated with ARNI and how to address them.
Global Experts in Heart Failure emphasize the importance of multidisciplinary approach for Heart Failure. They recommend the use of NT Pro-BNP as a biomarker for Heart Failure in high risk patients. They also recommend the essential pharmacological agents for the management of HF and the concerns associated with ARNI and how to address them.
This webcast provides an overview on etiology of UTI complications & management of Urosepsis. Management of complicated UTIs with judicious use of antibiotics & understanding the antimicrobial stewardship in Urology.
A combined therapy of myoinositol (MI) and D-chiro inositol (DCI) in physiological plasma ratio (40:1) might be useful as the first line approach in PCOS overweight patients, who need to control insulin levels and increase ovarian MI content, reducing the risk of developing a metabolic disease.
The ARTEMIS-1 study demonstrates the efficacy of midazolam-nasal spray (MDZ-NS) to safely treat seizure clusters in epilepsy patients aged above 12 years in an outpatient setting.
Key highlights in Prostate Cancer of the American Society of Clinical Oncology (ASCO) 2020 Virtual Conference held from 29th to 31st May 2020.
One of the most difficult decisions in a pediatric cataract is to take decision on the IOL power, the webinar would provide an opportunity to learn from the experts the correct way to calculate the IOL power in children
In this video, the speaker has discussed complexity of terrible triad and tips and tricks for its fixation along with case discussion.
The nasal spray containing azelastine hydrochloride (AZE) and fluticasone propionate (FP) was safe and offered better symptomatic improvement as compared to AZE monotherapy in patients with allergic rhinitis (AR).
A smartwatch app may identify atrial fibrillation (AF) patients, based on an irregular pulse notification. Although the probability of receiving an irregular pulse notification was low, 84% of these notifications were concordant with AF.
Chronic disease place a tremendous burden on the patient and the caregiver. Management of the disease often begins at the diagnosis and ends with a prescription by the clinician. Yet for the patient and the caregiver, treatment is only the beginning of the management of the disease. There is a great deal of strain felt by the families of these patients to accommodate the needs of the sufferer. Watch this webinar to understand ways to extend care and support to patients beyond treatment.
This is the prespecified interim analysis and final analysis of overall survival in the PROSPER trial. PROSPER trial evaluated the efficacy and safety of enzalutamide compared to placebo in men with nonmetastatic, castration-resistant prostate cancer who were continuing to receive androgen-deprivation therapy.
This first-of-its-kind study compared the efficacy and safety of LY IGlar vs. IGlar in Indian and East Asian T2DM patients. The outcomes for this study population were generally similar to those observed in the total population of the ELEMENT 5 study.
This study compared the clinical and mycological cure rates of terbinafine with itraconazole in patients with tinea corporis and tinea cruris.
This is a 48-week subgroup analysis of evaluating the efficacy and safety of FTC/ TAF by the class of coadministered third agent (boosted PI vs unboosted third agent). In this study, FTC/TAF demonstrated high efficacy in along with renal and bone safety advantages regardless of the class of coadministered third agent
Hear from a leading Paediatric Pulmonologist on use of ICS LABA in pediatric asthma. A Guidline based approach in treating Uncontrolled Asthma.
This is a single-center propensity score matching study comparing surgical and survival outcomes of laparoscopic versus open distal pancreatectomy for pancreatic ductal adenocarcinoma (PDAC). The findings suggest LDP as feasible and safe for PDAC treatment
Key highlights in Colorectal Cancer of the American Society of Clinical Oncology (ASCO) 2020 Virtual Conference held from 29th to 31st May 2020.
After 2 years of treatment, tenofovir alafenamide (TAF) was as effective as tenofovir disoproxil fumarate (TDF) in suppressing hepatitis B virus (HBV) replication with no documented virologic resistance and associated with a better renal and bone safety profile as compared to TDF.
This large-scale Indian study demonstrates that use of intracameral (IC) moxifloxacin following M-SICS significantly reduces the rate of post-operative endophthalmitis. IC moxifloxacin is therefore recommended for endophthalmitis prophylaxis following M-SICS.
Switching to silodosin is an effective and safe therapy in yielding relief from LUTS due to BPH and improving quality of life in patients with unsatisfactory treatment response to other alpha 1 blockers.
Functional constipation (FC) is a common childhood problem. Polyethylene glycol (PEG) is a safe and effective option for long-term maintenance treatment for childhood FC. The treatment should be initiated immediately after disimpaction to avert FC relapse.
Serum progesterone is not likely to be a good biomarker for determining pharmacokinetics or dosing of vaginal progesterone in pregnancy for preterm birth prevention.
In this video, the speaker has discussed the importance of surgical technique-nailing in distal femoral fracture cases.
Statistics enables the clinician to form reasonable and accurate inferences from collected information, and sound decisions in the presence of uncertainty. Statistics are key to preventing errors and biases in medical research. This webinar will cover the key concepts of statistics and their applications in clinical practice.
Glycopyrrolate/formoterol fumarate metered dose inhaler (GFF MDI) 18/9.6 μg improved the pulmonary function and reduced the risk of exacerbations as compared to monotherapies and placebo in patients with moderate-to-very severe COPD. The benefits were greater in subgroups of patients with higher symptom burden and those with an exacerbation history.
Several disorders are well recognized as causes of secondary osteoarthritis. Interventions on modifiable risk factors improve not only the symptoms of Osteoarthritis but also affect the osteoarthritic joint as a whole.
A case based discussion on Management of recurrent UTI in young patient.
The current issue summarizes on how to measure blood pressure correctly for the management of hypertension from International Society of Hypertension (ISH) global clinical practice guideline for hypertension 2020.
This issue summarizes the lifestyle interventions recommended for the management of Hypertension by the ISH-global clinical practise guideline for hypertension -2020.
This issue highlights the role of lipid analyses for CV disease risk estimation for good therapeutic approach in primary prevention settings.
Current time is the time of transition and chaos. With face to face social interactions changing into virtual one, people are also battling loneliness. Eminent psychiatrists across the country talk about how to help patients cope with loneliness.
The treatment of women of child-bearing age with epilepsy is very challenging. The antiepileptic drugs have impacts on various factors including body weight, fertility, sexual functions, pregnancy etc. which should be considered before initiating the treatment in these patients.
Treatment with tenofovir disoproxil fumarate (TDF) for over 10 years was well tolerated, safe, and effective in patients with chronic hepatitis B (CHB) infection. TDF was effective in suppression of viral replication without development of resistance in CHB patients.
The present study reports the 2-year results of DASISION Trial that compared safety and efficacy of dasatinib versus imatinib in newly diagnosed chronic myeloid leukaemia (CML)- chronic phase (CP) The study showed that dasatinib demonstrated faster and deeper responses compared with imatinib in patients with newly diagnosed CML-CP.
Key highlights in lung cancer of the American Society of Clinical Oncology (ASCO) 2020 Virtual Conference held from 29th to 31st May 2020.
Key highlights in renal cell carcinoma of the American Society of Clinical Oncology (ASCO) 2020 Virtual Conference held from 29th to 31st May 2020.
Among the antiarrhythmic drugs, mexiletine, a class IB agent, has safer electrophysiological properties. This makes it effective drug, as an add-on to standard therapy, in the management of recurrent ventricular tachycardia.
Among the antiarrhythmic drugs, mexiletine, a class IB agent, has safer electrophysiological properties. This makes it effective drug, as an add-on to standard therapy, in the management of recurrent ventricular tachycardia.
Among the antiarrhythmic drugs, mexiletine, a class IB agent, has safer electrophysiological properties. This makes it effective drug, as an add-on to standard therapy, in the management of recurrent ventricular tachycardia.
Among the antiarrhythmic drugs, mexiletine, a class IB agent, has safer electrophysiological properties. This makes it effective drug, as an add-on to standard therapy, in the management of recurrent ventricular tachycardia.
Among the antiarrhythmic drugs, mexiletine, a class IB agent, has safer electrophysiological properties. This makes it effective drug, as an add-on to standard therapy, in the management of recurrent ventricular tachycardia.
Among the antiarrhythmic drugs, mexiletine, a class IB agent, has safer electrophysiological properties. This makes it effective drug, as an add-on to standard therapy, in the management of recurrent ventricular tachycardia.
The efficacy of l-arginine was comparable to tadalafil in the mild-erectile dysfunction (ED) population with a lower incidence of AEs. Combination therapy with both tadalafil 5 mg and arginine 2.5 grams once a day was superior to monotherapies alone in overall cohort and in patients with mild and severe ED.
Though intermittent exotropia remains one of the common type of strabismus seen in our country, lot of confusion remains in managing these patients starting from the target angle to be treated to the postoperative exercises, unilateral versus bilateral surgery and recurrences.
The speaker discusses the recent advances in the diagnosis and medical management of male infertility.
Challenges occur in every segment. Experts in ophthalmic fraternity discuss challenging cases in cataract, cornea & refractive surgeries.
Experts discuss the general anesthesia practices for eye setups post current pandemic situation.
In this webinar, doctor has explained various telemedicine guidelines, elements to be considered before beginning along with do’s and don’ts’ of teleconsultation.
Medical profession has its own ethical parameters and code of conduct. In this webinar, doctor has explained need of medicolegal laws during current different practical scenario.
DUs are a major clinical concern in SSc patients, occurring in 30% of the patients every year. This booklet summarizes the management of digital ulcers
Pregnancy represents an enormous cardiovascular challenge for patients with pulmonary hypertension (PH). Notably, PH is four times for more frequently encountered in women, with approximately 80% of the PH patients being in the childbearing age). This booklet summarizes the physiological changes in pregnancy and risk of PAH, followed by treatment approach in pregnant patient with PAH.
Pulmonary hypertension (PH) due to left heart disease (PH-LHD) is an emerging health concern, with increasing hospital admissions. PH-LHD is the most seen subset of PH, resulting from left ventricular dysfunction (systolic and/or diastolic) and/or valvular heart disease (VHD). This booklet summarizes the pathophysiology, diagnosis and management of PH-LHD.
Data from the REVEAL (Registry to Evaluate Early and Long-term PAH Disease Management) registry shows that hospitalization is an important outcome in PAH. Patients who were hospitalized for PAH are more likely to be re-hospitalized and have worse survival at 3 years than those who were not hospitalized. This booklet summarizes the clinical evidence of newer therapies like macitentan and ambrisentan plus tadalafil and its impact on hospitalization in patients with PAH.
In recent years, there has been a marked improvement in the treatment of pulmonary arterial hypertension (PAH) due to the development of targeted therapies, including the use of upfront combination therapy. This booklet summarizes clinical evidence on upfront combination therapies and its benefits in patients with PAH.
PAH in CHD has increasingly become a topic of discussion especially in center’s dealing with PAH patients. This booklet summarizes general aspects of including pathophysiology, types of PAH-CHD and management.
Although treatment advances have improved survival times from 2.8 years to 9 years from the time of diagnosis, PAH remains incurable. Risk assessment is thereby, recommended to guide treatment decisions and potentially improve morbidity and mortality. This booklet summarizes the clinical benefits observed by various studies that have followed risk stratification for treatment decision.
The ophthalmic fraternity is passing through unprecedented times. During and after the lockdown period, we should be able to tackle the various challenges. This webinar by a team of eye consultant will focus on these pertinent points.
In this video, the speakers have discussed the cases on complications arising due to osteoporosis during total knee replacement surgery.
Discussion from eminent faculty on diagnostic evaluation of patients with PH, emerging concepts, medical management of PH in 2020 & Cardiopulmonary rehabilitation in PAH.
Diabetes patients have a worse ocular surface damage as compared to no-diabetics, as evident form the ocular staining and conjunctival impression cytology tests. Dry eye assessment should therefore be essentially incorporated in the routine ocular assessment of diabetes patients.
Treatment of pneumonia with amoxicillin and cefpodoxime resulted in a similar response to therapy and the difference was not statistically significant. Both the groups showed a significant improvement in mean body temperature, respiratory rate and wheeze.
The results of the FLAME study showed that COPD patients with more severe health impairment and greater symptom burden at baseline experienced more exacerbations. The efficacy of indacaterol/glycopyrronium in reducing exacerbations was better as compared to salmeterol/fluticasone.
Key highlights in Breast cancer of the American Society of Clinical Oncology (ASCO) 2020 Virtual Conference held from 29th to 31st May 2020.
The speaker provides an extensive overview of various ART protocols as well as risk, importance and management of OHSS.
The ADVANCE trial compared the efficacy and safety of a triple-therapy combination of emtricitabine and dolutegravir (DTG) plus either of two tenofovir prodrugs - tenofovir alafenamide fumarate (TAF) or tenofovir disoproxil fumarate (TDF) against the local standard-of-care regimen of TDF - emtricitabine - efavirenz. The 48-week results showed that DTG, combined with TAF or TDF, was noninferior to the standard of- care regimen.
Various studies have determined that Nebulization is not a Viral Aerosol Generating Procedure since the droplets are from the machine and not from the patient. However, sharing of nebulization accessories like facemask and mouthpiece is an unhygienic practice with a high-risk potential of spreading infection. This webinar talks about Nebulization therapy in the current era.
IBS is one of the common GI disorders that significantly affects a patients quality of life. This talk will help to virtually approach IBS patients and provide them with the care they need.
Good nebulization practices are set of recommendations to perform nebulization in the most safe and effective way.
Levetiracetam has comparable efficacy and safety vs. carbamazepine as monotherapy for treating partial seizures. Nevertheless, levetiracetam leads to greater improvement in quality of life and can thus be considered as a better option over carbamazepine for partial seizures.
In this webinar, prominent gastroenterologist Dr. Malay Sharma will explain role of EUS in esophageal cancer including the applications, challenges, and limitations of EUS in the management of this disease.
In the era of increasing resistance of Antibiotics, how High Dose of Minocycline plays a pivotal role to manage gram negative Bacilli. Dr Dipnarayan Mukherjee and Infectious Disease specialist from Kolkata shares his experience of High Dose Minocycline in Meningitis & how the bactericidal action of High Dose Minocycline is the need of the hour.
Interventions on modifiable risk factors improve not only the symptoms of knee Osteoarthritis (OA) but also affect the osteoarthritic joint as a whole. Optimal management of knee OA should include, where possible, modification of risk factors through targeted interventions.
Initial salvage radiation therapy (SRT) prior to salvage hormone therapy (SHT) is beneficial in patients with prostate-specific antigen failure after radical prostatectomy and prolongs the time to treatment failure of bicalutamide as compared to SHT alone.
In this talk, Dr. B. S. Ramakrishna highlights the usage of probiotics in the treatment of IBS.
In this talk, Dr. B. S. Ramakrishna highlights the usage of antibiotics in the treatment of IBS.
In this talk, the doctor gives an overview of the indications, steps, concerns and advances in ICSI along with surgical videos for better clarity.
The world is passing through unprecedented times. This webinar focuses on the health of ocular surface and on the basic OT protocols.
Key highlights in hemat-oncology of the American Society of Clinical Oncology (ASCO) 2020 Virtual Conference held from 29th to 31st May 2020.
Integration of the echocardiographic parameters such as tricuspid annular plane systolic excursion (TAPSE), tricuspid regurgitation (TR) grade and inferior vena cava (IVC) was effective in stratifying the risk for all-cause mortality in pulmonary arterial hypertension (PAH) patients.
Hear from a leading Paediatrician how he manages Acute asthma in children, at his clinic, without a nebulizer.
The Ophthalmic fraternity is passing through unprecedented times. It becomes a necessity to come together to find ways and means of basic practice measures when it comes for Phakic IOLs that includes scope & post-operative evaluation.
Landmark trials like EMGT have shown that glaucoma patients may progress despite controlled intraocular pressure (IOP). Apart from IOP, ocular perfusion pressure/ low ocular blood flow (OBF) has been identified as an independent risk factor in glaucoma progression. This webinar focused on the role of OBF in glaucoma progression, how comorbid conditions may affect OBF, and role of medications in improving OBF and decreasing progression.
Pediatric Eye Trauma is one of the common case found in pediatric ophthalmologist OPD. This topic/presentation will demonstrate a wide spectrum of cases and their surgical management. Measures & precaution will be demonstrated during critical surgery cases of pediatric trauma. It is mainly video assisted skill transfer presentation to understand the pediatric anterior segment trauma.
Treatment of allergic rhinitis with 20 mg bilastine did not significantly impair the cognitive functions in individuals who require constant attention and are exposed to hypobaric hypoxia.
This study aimed to address whether higher dose of amoxicillin will lead to more rapid improvement. The study showed that acute bacterial sinusitis adults were more likely to improve rapidly when treated with immediate-release high dose of amoxicillin/clavulanate than with standard dose but not when treated with extended-release HD.
In this talk, the doctor provides various challenges and modalities to manage ovarian hyperstimulation syndrome, a serious complication associated with ART.
Dr N Murali Krishna highlights the current recommendations from guidelines on the screening, measurement and diagnosis of Hypertension. Moreover, he also touches upon the role of ambulatory BP measurement and out of office BP measurement, the goals of management, the choice of pharmacotherapy and the use of single pill combinations in the pharmacological management of Hypertension.
Irrespective of recent RCT demonstrating no effect of L rhamnosus GG in acute gastroenteritis, the current systematic review showed that L rhamnosus GG reduced the duration of diarrhoea and hospitalization in inpatients. These findings should be viewed in the context of the high heterogeneity and methodological limitations of the included trials.
The present issue provides the Intervention strategies as a function of total CV risk and untreated LDL levels suggested by ESC 2019 guidelines. These interventions will help patients with moderately high LDL-C( ≥160mg/dl) and high LDL-C (≥190mg/dl) levels to reduce the ASCVD risk.
The present issue provides the various CV risk categories recommended by ESC for the management of Dyslipidemia -2019. These risk categoires will help to identify those at high risk and prioritize their management strategies.
Hand hygiene is a great way to prevent infections. Cleaning hands at key times with soap and water or hand sanitizer is one of the most important steps one can take to avoid getting sick and spreading germs to those around you. CDC recommends washing hands with soap and water whenever possible but if unavailable, using a hand sanitizer with at least 60% alcohol can help avoid getting sick and spreading germs to others. Help your child's parents know when and how to clean their (and the child's) hands with hand sanitizier that will give them the best chance of preventing sickness.
Kangaroo care (KC) is a method of developmental care for babies using skin-to-skin contact with the parent. This method provides many parent-infant benefits. In developing countries, KC for low-birthweight infants has been shown to reduce mortality, severe illness, infection and length of hospital stay. Though the focus of KC was once on premature babies, recent research has shown that it has many benefits for all babies. Know how to do KC and its benefits.
Breast milk is the natural first food for babies; it provides all the energy and nutrients that the infant needs for the initial months. WHO and UNICEF have recommended initiation of breastfeeding within the first hour of life. While breastfeeding is a natural act, it is also a learned behaviour for both baby and mother. Here are some simple tips the new mothers can follow that will help in successfully breastfeeding their baby.
The currently available pharmacological treatments for osteoporosis are predominantly anti-resorptive. These inhibit osteoclast-mediated bone loss and therefore reduce bone turnover, and increase BMD because bone formation is permitted and bone resorption is inhibited. Teriparatide is a first in class, anabolic agent with a unique mechanism that results in increased bone formation.
This 5-year study evaluated the distribution and antibiotic sensitivity of bacterial isolates from ocular specimens with suspected microbial infections.
This study evaluates the invitro performance of the Revolizer at various inspiratory flow rates and the consistency of drug delivery across doses.
The present study assessed whether teriparatide (TP) could reduce refracture risk in osteoporotic vertebral compression fracture patients after vertebroplasty (VP) by comparing the radiological and clinical outcomes of cemented vertebrae with TP with those without TP. The study showed that TP treatment resulted in higher body heights and fewer refractures than VP alone, with comparable clinical outcomes 1 year after VP.
The Scandinavian Cohort Study provides real-world data on the risk reduction of renal events in T2DM patients newly treated with SGLT2 inhibitors vs. an active comparator (DPP-4 inhibitors).
The present issue summarizes the optimal recommendations for the management of hypertension from International Society of Hypertension (ISH) global clinical practice guideline for hypertension 2020.
Prevalence of LUTS in general population and gender-wise preponderance and age-group wise trend.
Causes of LUTS other than BPH and the differential diagnosis of BPH in a patient with LUTS.
Antibiotic Stewardship is necessary in the ICU & should be comprehensive as compared to other wards. ICU patient have high chances of developing antibiotic resistance if not used judiciously.
Watch this web series on Severe Asthma (2 parts) to know the evolution in the understanding of Biologics in Severe Asthma Management. Especially, Omalizumab is widely available in India and is getting acceptance increasingly due to its better clinical outcomes, safety and cost effectiveness in Severe allergic asthma management.
The present study compared the 3 regimens (azithromycin vs cefaclor vs amoxicillin) for the treatment of tonsillitis in children. The study demonstrated that 3 days of therapy with azithromycin at a dose of 10 mg/kg per day once daily showed an effective tendency for the treatment of paediatric tonsillitis with a lower occurrence rate of adverse reactions.
Evaluation of intravesical Bacillus Calmette–Guerin (BCG) treatment on outcomes of patients with T0 after repeat Transurethral resection of bladder mass (re-TURBT) with high-risk NMIBC.
The present issue summarizes the essential recommendations for the management of hypertension from International Society of Hypertension (ISH) global clinical practice guideline for hypertension 2020.
This eCME focuses on latest developments on the diagnosis and management of IPF
This eCME focuses on latest developments on the diagnosis and management of chronic hypersensitivity pneumonitis (cHP) including the role of mycophenolate mofetil in cHP.
Long-term treatment with 2 mg daily dienogest significantly reduced chronic pelvic pain and represents a promising medication for the long-term management of endometriosis. Dienogest also improved the quality of life and sexual function in women with endometriosis-associated pain.
The long-term treatment until menopause with 2 mg dienogest was well tolerated in women with symptomatic adenomyosis and could be a potential alternative in some patients, especially those with type 2 adenomyosis, to avoid hysterectomy.
Ciclesonide is a nonhalogenated synthetic ICS available in an extra fine formulation that has been approved for the treatment of persistent asthma. The extra fine formulation ensures that the drug not only reaches the central airways but also the peripheral airways, which is a major site of inflammation. As a result, the entire bronchial tree is targeted and minimal deposition occurs in the oropharynx which considerably improves the safety of the formulation. This monograph summarises the unique pharmacological properties & clinical evidences of Ciclesonide for the management of asthma. It also aims to discuss how this drug might be our answer to the quest for obtaining an ideal corticosteroid having optimum efficacy & high safety with the advantage of once daily dosing.
Organ donations are gradually increasing in India which is resulting in major focus on this. It is necessary to take utmost precautions for these set of immunocompromised patients who are susceptible to most infections due to low immunity.
Foracort Synchrobreathe is a novel breath-actuated inhaler with a dose counter. This booklet provides detailed information about the technical aspects of the inhaler and data from in-vitro and clinical studies to substantiate the effectiveness and patient benefits of formoterol/budesonide combination in Synchrobreathe inhaler.
Renal replacement is a challenging therapy & it is important to understand the etiology of the condition. Organ transplant is a very delicate & important procedure which requires utmost care as the patients becomes immunocompromised lifelong.
Swine Flu in the ICU patients is a very critical condition & it is important to understand the right Clinical Therapy. It’s vital to understand the patient category like Pregnancy. Flu prevention is an important way to reduce patients length of stay in the ICU.
Patients in the ICU are very critical & it is important to understand the right way to interpret the diagnostic reports & vital parameters; based on which the patient can be treated correctly. This will ensure decrease the patient’s stay in the ICU.
Expert talk by leading haematologist, Dr. M B Agarwal on Role of 2nd generation TKI in CML with focus on Dasatinib.
This study demonstrated the noninferiority of the novel combination of ceftriaxone, sulbactam, and disodium ethylenediaminetetraacetic acid (CSE) to meropenem in patients with complicated urinary tract infections (cUTIs) including acute pyelonephritis. CSE might be a potential alternative to carbapenems in patients with cUTIs including the infections caused by extended spectrum β lactamase producing gram-negative microorganisms.
The efficacy of ciclesonide (CIC) as a step-down therapy was significantly higher than budesonide (BUD) in patients well controlled on combination therapy. CIC had better drug adherence than BUD.
This webinar helps in understanding ciclesonide as a molecule. it’s unique properties and it’s therapeutic use in OAD management is discussed.
Inferior oblique surgeries are commonest surgeries after horizontal muscle surgeries in strabismus. This webinar discusses the various indications of the surgery and the effect of inferior oblique surgery on primary position, secondary position, torsion and unilateral surgeries.
Amongst T2DM patients, a six-month dose of 0.2 U/kg/day basal insulin yields effective glycemic control, states the post hoc analysis of the ORBIT trial. The study further identifies the patient characteristics that influence the basal insulin dose at six months.
The present randomized controlled trial assessed whether laparoscopic appendectomy for complicated appendicitis effectively reduces the incidence of postoperative complications and improves various measures of postoperative recovery in adults in comparison with open appendectomy. The study showed that laparoscopic appendectomy for complicated appendicitis is safe and feasible.
Atrial fibrillation (AF) patients who receive oral anticoagulants (OAC) should receive antiplatelet (AP) therapy only if clearly indicated for cardiovascular condition such as ACS, CAD and carotid occlusive disease. The study challenges the practice of coprescribing OAC plus AP in absence of a clear indication for AP in newly diagnosed AF patients.
It is imperative to re-think the way aerosol therapy is being practiced with a mindset shift from the rampant use of nebulizers to an alternative form of drug delivery. GINA and WHO Guidelines have recommended to avoid the use of nebulizers to reduce risk of transmitting viral infection. pMDI + Spacer is the first line of therapy for acute cases as per GINA, has been shown to be equivalent to nebulizer at a much lower dose, it is preferred by patients and requires minimal maintenance.
Allergic rhinitis (AR) is an organ-specific manifestation of allergic disease. It is rarely found in isolation and frequently has numerous associated comorbid disorders. AR is therefore part of a spectrum of allergic disorders that can profoundly affect the well being and quality of life of a child. Because AR is part of a systemic disease process, its management requires a coordinated approach rather than a fragmented, organ-based approach. Take a look at this comprehensive overview on comorbidities of AR in children.
Urethral stricture is an oft-encountered complication in a urologic setting faced, in conjunction with both common and uncommon causes. Thus, urethroplasty is a much-needed and highly differentiating tool in a practicing urologist’s surgical armamentarium. Know more on the art, skill and science of urethroplasty from a world-renowned and masterful exponent of this technique.
Adult epilepsy patients can be successfully switched from traditional sodium channel blockers (SCB) to lacosamide. Lacosamide exhibited similar efficacy as traditional SCB with a benefits of lower risks of hepatic enzyme induction and idiosyncratic adverse effects.
In this webinar, prominent gastroenterologist Dr. AS Puri helps us better understand how to manage ulcerative colitis patients who are either dependent on or refractory to steroid therapy by employing real-life case studies.
Learn about Refractive Cataract Surgery from eminent Ophthalmologists.
DOS Monthly webinar for knowledge upgradation of doctors, organized by Delhi ophthalmology society and Centre for sight.
This eCME focuses on the management of chronic thromboembolic pulmonary hypertension.
This eCME elaborates on CTEPH pathophysiology, risk factors, early diagnosis and prevention.
This eCME focuses on various management aspects beyond drugs like rehabilitation, exercise training and deconditioning, importance of vaccinations and prevention of infections and empowerment of both patients and parents in the caring of PH patients
This eCME focus on radiological modalities and imaging findings in the evaluation of pulmonary arterial hypertension.
This eCME briefly summarizes on various aspects of CTD-ILD including early diagnosis and management.This eCME briefly summarizes on various aspects of CTD-ILD including early diagnosis and management.
This eCME summarizes the various interventions for pulmonary hypertension
This eCME summarizes the etiology and pathobiology of PH in patients with underlying left heart disease.
DASISION study compared the efficacy and safety of dasatinib (100mg once daily), with that of imatinib (400 mg once daily) in patients with newly diagnosed chronic-phase chronic myeloid leukemia. The study demonstrated significantly higher and faster rates of complete cytogenetic response and major molecular response compared with imatinib.s
This webinar helps relook at aerosol therapy in the current situation with a focus on various inhaler devices including pMDI + spacer, BAIs for management of acute conditions and home management of OADs.
This webinar helps relook at aerosol therapy in the current situation with a focus on various inhaler devices including pMDI + spacer, BAIs for management of acute conditions and home management of OADs.
This webinar helps relook at aerosol therapy in the current situation with a focus on various inhaler devices including pMDI + spacer, BAIs for management of acute conditions and home management of OADs.
This webinar helps relook at aerosol therapy in the current situation with a focus on various inhaler devices including pMDI + spacer, BAIs for management of acute conditions and home management of OADs.
This webinar helps relook at aerosol therapy in the current situation with a focus on various inhaler devices including pMDI + spacer, BAIs for management of acute conditions and home management of OADs.
Presenting a multidisciplinary panel discussion on the new normal in respiratory practice. The panel covers the potential changes in delivering respiratory care in today’s scenario.
Expert talk by Dr. Dilip Walke on telemedicine for oncologists.
Expert talk by Dr. Dilip Walke on telemedicine for oncologists.
Expert talk by Dr. Dilip Walke on telemedicine for oncologists.
Expert talk by Dr. Dilip Walke on telemedicine for oncologists.
Expert talk by Dr. Dilip Walke on telemedicine for oncologists.
The Ophthalmic fraternity is passing through unprecedented times. It becomes a necessity to come together to find ways and means of precaution & safety for us, our associated healthcare teams & our patients.
Moses mode of Holmium laser lithotripsy was associated with significantly lower stone fragmentation/pulverization time and lower procedural time as compared to regular mode. The lower pulverization time could be related to lower retropulsion of stones with the Moses technology.
Enterotoxigenic Escherichia coli (ETEC) is the major bacterial pathogen causing acute watery diarrhea in children from countries of the developing world. ETEC diarrhea induces changes in immune responses in children. Although, zinc supplementation has been thought to improve immunity, limited data is available on its effect on immune responses in children with diarrhea due to ETEC. Take a glance at findings of a study evaluating immunological effect of zinc on children with ETEC diarrhoea.
Diagnosis of cough poses a common dilemma during consultations at primary care settings in India. A diagnostic strategy which involve step-by-step approach for the diagnosis and management of cough could bring in greater accuracy in the clinical assessment of cough and accelerate the process of appropriate referrals to specialty care.
This webcast provides overview about role of fosfomycin in VAP, sepsis and bacterial meningitis infection. Pharmacokinetics activity and adverse effects of this molecule are also discussed here.
Dr. Sujeet Rajan shares tips on respiratory practice and explains about precautionary measures/safety measures to be ensured by doctor community.
Dr. Sujeet Rajan explains the role of peak flow meter as a home monitoring tool for asthma management.
Despite the advances made in the management of obstructive airway diseases, achieving optimum control of asthma and COPD is still a challenge in the real world scenario with issues like suboptimal adherence to therapy, incorrect inhaler technique, over reliance on relievers and complex treatment regimens. This session focuses on advances and development of novel patient-centered approaches including customizing and simplifying intervention regimens, identifying barriers to device usage and improving adherence.
Silodosin has 583-fold higher selectivity for the alpha-1A subtype than alpha-1B subtype, thus is more uroselective than tamsulosin. Silodosin improves symptoms of BPH from the early stage of administration, both in new patients and those who have previously received tamsulosin.
Clinical pearls on disease understanding, diagnosis, treatment and referral in LUTS.
Home nebulisation is frequently prescribed for management of chronic airway diseases and is a valuable modality for elderly patients, having difficulties with hand-held inhalers, or having comorbidities. This panel discussion focusses on the changing perspectives and practices in home nebulization.
Provides an overview on minocycline use against CRE infection.
Provides an overview on how minocycline be used as a empiric therapy in acinetobacter cases
Provides an overview on safe use of minocycline over colistin
Provides an overview on how minocycline scores over colistin in VAP or HAP.
Provides an overview on tetracycline in Septicaemia cases.
Provides overview on use of minocycline in acinetobacter infection.
The ophthalmic fraternity is passing through unprecedented times. During and after the lockdown period, we should be in a position to tackle the various challenges, most importantly in glaucoma therapy. This webinar by a team of eye consultants will focus on these pertinent points.
The chronic pseudomonas infections are associated with the worsening of lung function. Early detection is necessary as some antibiotics may be useful in preventing the chronic infection. Although, most effective treatment yet to be determined, nebulized antibiotics can be a good option.
This randomized controlled trial investigated oxycodone preemptive analgesia in children undergoing endoscopic plasma total adenotonsillectomy. The study showed that oxycodone 0.1 mg/kg preemptive analgesia in combination with sufentanil postoperative analgesia was effective in the study population.
This handy resource guide briefly summarises the prevalence of idiopathic pulmonary fibrosis (IPF), its risk factors, diagnosis and clinical evidence showing that pirfenidone slows the disease progression in IPF.
Current concepts in Infertility treatment are discussed in this webinar. IVF Experts talk on current concepts of endometrial receptivity, ART Prework & Using Gonadotropins in daily practice; this is followed by a panel discussion on Obstetrics Complications in ART pregnancies.
Infantile esotropia is one of the common types of strabismus. Though an early surgery, helps with the early restoration of the visual axes, it would also lead to a better outcome in terms of binocular vision and function. However, there have been proponents of late surgery since they believe that the binocular vision would not be recovered and the child may require more than a single surgery and a late surgery may actually help but reducing the total number of surgeries.
In this video-based interactive webinar, speakers shared pearls for phacoemulsification in complex cataracts cases. Surgical tips for managing soft to rock-hard cataract, white, traumatic cataract, small pupil, floppy iris, and zepto precision nano-pulse cataract surgery in white intumescent cataract and pediatric cataract cases. Pearls for managing posterior capsule rent and difficult cases scenario were also discussed.
This webinar helps relook at aerosol therapy in the current situation with a focus on various inhaler devices including pMDI + spacer, BAIs for management of acute conditions and home management of OADs.
This e-RTD discusses the latest CLSI update on polymyxins and its implications in clinical practice.
Given the current scenario, it is essential to understand the emerging role of tele-medicine and tele-consultation in India. This session deals with the upcoming concepts in tele-medicine, and the medico-legal aspects which every doctor should be aware of.
Bronchiectasis is a heterogenous disease with multiple aetiology. There are around 100 potential cause for the pathophysiology of bronchiectasis. Finding of right treatment to right patient depending upon clinical practice is the basis of treatable traits.
Allergic rhinitis (AR) is a very common disease with a steadily increasing prevalence. It has a significant impact on the quality of life with a high economic burden on the affected person. Currently there are many potent and high quality drugs available for the treatment of AR. However, there are certain beliefs and dis-belief’s pertaining to AR and its management. This presentations elaborates on such myths of AR and presents the real facts with supporting evidences.
The study demonstrates that six-month zinc supplementation is a feasible and effective strategy for preventing growth retardation in children aged 6-24 months.
Gastroesophageal reflux (GERD) is a common presenting complaint in children and as such is complicated to manage, as symptoms are diverse and often difficult to interpret. Accurate diagnosis, appropriate management strategies, and timely referral to specialist are important principles in the effective management of GERD. However, there is a scarcity of literature and lack of published guidelines on GERD in children from India. Here are the results of a practice-based survey that was conducted amongst Indian paediatricians to obtain the disease trends, its diagnosis and management.
Levetiracetam does not impact the lipid profile and thyroid functioning in children with epilepsy as compared with carbamazepan which may lead to thyroid dysfunction. Levetiracetam monotherapy may thus be advantageous over carbamazepan in pediatric epilepsy patients.
The ophthalmic fraternity is passing through unprecedented times. This time is very important to use online medical journal to complete the research and exams. This webinar by a team of eye surgeons will focus on these pertinent points.
Optimized Medical Therapy (OMT) slows down the atherosclerotic disease, decreases future events of myocardial infarction, and longitudinally decreases mortality. OMT is as effective as revascularization strategy in management of stable CAD patients with moderate-severe
The novel intranasal spray containing azelastine hydrochloride and fluticasone propionate offered rapid, effective and sustained symptom control in Swedish patients with AR in a real-world setting, evaluated by visual analog scale as per the MACVIA-ARIA- endorsed language of AR control. The results were consistent irrespective of the disease severity, phenotype, age class or treatment history.
Treatment with pirfenidone resulted in significant improvements in objective 24-hr cough counts and subjective measures of cough in patients with idiopathic pulmonary fibrosis (IPF). These findings are of clinical significance to the IPF patients.
This is a prospective, randomized and controlled trial evaluating the effect of the modified long-axis in-plane ultrasound technique (M-LAINUT) in guiding radial artery cannulation. The study demonstrates that M-LAINUT can increase the first and total radial artery cannulation success rates, reduce the number of attempts, and shorten the total cannulation time in adults.
Respiratory hygiene is an infection prevention measure to decrease the transmission of respiratory illness like influenza, RSV, whooping cough or common cold. Even when a person is perfectly healthy, it’s important to practice proper cough and sneeze etiquettes. Here are some tips on simple hygiene practices your patients can take to prevent the spread of respiratory infections.
Patients have different opinion regarding duration of antibiotics use during the exacerbations. Some may prefer for longer duration and some for shorter. Due to unavailability of data comparing shorter and longer course of antibiotic, guidelines prefer to use antibiotics for 14 days during acute exacerbation.
In bronchiectasis, eradication treatment regimens for P. aeruginosa may vary, but some evidence suggests that use of inhaled antibiotics along with intravenous antibiotics achieve greater clearance of P. aeruginosa than intravenous antibiotics alone.
Understanding the etiology of Interstitial cystitis -Bladder Pain syndrome & UTI complications & taking necessary precautions against Urosepsis. How to treat complicated UTIs with judicious use of antibiotics & understanding the antimicrobial stewardship in Urology.
Pulmonary rehabilitation plays a vital role in improving symptom, thereby enhancing health-related quality of life in patients with chronic obstructive pulmonary disease. By improving pulmonary rehabilitation setup in Indian clinical practice, there would be enhanced QOL of COPD patients.
In this talk, the doctor gives a framework of changing concept of PCOS, from gynaecological curiosity to multiple system endocrinopathy, and a practical approach to management of PCOS associated infertility.
This eCME summarizes the key insights from Pro Kerala registry (from India) and compares with registries from western world.
This eCME focuses on various management armamentarium for PH.
This eCME focuses on various tools for early diagnosis of PAH in patients with underlying rheumatological diseases.
This eCME focuses on medical management of PH due to underlying left heart disease.
Allergic rhinitis is a common condition in children. Second generation oral antihistamine are first line treatment for allergic diseases. Bilastine is most recent antihistamine approved by DCGI, India. Take a look at the expert’s opinion about bilastine and its use in children.
Global Experts in Heart Failure recommend the use of NT Pro BNP as a tool for diagnosis and prognosis in Heart Failure. They recommend the use of Beta Blockers and ACEi/ARBs in all patients and up titrate to the maximally tolerated doses. They also recommend to switch from ACEi/ARBs to ARNI in patients who are worsening in spite ACEI/ARBs.
Global Experts in Heart Failure recommend the use of NT Pro BNP as a tool for diagnosis and prognosis in Heart Failure. They recommend the use of Beta Blockers and ACEi/ARBs in all patients and up titrate to the maximally tolerated doses. They also recommend to switch from ACEi/ARBs to ARNI in patients who are worsening in spite ACEI/ARBs.
Global Experts in Heart Failure recommend the use of NT Pro BNP as a tool for diagnosis and prognosis in Heart Failure. They recommend the use of Beta Blockers and ACEi/ARBs in all patients and up titrate to the maximally tolerated doses. They also recommend to switch from ACEi/ARBs to ARNI in patients who are worsening in spite ACEI/ARBs.
General protocol for following up with patients with BPH or LUTS.
Recommendation for Serum PSA test to Geriatric patients coming with other conditions such as Neurological, cardiological etc.
Diagnosis of patients with BPH symptoms but urine doesn’t show anything.
Pooled analysis of 3 phase III clinical trials demonstrated that treatment with pirfenidone reduces the risk of nonelective respiratory-related hospitalization over the course of 1 year in patients with idiopathic pulmonary fibrosis.
Salmeterol/Fluticasone is a widely-used ICS/LABA combination across the world for the treatment of asthma. This study discusses the efficacy of Salmeterol/Fluticasone in the Indian Population.
The small airways are known as the silent zone of the lungs and yet is a site of significant obstruction in asthma and COPD. This clinical booklet answers the key practice oriented questions related to small airways disease , it’s diagnosis and management with extra fine formulation of beclomethasone-formoterol, straight from the experts.
Superficial fungal Infections are caused by dermatophytes, also known as tinea. Tinea is a common fungal infection that can affect the skin, nails and hair. Tinea infection has a variety of clinical manifestations and affects all age groups, ranging from tinea pedis in adults to tinea capitis in pre-pubertal children.
Understanding the etiology of UTI complications & taking necessary precautions against Urosepsis. How to treat complicated UTIs with judicious use of antibiotics & understanding the antimicrobial stewardship in Urology.
Understanding the etiology of UTI complications & taking necessary precautions against Urosepsis. How to treat complicated UTIs with judicious use of antibiotics & understanding the antimicrobial stewardship in Urology.
As a childless couple approaches a fertility specialist, it is important to screen them to find out the reason of infertility and subsequently decide a process. Since there are various processes within fertility management, this session covers about various indications that makes patients suitable for IVF procedure.
Allergic rhinitis (AR) and asthma are both chronic heterogeneous disorders, with an overlapping epidemiology of prevalence, health care costs and social costs in quality of life. This presentation elaborates on the shared components of AR and asthma and also discusses about the challenges as well as the management approach in the patients with such co-existence.
Allergic rhinitis (AR) is considered as a major global health problem. Management of AR continues to revolve around allergen avoidance, medications that provide symptomatic relief, anti-inflammatory therapies, and AIT. This presentation elaborates on the recent advances in AR management including intranasal antihistamines and novel methods of deliveries etc. which continue to be the mainstay of therapy for AR.
Gastroesophageal reflux disease (GERD) is a common problem in children and it has been linked to multiple extraesophageal manifestations. Athough given the inherent unreliability in obtaining data from young patients exists, recent evidence has suggested that children with GERD face increased risk for otologic disease. Explore in detail about the findings on association between GERD and otlogic impairment in children….
Thyroid cancer is relatively uncommon compared to other cancers. This input describes the risk factors, symptoms, diagnosis and over all treatment for thyroid cancer. Also described are the ways to reduce the risk of thyroid cancer and early diagnosis.
Allergic rhinitis is an extremely common condition in children, affecting 10-40% of the young population worldwide, and around 10-20% in India. It is responsible for far more debilitation and interference with daily life of a child. However, data pertaining to its prevalence, diagnosis and management in Indian children, is scarce. Thus, a practice based survey was carried out amongst Indian paediatricians to obtain epidemiological aspects and trends in diagnosis and management. Take a glimpse at the results.
Read about how various lifestyle modification advices can improve quality of life of BPH patients and how delivering them in a structured rather than unstructured way helps much more.
Pharmacological therapy for ventricular tachycardias includes drugs like beta blockers, amiodarone as first-line agents in acute and chronic settings. Mexiletine, a class IB agent, is preferred as add-on therapy in recurrent VTs associated with ischemic cardiomyopathy, despite standard treatment.
Ophthalmic imaging is an integral part of the work of all ophthalmic departments. It allows the clinician to record the findings from clinical ocular examination in an objective, reproducible, transmissible and durable manner. Many ophthalmic imaging devices also facilitate identification of anatomical and disease features that are not readily visible with standard examination techniques and enable sophisticated quantitative analyses. As a result, ophthalmic imaging is essential to the diagnosis, treatment, and long-term monitoring of many ocular conditions.
Glaucoma has become the most frequent cause of irreversible blindness worldwide. An early diagnosis and management is essential to prevent glaucoma progression and vision loss in patients. This webinar, by a team of expert glaucoma specialists, will focus on the latest diagnostic techniques like OCT as well as practical tips for medical management of glaucoma. Also, it will highlight upon the laser procedures for managing primary angle closure disease.
A correct inhaler technique is required for the medication to reach the lungs, while using a pressurized-metered dose inhaler (pMDI). Patients who cannot master inhaler technique will benefit from adding a spacer. Spacers are intended to make inhalers easier to use and deliver medication more efficiently.
Spacer devices are add-on devices to be used with pMDI which help to overcome the co-ordination issues with pMDIs and help to extend the benefits of aerosol therapy across ages. This note provides details on advantages of spacers, benefits of pMDI+spacer therapy as an effective alternative to nebulizers, the right technique of usage and maintenance of spacers.
Let your patients Get Relief from Asthma………Today & Everyday. This simple Do’s and Don’ts poster for your patients will let them Breathe Freely…All Day Long.
Zinc supplementation shortened the time to discharge in children hospitalized for diarrhea. The benefits were evident in children aged 1-59 months, irrespective of their nutritional status.
This talk provides overview on use of flucytosine and key principles for safely using it in various infections like cryptococcal meningitis and candida.
For a patient with severe asthma the major cost burden is hospitalization due to an exacerbation, which can substantially increase the annual healthcare cost. Additionally, there is increased burden of high dose medications, oral steroids and the associated side effects with quality of life also being compromised. Omalizumab therapy helps to improve all these and thus reduces the cost of therapy significantly in long run.
Many patients on Omalizumab therapy for treatment of Severe Allergic Asthma tend to discontinue therapy due to high cost. This video highlights the benefit of Omalizumab therapy even after it is discontinued, post 1 to 1.5 years of administration. Hence, it is important to consider long term benefits and continue therapy as per the Drs advice.
This is the first equivalence study of antibiotics administered postoperatively in a large pediatric cohort. The study compared the safety profile of intracameral moxifloxacin (IC-Mox) ophthalmic solution 0.5% to subconjunctival antibiotics (SCAbs) in pediatric patients undergoing lens-related surgeries. Findings suggest that IC-Mox can be used safely in children for reducing the risk of endophthalmitis after cataract surgery.
This eCME focuses on newer updates on echocardiographic evaluation of PAH.
This eCME focuses on exercise training and its positive impact on general wellbeing of the patients with PAH.
This eCME focuses on indications, advantages and limitations of cardiac catheterization.
This eCME focuses on newer treatment strategies for improved clinical outcome and survival in patients diagnosed with pulmonary arterial hypertension.
Common cold, just as the name suggests, is one of the most common illnesses, and is a leading cause of doctor visits and missed days from school days in children. There is no proven treatment or prevention method for the common cold. Even a medication that is only partially effective in the treatment and prevention of the common cold could markedly reduce morbidity and economic losses due to this illness. Zinc has been evaluated as cold remedy in various studies. Take a glance at the evidence showing effect of zinc on common cold in children.
The latest CLSI 2020 guidelines are released which have given breakpoints for different antibiotics. Some revisions in the breakpoints have been discussed for molecules like Colistin, Fosfomycin & Minocycline. Experts from microbiology & Infectious Disease have put forward their views in the abstract.
Osteoporosis is preventable and treatable. However, being a silent disease, many people remain undiagnosed and go on to experience a fracture. Hence, possibility of osteoporosis and associated fracture risk can be considered based on the presence of co-medications increasing its risk.
Osteoporosis is preventable and treatable. However, being a silent disease, many people remain undiagnosed and go on to experience a fracture. Hence, possibility of osteoporosis and associated fracture risk can be considered based on the presence of conditions increasing its risk.
Microbial keratitis is a potentially vision threatening condition that requires prompt diagnosis and treatment to prevent untoward outcomes. The experts in the webinar would be presenting diagnosis and management of types of microbial keratitis and their approach towards the treatment of non-resolving keratitis.
Webinar on Medico-legal aspects and issues that an obstetric doctor could potentially experience in an obstetric emergency case, and how to deal with it.
Management of over active bladder and checking Urine flow and PVR volume.
Management of over active bladder.
Expert talk by Dr.Dilip Walke on Telemedicine for Oncologists.
TANGO I is a phase 3, multicenter, randomized, double-blind, double-dummy, active-control trial that compared efficacy and adverse events of meropenem-vaborbactam vs piperacillin-tazobactam for treatment of complicated urinary tract infection, including acute pyelonephritis. The demonstrated noninferiority of meropenem-vaborbactam for the treatment of complicated urinary tract infection.
Recent global estimates indicate that over a quarter of children under 5 years of age are stunted. Zinc is known to play a critical role in biological processes including cell growth, differentiation and metabolism. Deficiency in this micronutrient restricts childhood growth and decreases resistance to infections. This contribute significantly to morbidity and mortality in young children. Here are some evidences on the role of zinc supplementation in growth enhancement of children in zinc deficiency endemic area.
Cough is the second most common symptom reported by Chronic obstructive pulmonary disease (COPD) patients, which leads to significant distress and associated with adverse outcomes. This presentation consists of information about the role of cough in COPD, it mechanism and the relationship between cough and COPD exacerbations.
Osteoarthritis (OA) is the most common form of arthritis and is a major cause of debilitation for affected individuals. One of the nonsurgical options for the symptomatic management of OA is intra-articular injection of hyaluronic acid (HA), also referred to as viscosupplementation. A number of HA products, with distinct compositions, are available for the treatment of knee OA. These products are differentiated by their source of HA and method of production; the MW of the active ingredient; the amount, concentration, and injection volume per dose; and the number of injections per course of therapy, ranging from a single administration to up to 5 weekly intra-articular injections. As per the studies, non-animal stabilized HA is effective in reducing pain and improving function in patients with noninflammatory, mild-to-moderate knee OA.
In this talk, the doctor elaborates on telemedicine in India and the medicolegal aspects around it.
This is the 5th installment of self-paced e-learning modules course on 'Ocular blood flow and its relevance in glaucoma progression'. This module highlights the role of various anti-glaucoma medications in improving ocular blood flow in glaucoma patients and its impact in progression.
The ophthalmic fraternity is passing through unprecedented times. During and after the lockdown period, we should be in a position to tackle the various challenges, most importantly infection control. This webinar by a team of eye surgeons, NABH assessors and infection control will focuses on these pertinent points.
Pneumonia is a leading cause of morbidity and mortality in children less than 5 years age. Zinc is an important micronutrient that supports normal functioning of immune system. Chronic zinc deficiency in children can result into impaired immune function, leading to susceptibility to infections. Zinc supplementation has been found to have prophylactic as well as therapeutic role in childhood acute respiratory tract infections including pneumonia. View the slide set to know more.
Poorly controlled asthma is a staggering challenge in Indian scenario. Especially, a case based approach for treating Severe Asthma is the need of the hour. Based on the phenotype of the patient suffering from severe asthma the treatment strategy also changes. This webcast is an excellent feed to address this challenge.
In this talk, the doctor gives an overview of basic but important principles while approaching a couple to investigate and manage their infertility.
This is the 4th installment of self-paced e-learning modules course on 'Ocular blood flow and its relevance in glaucoma progression'. This module highlights the non-IOP risk factors for glaucoma like myopia, age, diabetes, hypertension, migraine. and provides an evidence-based approach for blood flow as predictor of glaucoma progression.
GLYCOHALE respules containing glycopyrrolate, is a newly developed long-acting muscarinic antagonist to be given via a high efficiency mesh nebulizer. Glycopyrrolate has been approved for the long-term maintenance treatment in COPD patients. Glycopyrrolate can be used to treat COPD as a monotherapy, as well as in combination with other drugs. The introduction of GLYCOHALE respules provides a valuable treatment option with the ease of a nebulizer for the chronic pharmacological management of COPD patients.GLYCOHALE is indicated for the long-term maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema.
This eCME focuses on the emerging role of antifibrotics in the management of progressive fibrotic interstitial lung diseases.
This eCME focuses on CT Imaging in interstitial lung diseases, how to secure the diagnosis especially the fibrosing ILD including chronic hypersensitivity pneumonitis and how computer aided diagnostics will change the reporting in future.
Asthma is one of the most common chronic diseases of childhood. The old concept of asthma being same type and can be treated the same way has limited progress in management of this disease. Here are some of the recent important developments in the diagnosis and management of pediatric asthma.
“Bisphosphonate holiday” is recommended in postmenopausal women with osteoporosis who are found to have low-to-moderate risk of fractures after taking bisphosphonates for 3 to 5 years.
This clinical practice guideline can be applied to a postmenopausal woman when considering the management of her osteoporosis. In addition to women with low-moderate fracture risk, women at high risk as being eligible for drug therapy are also considered in this.
Dr Frank Ruschitzka, an expert in heart failure shares his views on the global trends in management of heart failure.
Dr Frank Ruschitzka, an expert in heart failure shares his views on the global trends in management of heart failure.
Dr Frank Ruschitzka, an expert in heart failure shares his views on the global trends in management of heart failure.
Dr Frank Ruschitzka, an expert in heart failure shares his views on the global trends in management of heart failure.
Dr Frank Ruschitzka, an expert in heart failure shares his views on the global trends in management of heart failure.
Dr Frank Ruschitzka, an expert in heart failure shares his views on the global trends in management of heart failure.
Dr Frank Ruschitzka, an expert in heart failure shares his views on the global trends in management of heart failure.
Dr Frank Ruschitzka, an expert in heart failure shares his views on the global trends in management of heart failure.
Dr Frank Ruschitzka, an expert in heart failure shares his views on the global trends in management of heart failure.
This is the 3rd installment of self-paced e-learning modules course on 'Ocular blood flow and its relevance in glaucoma progression'. This module highlights advantages and disadvantages of various ocular blood flow measuring techniques with focus on color doppler imaging and OCT angiography.
This slide set provides a step wise diagnosis and management for difficult to treat and severe asthma patients, including the role and selection of appropriate biologics.
Know about the benefits to the patient and surgeon by this forward-looking technique as compared to conventional BPH surgical techniques.
Eye pain can have a variety of causes. It has a myriad of symptoms ranging from sharp pain in the eye to mild discomfort or itching in the eyes. As the spectrum of symptom presentation varies with eye pain, the cause of these pains may vary from very simple refractive errors to potentially sight threatening disorders like glaucoma and uveitis. The experts would be presenting their viewpoints on different clinical aspects of ocular pain.
In this talk, the doctor elaborates on the various factors responsible for negative IVF outcomes and how to manage these patients effectively.
IOP, we know is the main risk factor as well as the only modifiable factor in glaucoma today. Are there any other factors that we can identify & act on to prevent progression of Glaucoma? Yes, you'll be surprised how small things can alter the course of glaucoma in some patients. Add value to your Glaucoma practice by learning about these through this webinar.
In this talk, the doctor gives an overview of how to schedule IUI & IVF cycles making use of various hormonal options throughout the menstrual cycle.
Learning to use the toilet is an important milestone for children. A challenge to consistent toilet training is constipation which is a very common condition in children. Parents often have questions about how to proceed with training in case of constipated children. Here are some tips which will help them.
This study demonstrates a high burden of morbidity and mortality in the first year of life in infants with persistent pulmonary hypertension of newborn. The study also identifies various risk factors associated with adverse clinical outcomes in this patient subgroup.
The anatomic and functional relationship between upper and lower airways has been the object of great interest. Knowledge of respiratory diseases affecting both, the nose and lungs has helped us understand that these two parts of the respiratory system form a unique entity. This is commonly referred to as one airway one disease. Here is a glimpse of the factors supporting this concept.
The present cross-sectional study assessed the associations between mean ocular perfusion pressure (MOPP)and several variables including body mass index, comorbid medical conditions and various ocular parameters in a population-based sample. The findings suggest that migraine and elevated intraocular pressure increases the risk of low MOPP and this may have a causal relationship with impaired optic nerve head blood flow.
Evidence for ocular perfusion pressure as an independent risk factor for glaucoma progression. How low OPP/Blood Flow & impaired autoregulation impact glaucoma progression.
The CLSI 2020 latest guidelines have been released which have made some changes in the breakpoints of key antimicrobials. This webcast discussed about the key changes in the guidelines and how it would help to fight antimicrobial resistance.
The study showed that tamsulosin reduces nocturnal polyuria due to BPH by decreasing night time urine production over the long term. Probable underlying mechanism is by tamsulosin increasing daytime urine production by increasing daytime renal blood flow, which is deficient in NP patients.
Treatment with vibegron was associated with a significant reduction in the number of urgency urinary incontinence (UUI) episodes/d and significant increase in voided volume/micturition in patients with overactive bladder, including those with severe UUI, with response rate of more than 50%. Vibegron could be a useful therapeutic option in OAB patients with UUI.
The GINA 2020 strategy report represents important new recommendations for the management of asthma. The GINA guideline aims at reducing the risk of exacerbation and decreasing the frequency of symptoms of asthma.
Nebulized glycopyrrolate has well-tolerated safety profile in COPD patients for 48 weeks. Data from this study supports the use of nebulized glycopyrrolate as a potential additional treatment option to physicians for the management of COPD patients.
Nebulized glycopyrrolate has good efficacy and acceptable safety profile in COPD patients. Data from this study supports the use of nebulized glycopyrrolate as a potential additional treatment option to physicians for the management of COPD patients.
Bilastine is used in management of Allergic Rhinoconjunctivitis and Urticaria. Tested and trusted World wide by 104 countries. It is approved by DCGI, European and Japanese regulatory bodies.
Know about the urological and andrological complications of diabetes mellitus and their underlying pathophysiological mechanisms.
Maintaining hand hygiene is one of the best ways to protect oneself and the family from getting sick. Here are some tips your patients can follow on "when to wash his/her hands" to stay healthy.
Approach to status Post Prostatectomy with LUTS.
Artificial tears are commonly used for symptomatic treatment of dry eye disease (DED). The current study compared the efficacy and safety of two preservative-free lubricant eye drops; Osmodrops (carboxymethylcellulose 0.5%, glycerine 0.9%; Cipla Ltd.) and OptiveTM (carboxy1methyl cellulose 0.5%; Allergan Inc.) in patients with mild to moderate DED. The study concluded that both eye drops were found to be effective in decreasing the OSDI score and improving tear film stability in patients with mild to moderate dry eye symptoms.
This study discusses the in – vitro performance of the Huf Puf Kit which comprises of a anti-static spacer + mask and is a ready to use Kit for asthmatic children.
This study discusses the in – vitro performance of the Huf Puf Kit which comprises of a anti-static spacer + mask and is a ready to use Kit for asthmatic children.
The 2019 GINA strategy report represents the most significant change in asthma management in over 30 years. The 2019 GINA report includes important new recommendations for treatment of mild asthma and severe asthma.
It is observed, after a period of 72 h of initial stabilization, 83% of hospitalized patients would be unnecessarily receiving IV antibiotics, increasing the treatment costs by 200% in the case of some classes of antibiotics and prolonging hospital stay. IV to oral switch therapy, is a strategic component of an antimicrobial stewardship program to improve antibiotic use in hospitals. Find out how to identify the ideal candidtate, the ideal antibiotic and the benefits of switch therapy.
Eosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory disorder with its incidence and prevalence widely rising in all age groups including children. Treatment strategies include medical and dietary therapies. A clinical approach to EoE begins with an increased awareness of the disease and its manifestations.
Eri-001 study is a multicentre observational trial evaluating the safety and efficacy of eribulin monotherapy in different lines of therapy in locally advanced or MBC patients. The study showed that eribulin was a safe and effective treatment option for patients with advanced breast cancer
Dr Scott D Solomon, an Expert in Heart Failure shares his views on the global trends in management of heart failure.
Dr Scott D Solomon, an Expert in Heart Failure shares his views on the global trends in management of heart failure.
Dr Scott D Solomon, an Expert in Heart Failure shares his views on the global trends in management of heart failure.
Dr Scott D Solomon, an Expert in Heart Failure shares his views on the global trends in management of heart failure.
Dr Scott D Solomon, an Expert in Heart Failure shares his views on the global trends in management of heart failure.
Dr Scott D Solomon, an Expert in Heart Failure shares his views on the global trends in management of heart failure.
Dr Scott D Solomon, an Expert in Heart Failure shares his views on the global trends in management of heart failure.
This recent, peer-reviewed study determines the various advantages of TEmt device over monthly Foley catheterization.
Know how diabetes mellitus causes urological diseases and the underlying pathophysiological mechanisms responsible for it.
The latest CLSI 2020 guidelines are released, which have given breakpoints for Minocycline against Carbapenem Resistant Enterobacteriaceae (CRE). Minocycline should be tested against CRE as it has a susceptibility rate of more than 65%. CRE being one of the major hurdle in ICU, Minocycline could be a vital & an affordable treatment regimen.
Know about the various advantages of this technique and the modality it utilizes and importantly, how it could benefit your patients, from a recent, peer-reviewed study.
The present key trial is the first prospective study comparing the quadratus lumborum block (QLB) with transversus abdominis plane block (TAPB) for pain relief in patients undergoing laparoscopic colorectal surgery. The study showed that QLB is a more effective postoperative analgesia as it reduces sufentanil consumption compared to the TAPB in patients undergoing laparoscopic colorectal surgery
Know how to carry out these useful tests as well as the manoeuvres to increase their diagnostic ability in an outpatient setting.
In the era of increasing resistance to antibiotics, high dose of minocycline plays a pivotal role in managing gram negative bacilli. The need for using high dose minocycline over usual dose is been depicted in this infographic.
Understanding the etiology of UTI complications & taking necessary precautions against Urosepsis. How to treat complicated UTIs with judicious use of antibiotics & understanding the antimicrobial stewardship in urology.
Know about the benefits of Moses Holmium Lithotripsy.
The present randomised controlled trial evaluated the effects of the use of chlorhexidine compared to routine oral care in edentulous geriatric inpatients. The study findings showed that the use of chlorhexidine in the oral care was associated with a positive effect in reducing oral colonisation when compared to routine oral care of edentulous geriatric patients.
A substantial proportion of STEMI patients are treated with primary PCI beyond the recommended time frame (late pPCI). Implementing a pharmacoinvasive strategy at acute stage improved the five-year survival vs. the late pPCI and should be preferred when early pPCI is not feasible.
Importance of Risk stratification and Medical Management of Pulmonary Hypertension in practice
This input gives a brief on symptoms, triggers and complications of nasal allergy. Correct usage of nasal spray is also explained.
This is the 6th World Pulmonary Hypertension Symposium update on Hemodynamic definitions and updated classification of Pulmonary Hypertension.
This monograph describes the role of Flucytosine tablets in the management of invasive cryptococcal infections and some Candida spp. infections.
This eCME discusses new evidence regarding use of Isoniazid preventive therapy (IPT), Co-trimoxazole preventive therapy (CPT) and Fluconazole pre-emptive therapy in people with advanced HIV disease.
The present meta-analysis assessed the efficacy of prophylactic antibiotic treatment in acute pancreatitis. Results showed that prophylactic antibiotics in patients with acute pancreatitis reduced incidence of non-pancreatic infection and urinary tract infection. No benefits were seen in rates of infected pancreatic necrosis, mortality, surgical intervention, pneumonia, positive blood culture, and fungal infection.
The present trial evaluated the efficacy and safety of tigecycline monotherapy vs imipenem/cilastatin among hospitalized Chinese patients with cIAIs. The study demonstrated that tigecycline monotherapy was effective for the treatment of cIAIs.
This webcast provides us a brief overview on role of intravenous fosfomycin in VAP, UTI and sepsis, its efficacy, safety and susceptibility against resistant pathogen and drugs with which it can be used as combination therapy.
The webcast focusses on newer buzz in lung cancer i.e. Immunotherapy in lung cancer, EGFR Mutant lung cancer and Small cell lung cancer (SCLC).
There were no significant differences in the lipid and glucose metabolism in the patients of prostate cancer treated with degarelix and leuprolide after 6 months of androgen deprivation therapy. The patients treated with degarelix had significantly lower follicle-stimulating hormone levels.
In patients with small to mid-sized prostates, holmium laser enucleation of the prostate (HoLEP) was associated with longer operation time, less drop in hemoglobin levels, less blood transfusion, shorter hospital stay and shorter catheterization time as compared to transurethral resection of prostate (TURP). Superior long-term clinical outcomes were demonstrated by HoLEP in urodynamic parameters.
This is the first study to validate the IDSA/ATS guideline recommendations for the duration of antibiotic treatment among patients with CAP. The study demonstrated that the duration of antibiotic treatment based on clinical stability criteria can be safely implemented in hospitalized patients with CAP.
In this video, the speaker has discussed the trends in osteoporosis management in India.
This comparative trial assessed the efficacy of amoxicillin versus amoxicillin-clavulanate in preventing infectious complications after the surgical removal of the retained third molar. Findings showed both the antibiotics had similar efficacy in the prevention of infection, however, amoxicillin/clavulanate produced significantly more gastrointestinal discomfort.
This randomized controlled trial evaluated the effects of home intravenous (IV) versus oral antibiotic therapy on complication rates in children undergone appendectomy for perforated appendicitis. The study found that oral antibiotic therapy had equivalent outcomes and incurred fewer charges than IV antibiotics in studied population.
The montelukast-fexofenadine group had a significant decrease in the total nasal symptom score as compared to montelukast-levocetirizine group. However, montelukast-levocetirizine group had a lesser cost-effectiveness ratio as compared to montelukast-fexofenadine group.
Treatment with bilastine was effective in relieving pruritus associated with urticaria and other skin diseases and was safe and well tolerated.
Tadalafil daily was associated with better efficacy than on-demand tadalafil in men with erectile dysfunction after at least 24 weeks of treatment. Daily tadalafil was also safe and well tolerated, with a lower incidence of treatment-emergent adverse events as compared to on-demand tadalafil.
This is the first randomized-controlled clinical study that assessed the adjunctive effect of the metronidazole– amoxicillin antibiotic combination in the treatment of GAP. The findings indicated that metronidazole– amoxicillin the antibiotic combination resulted in clinically significant short-term improvements in clinical parameters.
This webcast provides us a brief overview on role of intravenous fosfomycin in VAP, UTI and sepsis, its efficacy, safety and susceptibility against resistant pathogen and drugs with which it can be used as combination therapy.
Sepsis is a medical emergency. Timely identification and taking the necessary steps is of utmost importance. Hence training and updating paramedics on sepsis plays important role since they are the primary care takers for their patients in hospitals.
The survival outcomes associated with addition of docetaxel to androgen deprivation therapy (Doc-ADT) were superior compared to maximum androgen-blockade (MAB) and ADT-alone in the treatment of patients with metastatic hormone-sensitive prostate cancer in China. Doc-ADT also was the most cost-effective treatment.
Newly diagnosed type 2 diabetes mellitus patients treated with an early combination therapy of vildagliptin plus metformin experience greater clinical and long-term glycemic durability benefits vs. those treated with standard-of-care initial metformin monotherapy or late combination therapy, according to the VERIFY trial.
According to the trial, prasugrel was associated with a greater reduction of composite of death, MI and stroke at one year without increased incidence of major bleeding events compared to ticagrelor in ACS patients for whom invasive evaluation was scheduled.
This retrospective cohort study assessed the effect pNPWT on the incidence of wound infections and other wound complications in patients undergoing elective open major CAWR. The study reported that use of pNPWT significantly reduced the rates of postoperative wound infections in the studied population.
This is first in vivo study employing a range of molecular and microscopy techniques to study the effect cadexomer iodine on microbial load of chronic non-healing diabetic foot ulcers (DFUs) complicated by biofilm. The study demonstrated that cadexomer iodine can reduce the microbial load and concomitant reductions in wound proteases in chronic DFUs complicated by biofilm.
Significant percentage of patients with severe allergic asthma (SAA) have blood eosinophil counts >300 cells/µl. The efficacy of omalizumab therapy is similar in high and low eosinophil subgroups.
Revolizer, a novel DPI, is preferred by more than 75% study population in India, states a recent study. Click Here to read more on ease‑of‑use, preference, confidence, and satisfaction with Revolizer, a novel dry powder inhaler, in an Indian population.
This article sheds light on the scenario of inhalation devices in India in terms of physician’s knowledge on inhaler devices, barriers faced while prescribing inhalers, selecting a particular inhaler device and training on inhaler devices.
A recent systematic review and meta-analysis from 95 publications revealed that more than three-fourths of adult patient population do not use PMDIs incorrectly. Click Here to read more on this study published by the COPD foundation.
Antifungals use in the ICU should be a different as compared to other wards. Suboptimal dosing of azoles is resulting in increase in resistance apart from treatment failure. ICU patient drug exposure may be influenced by altered drug distribution & clearance.
In this video, the speaker has discussed the important parameters, complications and their stepwise management in case of polytrauma.
In this video, the speaker has discussed the complications and algorithmic approach for managing periprosthetic joint infection.
Addition of enzalutamide to androgen deprivation therapy (ADT) significantly prolonged the overall survival and radiographic progression-free survival outcomes as compared to placebo plus ADT in patients with metastatic castration-sensitive prostate cancer. Treatment with apalutamide was safe and did not increase the incidence of adverse events as compared to placebo plus ADT.
Budesonide-formoterol used as needed was superior in preventing exacerbations in adults with mild asthma compared to as-needed albuterol.
In this video, the speaker has discussed the complications in managing femoral neck fracture and its solution.
According to the large-scale ELFIN trial, enteral bovine lactoferrin supplement did not reduce the risk of late onset infections in very preterm infants. The findings do not support the routine use of lactoferrin to reduce late onset infections in this population.
Currently, many doctors are still not giving the required loading doses of colistin for treating their patients due to nephrotoxicity concerns. This case based discussion is to help discuss the importance of given loading doses to the patients to manage their patients effectively and also talks about the issues with improper dosing.
This article provides details on various factors which influence the correct choice of inhaler device that will help improve patient adherence to treatment and increase the success of overall disease management.
Prevalence of small airways diseases in asthma patients is between 50 – 60%, including patients with normal FEV1, and patients with little or no proximal airflow obstruction.
Correct inhaler technique is important in achieving good clinical outcomes for patients with asthma and COPD. This article provides details on how to train patients effectively to overcome the errors committed and correct the inhaler technique.
Good inhaler technique is essential to maximize the benefits of inhaled medications and improve outcomes for the patient. This article provides guidance on how to optimize inhaler technique in patients by specifically focusing on the common errors reported.
Extra-fine Beclomethasone/Formoterol causes rapid bronchodilation and it is well tolerated in patients with asthma.
Extra-fine Beclomethasone/Formoterol combination is as efficacious as Budesonide/formoterol for treatment of asthma.
This is the first large study of eribulin use among real-world metastatic triple-negative breast cancer patients treated in the US. In this study, researchers observed no reduction in clinical benefits of eribulin therapy or changes in the safety or intolerability profile when used either early or late in the course of treatment.
Treatment with bilastine 20 mg was safe in elderly patients with allergic rhinoconjunctivitis and/or urticaria with a low incidence of treatment emergent adverse events (TEAEs). These findings were consistent with the safety profile of bilastine and incidence of AEs reported in previous studies and mentioned in the approved summary of product characteristics.
The combined intranasal formulation containing azelastine hydrochloride (AZE) and fluticasone propionate (FP) was superior to AZE in offering rapid and more complete symptom relief in patients with moderate to severe seasonal allergic rhinitis
The study demonstrates that a moderate weight loss (≥5%) in type-2 diabetes patients within a year of the disease diagnosis cuts down the risk of cardiovascular events over a period of 10 years.
With the launch of new GINA guideline 2019, management of asthma will witness complete paradigm shift.
Addition of enzalutamide to standard first line therapy significantly prolonged the overall survival, PSA progression-free survival (PFS) and clinical PFS at 3 years than the standard non-steroidal antiandrogen therapy in patients with metastatic hormone-sensitive prostate cancer. Treatment with enzalutamide was associated with a higher incidence of seizures and other toxic effects, especially in patients treated with early docetaxel.
Sun rays are harmful. Unprotected exposure to these rays can cause skin damage, eye damage, immune system suppression, and skin cancer. Here are a few tips to protect your skin from the harmful effects of sunlight.
Currently, many doctors are still not giving the required loading doses of colistin to their patients due to nephrotoxicity concerns. This case based discussion is to discuss the importance of giving loading doses to the patients to manage them effectively.
The EcLiPSE trial demonstrated no superiority of levetiracetam over phenytoin in any of the outcomes when used as second-line treatment for pediatric convulsive status epilepticus. Levetiracetam may be preferred over phenytoin due to its better safety profile and ease of administration.
Due to increase in the resistance pattern of the antibiotics it is found that there are challenges faced during Colistin testing. These challenges would be addressed in this webcast by the expert panellists.
Antibiotics are life-saving drugs, but unlike drugs used in other therapeutic areas, the future utility of many antibiotics is threatened by the emergence and spread of resistant bacteria. This presentation includes information about 4 R’s of using antibiotics responsibly.
About 5% of patients with cardiac arrhythmias or with heart failure are diagnosed with a ventricular tachycardia. Recurrent Ventricular Tachycardia may lead to sudden cardiac arrest. Mexiletine is approved in the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgement of the physician are life-threatening.
Multihaler is a discrete, multi dose dry power inhaler (DPI) with 6o doses. It has a dose indicator to indicate the number of doses remaining. It has the benefit of ease of use, portability and convenience of usage to the patient.
The study demonstrated moxifloxacin to be a better choice over gatifloxacin when used as a prophylactic measure during intraocular surgery. Gatifloxacin is more effective in case of refractive and extraocular surgeries.
This meta-analysis ascertained the impact of neonatal vitamin A supplementation on the mortality of infants aged 6-12 months. The findings were heterogeneous, with NVAS improving the survival in South Asia but not in Africa.
This study underscores the importance of breast feeding. Children who were breast fed for more than one month had a better IQ at five years of age, as compared to those who were breast fed for less than a month.
The present study analyses the rate of antibiotic prescriptions with Ibuprofen treatment for symptomatic treatment of uncomplicated UTI compared to fosfomycin. The study demonstrated that initial treatment with ibuprofen substantially reduced antibiotic use in women with mild to moderate symptoms of urinary tract infection.
The presentation includes description of synovial hyaluronic acid, its viscoelastic property, mechanism of action and different types available in market.
This presentation shows the structure of bone joint majorly affected in osteoarthritis, its pathophysiology, risk factors, signs and symptoms and management options.
This webcast provides an overview about burden of smoking / tobacco, it’s ill effect on health and treatment outcomes of many diseases associated with it. It also highlights application of Nicotine Replacement Therapy in India for quitting tobacco.
Treatment with bilastine 20 mg once daily for 2 weeks was effective and well tolerated by patients with perennial allergic rhinitis (PAR) and was associated with a rapid onset of action.
APPAC is a multicentre randomized trial comparing the long-term outcomes with antibiotics or surgical approach i.e. appendectomy in patients with uncomplicated acute appendicitis. The 5 –year follow-up data showed that antibiotic treatment demonstrated favourable outcomes compared to appendectomy suggesting it as a feasible and alternative option in the treatment of uncomplicated acute appendicitis.
The talk addresses the frequently asked questions in pediatric asthma practice by renowned speaker Dr Barnali Bhattacharya and Dr Sundeep Salvi. This event was done in coordination with CRF foundation.
Regular use of 1.8% self-prepared hypertonic nasal saline irrigation (1.8% SPHNSI) for 4 weeks is safe in patients with allergic rhinitis. 1.8% SPHNSI is more efficacious than 0.9% commercial isotonic nasal saline irrigation in improving the quality of life and reducing the nasal congestion
The SMART-DATE trial recommends that ACS patients undergoing PCI with DES be treated with prolonged DAPT (at least 12 months) rather than short-term DAPT (6 months) as the latter was associated with a significantly high risk of myocardial infarction.
Mometasone furoate (MF) implants were beneficial in the management of chronic rhinosinusitis patients with recurrent nasal polyps. MF implants resulted in significant improvements over a range of subjective and objective endpoints and reduced the need of repeat surgery by 61%.
Long-term treatment with riociguat had a favorable benefit-risk profile in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) or persistent CTEPH after pulmonary endarterectomy. Improvements in exercise and functional capacity and hemodynamic parameters were sustained for upto 1 year.
The beclomethasone dipropionate (BDP)/formoterol extrafine formulation was efficiently delivered to the lungs and resulted in high drug deposition and homogenous distribution of BDP and formoterol throughout the airways, irrespective of the pathophysiology and lung function.
The study reveals bilastine to be clinically beneficial in patients with Japanese Cedar (JC) pollinosis. Bilastine had a rapid onset, and long duration of action against nasal symptoms induced by the 3-day consecutive exposure to JC pollen in the OHIO Chamber.
ALTERNATIVE Trial is the first large randomized trial that evaluated dual HER2 blockade plus an aromatase inhibitor for HER2-positive/HR-positive metastatic breast cancer postmenopausal women who received prior endocrine therapy and prior neo (adjuvant)/first-line trastuzumab plus chemotherapy. The study showed that this combination offers an effective and safe chemotherapy-sparing alternative treatment regimen for this patient population.
The study demonstrated that early administration of caffeine in preterm infants with a gestational age of <29 weeks was associated with improved neurodevelopmental outcomes at 18-24 months.
The 2019 GINA strategy report represents the most significant change in asthma management in over 30 years. The 2019 GINA report includes important new recommendations for treatment of mild asthma and severe asthma.
This was a 144-week analysis comparing the efficacy and safety of TAF vs TDF, each co-formulated with elvitegravir, cobicistat, and emtricitabine (e/c/f) for initial HIV-1 treatment. The 3-year results showed that TAF was superior to TDF in efficacy, renal and bone safety.
This study confirms the ubiquitous prevalence of rhinitis in urban pediatric asthma patients while exploring the phenotypes and characteristics of rhinitis.
In this video, the speaker gives an overview of the common conditions and reasons of medico-legal concerns for orthopaedicians, with focus on preventive measures to be taken for minimizing the same.
Age-related Macular Degeneration (AMD) is a common eye condition and a leading cause of vision loss among people age 50 and older. This patient education leaflet on AMD gives a brief description of the disease and answers basic questions faced by a AMD patient.
Diabetic retinopathy (DR) is the most common and most serious of the ocular complications of diabetes mellitus. This patient education leaflet on DR gives a brief description of the disease and answers basic questions faced by a DR patient.
Findings of the study showed that SGLT2 inhibitors effectively reduce the risk of MACE, renal outcomes, and hospitalizations for HF in T2DM patients. Their use in T2DM patients must therefore be considered irrespective of the presence of ASCVD or HF history.
Ramadan fasting not only alters the timings of meals, but it may also disturb sleeping patterns and biological rhythms, all of which can affect a person’s metabolic state. As patients’ dietary and exercise timings change during this month of Ramadan, insulin dosage may need to be altered. This infographic shares concise information on insulin dosage & timing alteration as per IDF-DAR guidelines on Diabetes & Ramadan.
Long-term administration of midodrine along with standard medical therapy improves the systemic hemodynamics without any renal or hepatic dysfunction and results in a better control of ascites in nonazotemic cirrhotic patients with refractory or recurrent ascites.
Ramadan fasting not only alters the timings of meals, but it may also disturb sleeping patterns and biological rhythms, all of which can affect a person’s metabolic state. As patients exercise and dietary timings change during this month of Ramadan, some drugs may need to be altered or their dose needs to be reduced. This infographic shares concise information on drug alteration timing & dosage as per IDF-DAR guideline on Diabetes & Ramadan.
This is the first prospective phase 2 trial assessing a combination of chemotherapy and targeted therapy in patients with previously untreated brain metastases from HER2- positive breast cancer. The findings reported in this study suggest that the combination of lapatinib plus capecitabine is active for the treatment of brain metastases in patients with HER2-positive breast cancer.
The combined intranasal formulation containing azelastine hydrochloride and fluticasone propionate was safe and well tolerated after 3 months continuous use in children aged 4 to 11 years with allergic rhinitis (AR)
This study presents the risk factors for the development of the brain metastases for early and advanced (metastatic) HER2+breast cancer, local treatment approaches and outcomes of patients with brain metastases. The study identified risk factors associated with the development of brain metastases in HER2+ breast cancer patients.
This study gives a fair picture of the prevalence of dry eye disease and their types in India. The study also determines various risk factors associated with the disease.
Fasting & feasting during Ramadan in diabetes patients is associated with altered glucose level which may lead to low or high blood sugar level. This leaflet gives information on warning signs for high & low blood glucose level. Certain Do’s & Don’ts during Ramadan fasting help to manage diabetes more effectively & safely.
Treatment with riociguat demonstrated improvement in 6-minute walk distance, pulmonary vascular resistance, WHO functional class and other clinical outcomes in patients with chronic thromboembolic pulmonary hypertension
The formulation with L-carnitine (LC) and its active form L-acetylcarnitine exerted beneficial effects on the sperm motility, vitality and DNA fragmentation in men with idiopathic oligoasthenozoospermia. Seminal LC concentrations play a vital role in maintaining the male fertility. Combining metabolic and micronutritive factors is beneficial for male infertility.
The VERDICT trial compared the long-term clinical outcomes following an early invasive coronary evaluation strategy vs. the standard invasive coronary evaluation strategy in patients with clinically suspected acute coronary syndrome. Early invasive strategy did not improve overall long-term clinical outcomes vs. standard invasive strategy.
GeparQuinto trial is phase 3 study comparing lapatinib versus trastuzumab in combination with chemotherapy for treatment of HER2-positive primary breast cancer. The 3-year’s results report a lower pathological complete response with lapatinib than trastuzumab and no effect on long term outcomes.
Prevalence of atypical femoral fractures (AFF) induced by long-term treatment with bisphosphonates, ranges between 3.22 and 113.1 cases per 100,000 patients. This is the first study to report of mesenchymal stromal cells functionality improvement in osteoporotic women treated with teriparatide, after AFF. Teriparatide administered subcutaneously every day for 6 months improved functionality and regenerative capacity of mesenchymal stromal cells (MSC), thereby improving the bone health in these patients.
The study demonstrated a significantly greater improvement in plasma renin activity and eGFR with oral midodrine vs. octreotide in cirrhosis patients with ascites.
Fasting & feasting during Ramadan in diabetes patients is associated with increased risk of complications such as hypoglycemia, hyperglycemia, ketoacidosis etc. Pre-Ramadan patient risk assessment & structured counselling helps to manage diabetes in patients who observe fast during Ramadan. This presentation focuses on key components of Ramadan focused educational program, risk stratification, dietary & exercise advise, pharmacological management & post-Ramadan follow-up.
Upfront combination therapy with macitentan and riociguat demonstrated improvement in exercise capacity, functional class, degree of dyspnea on exertion, right ventricular function biomarkers and hemodynamic variables in patients with pulmonary arterial hypertension. A low risk status was attained at 4 months and maintained at 12 months by approximately 50% patients, without the addition of a third drug.
Fluticasone propionate is a potent inhaled corticosteroid with high lipophilicity, greater retention at the steroid receptors and negligible oral bioavailability compared to budesonide. It is more effective even at half the dose of budesonide. For more details click on the link for datasheet.
The present study evaluated the efficacy and safety of oral ciprofloxacin in the management of external bacterial otitis. The 10-day treatment with ciprofloxacin demonstrated clinical and microbiological efficacy with minimum adverse events.
This novel study demonstrates better and sustained improvement in work productivity outcomes in relapse-remitting multiple sclerosis patients treated with dimethyl fumarate vs. those treated with β-interferon or glatiramer acetate.
The study demonstrated six months of DAPT to be non-superior to 12 months of DAPT in STEMI patients who remain event free after primary PCI with second generation drug eluting stents.
PROMISE is the largest study of antimicrobials performed in complicated intra-abdominal infections (cIAIs) patients. The study compared the clinical and bacteriological efficacy and safety of moxifloxacin versus ertapenem for the treatment of cIAIs. The findings showed that moxifloxacin was non-inferior to ertapenem in terms of clinical and bacteriological efficacy in treatment of cIAIs.
Treatment with vibegron was associated with reduction in the frequency of nocturnal voiding, increase in the volume per nocturnal void and volume of first nocturnal voiding in overactive bladder (OAB) patients with >1 voids. The extension of HUS led to improved quality of sleep. Vibegron could be a useful therapeutic option for improving the nocturia in OAB patients
In this eCME, Prof Hania gives the global perspective about usage of probiotics in paediatrics. The talk ill also covers the Indian perspective from renowned clinicians. It also throws some light on newer trends in management of diarrhea with a comprehensive treatment option of ORS + Zn + Probiotics.
The SWISH trial investigated the prophylactic use of dexamethasone-based mouthwash for stomatitis in women receiving everolimus and exemestane for hormone receptor positive breast cancer. The 8-week results showed that dexamethasone mouthwash was effective in the prevention of or reduction in the incidence and severity of all-grade stomatitis.
Smoking cessation is the most important intervention in management of COPD. This article details the importance of smoking cessation, and therapeutic options available for smoking cessation.
This article deals with multidisciplinary approach to pulmonary rehabilitation which is essential to achieve optimal results. Detailed information is presented on the diverse program components in pulmonary rehabilitation and will serve as a useful guide for the clinicians.
The study demonstrated that dimethyl fumarate is superior to teriflunomide in reducing the annual relapse rate and risk of relapse in multiple sclerosis patients switching from injectable platform disease modifying treatments to orals.
This large-scale study reaffirms albuminuria to be an independent marker of subsequent all-cause mortality and cardiovascular events in insulin-treated type-2 diabetes mellitus (T2DM) patients. Reducing albuminuria to achieve optimal CV protection should be an important target for high-risk T2DM patients.
The OSTRICH trial found no benefits of short course of oral steroids over placebo for treating persistent otitis media with effusion in children.
This booklet is intended to provide physicians with all the essential information on inhaler devices.
A systematic review and meta-analysis concluded that intravesical instillation of onabotulinum toxin-A (OBTX-A) had limited efficacy with improvement of voided volume in the treatment of overactive bladder or interstitial cystitis/bladder pain syndrome. More studies are warranted to assess the efficacy of intravesical instillation with OBTX-A in patients refractory to medication therapy and to investigate the effective drug transport.
In this video, Dr Reddy discusses use of teriparatide in India, its approved & off-label indications, short & long-term side effects, precautions, it’s combination and sequential therapy.
This booklet aims to update clinicians with the developments in the diagnosis and management of severe asthma.
It has been 25 years since the inception of tiotropium and it has been 15 years in clinical practice. Tiotropium has now established itself as a trustworthy and recommended choice in COPD maintenance therapy. This booklet takes you through the journey of tiotropium in all these years.
Early use of vacuum therapy significantly improved the erectile dysfunction and penile shrinkage in men post radical prostatectomy (RP) and enhanced the advantages of penile rehabilitation when used along with PDE-5i. Overall, vacuum therapy resulted in an overall excellent therapeutic effect with no serious adverse events.
This booklet is intended to provide physicians with all the essential information on spacer devices.
Pulmonary arterial hypertension (PAH) and Chronic thromboembolic pulmonary hypertension (CTEPH) are rare, progressive pulmonary vascular disease with poor outcome, if left untreated. Inadequate signaling of the NO-cGMP pathway may play an important role in the pathogenesis. Riociguat, a stimulator of soluble guanylate cyclase, has been globally approved for the treatment of PAH and inoperable CTEPH and persistent/recurrent PH after pulmonary endarterectomy. Findings from the phase III CHEST and PATENT studies indicate that riociguat significantly improves exercise capacity and a range of secondary end points, including pulmonary hemodynamics, NT-proBNP levels, and WHO FC, in patients with inoperable CTEPH and persistent/recurrent CTEPH and in PAH.
Among the PAH therapies, endothelin receptor antagonists (ERA) have shown efficacy in the treatment of PAH due to their vasodilatory and anti-hyperplastic effects in the pulmonary arterial vasculature. Macitentan is not only potent but also a safe and well tolerated newer ERA, proven to reduce morbidity and mortality related to PAH. This monograph provides an overview of the challenges in PAH management and the place of macitentan in the treatment algorithm.
Orthostatic Hypotension is common in elderly (>70 years of age) and can also occur secondary to neuropathy like in diabetes or central lesions like Parkinson’s disease. Midodrine has been approved in the pharmacologic management of symptomatic orthostatic hypotension.
This survey of doctors in Myanmar revealed that spirometry and peak flow meter use could be increased. Budesonide, Salmeterol/fluticasone, formoterol/budesonide and Salbutamol are the most preferred molecules. Awareness about inhalers and inhalation therapy are important to overcome apprehension in patients’ minds. Regular and repeated device training can improve adherence and asthma control.
A recent prospective study concluded that the extended lymph node dissection (LND) in bladder cancer patients undergoing radical cystectomy did not show any significant benefits over limited LND in terms of recurrence free survival, cancer specific survival and overall survival. There were survival differences between the groups but they were statistically insignificant.
The TRANSITION study indicates early initiation of sacubitril/valsartan pre-discharge in acute HFrEF patients is a feasible and safe option.
The extended analysis of DEFINE trial demonstrates the favorable impact of delayed release DMF on various MRI parameters for up to 2 years.
This survey of doctors in Nepal revealed that spirometry and peak flow meter use could be increased. Budesonide, Salmeterol/fluticasone, formoterol/budesonide and Salbutamol are the most preferred molecules. pMDIs and spacers are very popular. Adherence is low and remains a challenge.
The PIONEER-HF trial ascertains the impact of sacubitril-valsartan therapy in hemodynamically stable patients hospitalized for acute decompensated HF.
This study determined the incidence of adverse drug reactions (ADRs) and factors associated with the safety and efficacy of adalimumab in Japanese rheumatoid arthritis patients. The 3-year results of this postmarketing surveillance of adalimumab in the treatment in RA patients support the known safety profile of adalimumab with no additional safety signals.
This trial compares the safety and efficacy of TAF vs TDF co-formulated with elvitegravir, cobicistat, and emtricitabine, for initial treatment of HIV-1 infection. The 48-week results show the favourable safety profile of TAF compared TDF.
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) report 2018 has recently been updated. This article summarises the key changes.
This slide set covers basic understanding of probiotics and mechanism of action focussing on Lactobacillus rhamnosus GG strain.
Asthma is heterogeneous disease characterized by airway hyperresponsiveness, bronchoconstriction and inflammation with variable airflow limitation. The clinical presentation and phenotypic characteristics of cough variant asthma, nocturnal asthma and exercise induced asthma is elucidated along with their diagnosis and treatment approach.
Oral dimethyl fumarate is a potential initial treatment for relapsing-remitting multiple sclerosis, as per the findings of the CONFIRM trial.
This booklet is a compilation of severe asthma registries, real world studies and evidences on the long term usage, safety and efficacy of Omalizumab in severe persistent asthma both in pediatric and elderly population.
The current treatment paradigm of asthma has been steered in the direction of tailored management. This booklet focuses on the identification, management and advances in Severe Asthma.
Treatment for chronic constipation has evolved with the advent of newer targeted therapies. Prucalopride is the first, selective and specific serotonin 5-HT4 receptor agonist with enterokinetic properties. In view of its excellent affinity for 5-HT4 receptors devoid of the cardiac adverse effects seen with other prokinetics, prucalopride provides an effective alternative for patients who fail previous laxative treatment. This slide set gives an overview of the mechanism, efficacy, safety and place in therapy for prucalopride.
Riociguat, a stimulator of soluble guanylate cyclase, has been globally approved for the treatment of PAH and inoperable CTEPH and persistent/recurrent PH after pulmonary endarterectomy. Findings from the phase III CHEST and PATENT studies indicate that riociguat significantly improves exercise capacity and a range of secondary end points, including pulmonary hemodynamics, NT-proBNP levels, and WHO FC, in patients with inoperable CTEPH and persistent/recurrent CTEPH and in PAH.
This CME details the newer concepts in the treatment of bronchiectasis.
This CME shares role of nebulized antibiotics in current and future perspectives.
This CME shares the case based discussion on immune-deficient bronchiectasis.
This CME shares the case based discussion on surgery in bronchiectasis
In this cme NTM Bronchiectasis cases are discussed.
In this cme ABPA Bronchiectasis cases are discussed.
Most of the times bronchiectasis gets overlapped with COPD. This CME shares the details of treatment of Bronchiectasis and COPD – Bronchiectasis overlap.
This CME shares the details of treatment of Bronchiectasis and non-pharmacological management of bronchiectasis.
This CME shares the details of bronchiectasis treatment and management of exacerbation.
Prevalence data on Bronchiectasis is not clear. This cme share the details of EMBARC registry conducted on European patients.
Prevalence data on Bronchiectasis is not clear. This cme shares the details of EMBARC registry conducted on Indian patients.
Bronchiectasis often leads to bacterial contamination. This cme details microbiological aspects of bronchiectasis.
Diagnosis of bronchiectasis is a challenge amongst clinicians as the symptoms overlap with COPD and Asthma. This cme share various criterias and parameters to diagnose Bronchiectasis.
This cme shares the brief overview on bronchiectasis on prevalence , diagnosis and management
In today’s scenario, our most of the Critical Care physicians are faced by challenges – managing ARDS in the available healthcare set ups. Cipla being The Leader in Critical Care Business has partnered with ISCCM to address such challenges through a digital platform to reach maximum hospitals.
This 52 –week trial presents the efficacy and safety results of budesonide-formoterol used as needed in comparison with short-acting β2-agonists (SABAs) terbutaline used as needed or budesonide maintenance therapy in mild asthmatic patients. The results showed that budesonide – formoterol demonstrated superior asthma symptom control and asthma exacerbations risk reduction compared to terbutaline used as needed in patients with mild asthma.
The SYGMA-2 trial demonstrated the non-inferiority of as-needed budesonide-formoterol vs. maintenance budesonide in patients with mild asthma.
Treatment with dienogest 2 mg daily over a period of 60 months was significantly effective in reducing endometriosis-associated pelvic pain and recurrence of pain after surgery. Dienogest was well tolerated and the adverse effects could be managed.
Bacillus Calmette Guerin (BCG) therapy reduced the rate of recurrence in patients at high risk non-muscle invasive bladder cancer (NMIBC), irrespective of grade and stage of tumors and significantly reduced progression in papillary tumors without concomitant carcinoma in situ. The long-term effect of BCG treatment makes it suitable as the first line adjuvant treatment in patients with high risk NMIBC.
Invasive fungal infections (IFIs) are a significant cause of morbidity and mortality for immunocompromised patients. Unfortunately, the clinical usefulness of many antifungal agents is limited by safety and tolerability. Posaconazole is a relatively safe and well-tolerated broad-spectrum azole antifungal agent. Newer posaconazole formulations, oral tablet and intravenous, increase its availability to a larger patient population.
Neonatal caffeine therapy safely treats apnea of prematurity in very low birth weight neonates without any adverse long-term neurobehavioral outcomes.
Low power Holmium laser enucleation of the prostate (HoLEP) was non-inferior to high power HoLEP with respect to all operative efficiency parameters, irrespective of the level of experience of the surgeons. The efficiency outcomes of HoLEP was maintained across the different follow up points irrespective of the laser power used.
Treatment with sacubitril/valsartan improves physical and social limitations in HFrEF patients in addition to the CV benefits that it provides.
A recent survey determined that there was a high burden of COPD among females as-well-as non-smokers in Nepal. Doctors in Nepal were following GOLD recommendations for the treatment of COPD. DPI was the most preferred device, nevertheless, in the patients who used pMDI, the use of spacer can be increased. Evaluation of inhalation technique in every visit can improve the adherence level among COPD patients.
The study analyzes renal effects and the associated outcomes of sacubitril/valsartan vs. enalapril in HF patients with reduced ejection fraction.
ABILITY-3 study is a randomized controlled trial evaluating the safety and efficacy of continuing versus withdrawing adalimumab therapy in patients with active non-radiographic axial spondyloarthritis. The results showed that continued adalimumab therapy was associated with higher rate of maintenance of remission compared to treatment withdrawal.
The article consists of basic information on Parkinson’s disease, its common features, management and tips to cope with the disease.
Urinary Tract Infection (UTI) is common in children, and timely diagnosis is crucial. It takes a set of skill to properly identify not only symptoms but also the probable complications if not treated properly. In this webcast, Dr. Kanav Anand, a pediatric nephrologist shares his expert views on investigating UTI in children.
This slide set contains basic understanding of common mental health problems in old age, early warning signs and tips for better mental health care.
This slide set discusses the issue of substance abuse in India with the risk factors, common reasons, early signs, and treatment of substance abuse.
This slide set contains general understanding of principal features, risk factors, and treatment for ADHD in children and adults.
This slide set discusses the importance of mental health, factors contributing to mental health issues, and ways to maintain positive mental health.
Hospital acquired infections due to MDR gram-negative bacteria constitute major health problems. The healthcare community is continuously running out of available effective antibiotics and no new agents are in the pipeline.
Polymyxins represent one of the last treatment options for MDR Gram-negative infections. Both Polymixin B and E exhibit similar chemical structure and in-vitro antibacterial activity but there are certain key differences amongst them.
Hence, to debate and deliberate on pros and cons of each molecule, this is an enlightening Rebuttal Webcast on “Peas in a Pod, or Chalk and Cheese”. These evidence based discussions will aid in defining place in therapy of these molecules.
In this eCME, the speaker gives an overview of various benefits of combined oral contraceptive pills, beyond contraception.
In this eCME, the speaker gives an overview of various hormone therapies available during menopause (MHT), potential candidates who can be prescribed MHT, their risks and benefits with elaborate case-based discussions.
This survey of doctors in Malaysia revealed that spirometry and peak flow meter use could be increased. Budesonide, Salmeterol/fluticasone, formoterol/budesonide and Salbutamol are the most preferred molecules. pMDIs and spacers are very popular. Adherence is low and remains a challenge.
This survey of doctors in Malaysia revealed that they followed GOLD recommendations for COPD management. pMDI with or without spacer was the most preferred treatment choice for COPD. Adherence can possibly be increased by demonstration of inhalation technique during visits.
The ATLAS study demonstrated low-dose amisulpride (100 mg/day) to be an effective strategy for the treatment of late-onset schizophrenia-like psychosis.
In this video, Dr Vetrivel has expressed his opinions about single handed endoscopic ear surgery and the benefits associated with the same.
An Indian study demonstrates persistent reduction in risk of T2DM even 3 years after withdrawal of active SMS-based lifestyle intervention.
Polymyxins have been associated with a risk of nephrotoxicity. Different studies have evaluated the toxicity of polymyxins and have demonstrated a wide variation in the rates of nephrotoxicity. However, there are no prospective studies which have compared the nephrotoxicity of colistin and polymyxin B when they are administered in high doses and as per current recommendations
In this video, Dr. Ashok Mahashur addresses various questions governing the use of maintenance nebulization therapy as an effective option in management of COPD.
Treatment with macitentan 10 mg resulted in significant reduction in the risk and rate of all-cause hospitalization in patients with pulmonary arterial hypertension. Macitentan 10 mg also significantly reduced the duration of hospital stay. The risk and rate of PAH-related hospitalization was also reduced significantly in the patients treated with macitentan.
Comparing budesonide/formoterol combination vs. fluticasone/salmeterol to prevent exacerbations and various healthcare-related outcomes in COPD patients
The prospective, community-based 26-year follow-up study looks at the impact of diabetes on kidney function decline in a general population.
This combined analysis of SOFT and TEXT trials showed that after a median follow-up of more than 8 years addition of ovarian suppression to tamoxifen resulted in significantly higher rates of disease-free survival. Additionally, further improvement was seen with exemestane plus ovarian suppression among premenopausal breast cancer patients.
This is the first large contemporary analysis of real-world clinical practice that compared the risk of cardiovascular events among hip fracture patients with or without antiosteoporosis treatment. The findings showed that use of alendronate was associated with a reduced risk of cardiovascular mortality, MI, and stroke.
The study concluded that the efficacy of dienogest 2 mg daily for 12 weeks was superior to placebo in reducing the endometriosis-associated pelvic pain. Treatment with dienogest was associated with a good safety and tolerability profile.
Results of the SERAPHIN study demonstrated that treatment with macitentan resulted in significant reduction in morbidity and mortality in patients with pulmonary arterial hypertension.
The TITRATION trial assessed tolerability of initiating/uptitrating sacubitril/valsartan using a conservative or condensed regimen in HFrEF patients.
This randomized controlled trial compared the analgesic effect and safety of the three different methods of postoperative analgesia in patients undergoing hepatectomy. The trial provides clinical insights into the application of local incision analgesia.
The inhaled route of drug delivery is the mainstay for treating chronic respiratory diseases like asthma and chronic obstructive pulmonary disease (COPD). No matter how good a drug is, it is ineffective if it does not reach the targeted area in lungs. Incorrect inhaler use in patients with asthma and COPD is unacceptably high in real-life. Though a lot has been done in the space of newer drug molecules, over the years there is little change in the drug delivery platforms. Problems with the use of inhalers by patients were noted shortly after the launch of the pressurized metered dose inhalers (pMDIs) in the late 1950s and prevail till date.
As a part of its ongoing commitment to inculcate excellence in the practice of respiratory medicine, Cipla introduces Synchrobreathe, world’s first breath actuated pMDI with dose counter. Synchrobreathe® is a well-researched device and backed by evidence that establishes its superiority over pMDIs to help patients achieve better control of their airway disease.
This document gives the revised recommended dosages of misoprostol when used alone, for a variety of gynaecologic and obstetric indications. The recommendations were release by FIGO in 2017.
This non-inferiority trial demonstrated comparable efficacy of dienogest 2 mg daily to leuprolide acetate depot in reducing the endometriosis-associated pelvic pain. Treatment with dienogest was associated with a better safety and tolerability profile as compared to LA with lower incidence of hot flushes and minimal changes in the BMD and bone metabolism.
This presentation includes information pertaining to the molecule Luliconazole, which is a novel topical imidazole antifungal agent used for the treatment of superficial fungal infections.
Nicotine Chewing Gum offers a nicotine that enables quitting with the principle of Nicotine Replacement Therapy (NRT). Nicotine Chewing Gum provides the nicotine that you normally get from cigarettes but in a lower quantity than cigarettes. Over a period of time, your body adjusts to the reduced supply of nicotine until you no longer need any. A 12-week therapy programme using Nicotine Chewing Gum will help you get back to life without dependence on nicotine.
Dienogest is an oral progestin with unique pharmacological properties, and is indicated at a dosage of 2 mg/day for the management of pelvic pain associated with endometriosis. These slides give an overview of its pharmacology, efficacy / safety and advantages over options available for medical management of endometriosis.
Endometriosis is the presence of endometrial tissue outside the uterine cavity and has a burden of around 176 million women globally. These slides give an overview of the symptoms, associated complications, diagnosis and medical management options available for endometriosis.
Combination of Abiraterone with ADT is highly efficacious in treating men with metastatic castration-sensitive prostate cancer with manageable adverse effects. LATITUDE trial establishes a new indication for abiraterone (metastatic castration-sensitive prostate cancer), filling in a therapy need as a less toxic alternative to chemotherapy.
The results of the study revealed that long-term or cumulative PPI use was not associated with an increased risk of hip fracture in community-dwelling older persons with Alzheimer’s disease. Additionally, current PPI use increased the risk of hip fracture. The risk was elevated in subjects currently using PPIs for less than 1 year.
LIBERATE trial assessed the efficacy and safety of apremilast vs. placebo in biologic-naive patients with moderate-to-severe plaque psoriasis and safety of switching from etanercept to apremilast. The 52-week analysis of this study showed that oral apremilast is a safe and effective treatment for biologic-naive patients with moderate-to-severe plaque psoriasis.
Macitentan is an orally active, potent, tissue targeting ERA that is indicated for the treatment of pulmonary arterial hypertension (PAH). It is the first proven ERA therapy to show reduction in morbidity and mortality in patients diagnosed with PAH. This presentation covers the pharmacology and key studies of macitentan.
This study assessed the effectiveness and tolerability of erlotinib in elderly patients with non-small-cell lung cancer (NSCLC) after ≥1 platinum-based chemotherapy. The study concluded that erlotinib represents a suitable palliative treatment option in further therapy lines for elderly patients.
This trial evaluated the influence of Target workshops on antibiotic prescription and antibiotic use among healthcare providers. The study found TARGET antibiotic workshops may improve antibiotic use.
Long-term but not short-term maternal use of acetaminophen during pregnancy significantly increases the risk of ADHD in offspring, as per this study.
Parenteral macrolide therapy is needed for patients with moderate to severe CAP/AECB. This booklet gives an overview of the efficacy and safety of intravenous clarithromycin, its place in therapy of LRTIs and its advantages over other macrolides.
Gastroparesis or Gastrointestinal dysmotility has been shown to have an almost 40-50% overlap with GERD, thus it ends up worsening the symptoms of GERD. Besides the most commonly listed causes of gastroparesis are idiopathic and diabetic. In this webcast, Dr Manu Tandon from AIG Hyderabad has shed light on the many more other causes of gastroparesis and the promising management options for the same.
As per this study, selectively created non-randomized real-world data might be valuable in establishing supplemental drug indications of medication.
This article discusses the clinical outcomes using modified dosage regimes of clomiphene citrate for ovulation induction.
Cessation of nucleos(t)ide analogue therapy in Caucasian patients after HBeAg seroconversion was associated with high relapse rates in more than 50% of the patients with fatal outcomes. Gamma-GT levels at the initiation of treatment and at HBeAg seroconversion were significant predictors of clinical relapse. This real world study suggested continuation of NA therapy after HBeAg seroconversion until HBsAg loss.
The study stated that patients at risk for Barrett’s Esophagus could be effectively screened by combining the swallowable balloon device and molecular assays of CCNA1 and VIM DNA methylation. This non-endoscopic detection of BE with DNA methylation biomarkers was well-tolerated and could screen the patients with high sensitivity and specificity.
The new Multi-haler™ is an advanced discrete Multidose dry powder inhalers (mDPIs) with an in-built dose counter containing 60 pre-loaded doses and is designed to hold additional grooves for optimum evacuation of drug-formulation. This article reports the findings of Salmeterol/Fluticasone Propionate-50mcg/250mcg (SFC-250) Multi-haler™ (60-doses) evaluated for its design and in-vitro performance.
The new Multi-haler™ is an advanced discrete multidose-DPI (mDPI) developed to match the performance of an established mDPI, Accuhaler. The study aimed to evaluate in-vitro lung deposition and device resistance of Salmeterol/Fluticasone Propionate-50mcg/250mcg (SFC-250) combination in Test-mDPI (Seroflo 250 Multi-haler™, Cipla Ltd) and Reference-mDPI (Seretide 250 Accuhaler™, Glaxo Smithkline Pharmaceuticals Ltd.).
Inhalation therapy is the main route of drug administration in patients with asthma and Chronic Obstructive Pulmonary Disease (COPD). Inhaled drug delivery systems are available in four principal categories: pressurized metered-dose inhalers (pMDIs), dry powder inhalers (DPIs), breath actuated inhalers (BAIs) and nebulizers; each class with its unique strengths and weaknesses. This booklet focuses on information that builds on principles of DPIs and its application.
Metformin is superior to intermittent IIT for preservation of beta-cell function and better glycemic control in early Type-2 diabetes patients.
The FIX-IT study showed a greater skeletal healing with immediate teriparatide than delayed in patients with atypical femoral fracture.
In CREATE -X trial, adjuvant capecitabine therapy demonstrated prolonged disease-free survival and overall survival in breast cancer patients.
The use of proton pump inhibitors (PPIs), irrespective of the dose, taken with or without diuretics, did not lower the levels of serum magnesium in non-critically ill patients.
There was no significant reduction in the rate of perinatal transmission of HBV with the maternal use of tenofovir disoproxil fumarate (TDF).
This slide set covers the basics of pathophysiology and treatment for functional dyspepsia, which is defined as per the Rome III criteria.
This is the longest 40-year follow-up trial of tamoxifen in high –risk breast cancer patients, exhibiting a sustained reduction in mortality.
This tool gives specific directions to treat patients with chronic hepatitis B. Insights of 5 experts are present in this interactive tool to help guide you through the appropriate management approach.
The CARDIA study with a 30-year follow-up demonstrated an inverse association between lactation duration and progression of diabetes in women.
Meta-analysis of 9 trials indicates that prasugrel is equivalent or superior to ticagrelor in ACS patients undergoing PCI.
Cough is one of the most common symptoms that doctors encounter during their clinical practice. In this video, Dr Sundeep Salvi demonstrates various types of cough. Listening carefully to the cough sound can help in identifying the location of the pathology and diagnosing the respiratory disease.
The booklet addresses common queries on the role of intranasal steroids (INCS) in management of allergic rhinitis.
Midazolam nasal spray is equally effective but more preferred than diazepam rectal solution in adult patients with epilepsy and seizure exacerbations.
Visual discomfort is a frequent complaint of computer workers. Eyestrain, headaches and blurred vision are the most common problems reported. This video addresses ways to optimize your computer workstation to reduce the specific risks of computer vision syndrome (CVS).
Stress is a common problem in everyday life. The slide set discusses about signs and symptoms of stress, effective stress management strategies, and work-life balance.
In this long-term study, alendronate 10 mg treatment for over 10 years demonstrated sustained clinical efficacy and safety in postmenopausal women with osteoporosis.
Today, antiretroviral therapy (ART) is not only known to keep HIV-infected patients alive but is also being harnessed as a strategy to prevent further transmission of the virus. This issue of the HIV Management Series (HMS) provides a broad overview of the key antiretroviral-based HIV prevention strategies.
Systemic Lupus Erythematosus (SLE) is an inflammatory disease caused when the immune system attacks body’s own tissues. This leaflet gives an overview of SLE, its symptoms, causes, complications and treatment.
Eating foods rich in calcium and vitamin D may help prevent bones from becoming weak and less likely to fracture. This article gives a list of food items rich in calcium and Vitamin D.
Calcium and vitamin D are two essential nutrients long known for their roles in maintaining bone health. This article gives comprehensive recommended dietary allowances for calcium and Vitamin D.
The slide set encompasses basic understanding of depression and its symptoms, treatment and support, common myths and facts, and healthy lifestyle tips.
This study demonstrated that shortening the treatment duration during initial therapy for drug-sensitive tuberculosis can be achieved with gatifloxacin and moxifloxacin.
The analysis of three Phase III trials was conducted to assess the efficacy and safety of the recently introduced pangenotypic sofosbuvir-velpatasvir fixed dose combination across the Hepatitis C genotypes 1, 2, 3, 4, 5 and 6. The fixed dose combination was found to be highly effective, safe and well tolerated by the treatment-naïve as well as treatment experienced patients. The sustained virologic response at 12 weeks remained unaffected in previously treated and untreated patients including those with uncompensated cirrhosis.
Combination therapy of vildagliptin/metformin demonstrated consistent HbA1c reduction across wide spectrum of drug naïve Asian T2DM patients.
This presentation discusses various pros and cons of minimally invasive procedures over open urological surgeries.
This presentation discusses various prostate cancer cases and approaches to their management.
This presentation discusses management options for various BPH cases.
The current webcast provides an insight on the most common vitreo-retinal diseases like diabetic retinopathy, macular degeneration, retinal detachments or tears, macular holes, retinopathy of prematurity, retinoblastoma, uveitis, eye cancer, flashes and floaters and retinitis pigmentosa.
This presentation provides an overview on PCNL-Papillary Vs non papillary puncture, RIRS- current concepts.
This presentation provides an overview on recent advances in ESWL in management of urolithiasis.
The present analysis evaluated the efficacy and safety of sacubitril/over enalapril in HF patients across different levels of SBP.
Celiac disease is one of the most prevalent digestive conditions. Diagnosis requires strict criteria with a life-long gluten-free diet that needs to be correctly prescribed. Genetic susceptibility an important contributory factor in response to unknown environmental factors leading to development of an immune response that is subsequently triggered by the ingestion of gluten. The disease has many clinical manifestations, ranging from severe malabsorption to minimally symptomatic or non-symptomatic presentations. This slide set covers the pathogenesis, diagnosis and management of celiac disease.
This Indian study showed efficacy and safety of a novel bone formation agent, teriparatide in osteoporotic women and suggested that it is an ideal therapeutic option for treating osteoporosis.
The ERS 2017 conference proceedings give an overview of the latest updates in the field of ENT.
The present study is a critical appraisal of the existing evidence on the benefits and harms of sacubitril/valsartan in patients with HFrEF.
The ERS 2017 conference proceedings gives an overview of the latest updates in the field of respiratory medicine; especially recent research in asthma, chronic obstructive pulmonary disease, allergic rhinitis, infections and lung cancer; as well as obstructive sleep apnoea.
Pomalidomide-dexamethasone is a standard of care in patients with relapsed/refractory multiple myeloma following exhaustion of treatment options.
The real-world study concluded that twice daily Fluticasone/Formoterol administered via Revolizer significantly improved asthma control, peak flow and quality of life of patients with persistent asthma.
This slide set covers the epidemiology, disease progression and management of HIV-HCV coinfection in the era of directly acting antivirals available for HCV management.
This study compared the enhanced and standard antimicrobial prophylaxis treatment in patients with advanced HIV disease.
Methotrexate (MTX) is the first-line treatment for early and clearly defined rheumatoid arthritis (RA). This presentation summarizes the recommendations for dose up and downscaling and route of administration of MTX based on scientific evidence for decision-making in the treatment of adult RA.
Ulcerative colitis is a complex, chronic disease that affects the digestive tract, particularly the colon. An introduction to this disease is given in this slide set.
The latest ADA recommendations (2017) on antihyperglycaemic therapy for type 2 diabetes management have been provided in a easy-to-use format. It provides information on usage of oral as well as insulin therapy in type 2 diabetes patients.
Ocular complications may occur in patients with ulcerative colitis. This slide set describes the ocular manifestations that may affect ulcerative colitis patient.
Non alcoholic fatty liver disease is a spectrum of disorders that affects the liver. It has become one of the most common liver disease in the world. It is expected to become the largest reason for liver transplant in the future. The disease and its management is covered briefly in this slide set.
Hepatitis C is a viral infection that affects liver of 170 million people across the globe. It is one of the largest causes of liver cirrhosis and liver cancer globally. Each year around 700, 000 people due to Hepatitis C. In this slide set, the prevalence, genotypes, it diagnosis and treatment has been covered.
Pomalidomide, low dose dexamethasone is safe and effective in moderate RI relapsed/refractory multiple myeloma patients.
This study support the use of 4 mg of pomalidomide as an effective starting dose; and the use of pomalidomide-dexamethasone, regardless of age in RRMM patients.
Pomalidomide, low dose dexamethasone is safe and effective in moderate RI relapsed/refractory multiple myeloma patients.
Pomalidomide-dexamethasone is a standard of care in patients with relapsed/refractory multiple myeloma following exhaustion of treatment options.
The GOLD 2017 Update is the fourth major revision since the last GOLD 2011 Update. It has some significant changes in guideline recommendations with respect to definitions, diagnosis and treatment. The GOLD 2017 gives a revised definition of COPD and refined ABCD assessment tool. Treatment recommendations are tailored to “patients’ needs” i.e. patient’s perception on symptom control, escalation and de-escalation of pharmacotherapy. The assessment and regular evaluation of adherence and inhaler technique for patients with COPD has been added. Management of exacerbations and comorbidities in COPD patients have been updated.
The diagnosis of PH requires a clinical suspicion based on signs and symptoms, followed by review of a comprehensive set of investigations to confirm that haemodynamic criteria are met and to describe the aetiology and the functional and haemodynamic severity of the condition.
The current treatment strategy for PAH patients includes initial approach with general measures, followed by initiating therapy with high-dose CCB in vasoreactive patients or drugs approved for PAH in non-vasoreactive patients according to the prognostic risk of the patient. The importance of expert referral centers and upfront combination therapy in the management of PAH patients has been highlighted in the revised treatment algorithms.
This algorithm, for management of melasma is based on clinical experience of eminent dermatologists of India and review of the evidence from available literature.
This algorithm gives the sequence that should be followed while diagnosing diseases of chronic airflow limitation in a patient.
The latest ADA recommendations (2017) on diabetic kidney disease – including screening, diagnosis and management have been summarized in a reader-friendly infographic format.
This trial reported higher ovulation rates with letrozole in women with polycystic ovarian syndrome than with clomiphene citrate. However, the differences in the pregnancy rates and outcome were not significant.
The latest ADA recommendations (2017) on diagnosis and management of diabetes have been summarized in an easy-to-use infographic format.
The proposed treatment algorithm for the management of status epilepticus (adapted from evidence-based guidelines by American Epilepsy Society) starts with a stabilization phase (0-5 minutes) which includes standard initial first aid for seizures. If seizure continues, initial therapy (5-20 minutes) with benzodiazepines, second-therapy phase (20-40 minutes), and third-therapy phase (40-60 minutes) should be carried out.
Treatment of epilepsy in women can be challenging and requires special considerations regarding antiepileptic use in women. The important factors to be considered in the management of epilepsy in women are the choice of antiepileptic drugs and their effects on sexual function, contraception, pregnancy, fetal development, lactation, and menopause.
The article consists of basic information on schizophrenia, common myths associated with it, general management and caregiving tips.
The present review and meta-analysis supports the early use of adjunctive fenofibrate therapy in diabetes patients for the prevention of microvascular complications.
Caregiver’s guide contains basic understanding of schizophrenia and general caregiving and healthy living tips for the patients and their caregivers.
The present study provides a comparison on the effectiveness of the four first-line medication groups for the reduction of IOP in POAG patients.
Here are some healthy practices that will help prevent typhoid – one of the most common communicable diseases in India.
The Technical dossier on Minizerostat spacer provides details on the role of spacers as an add on device to pMDI, focusing on the product characteristics of Minizerostat spacer, its technical details and performance.
The present study demonstrated that polyethylene glycol can effectively treat functional constipation especially in children aged above 6 months.
As per the study sacubitril/valsartan causes greater reduction in HbA1c vs. enalapril and cuts new insulin initiation in diabetes patients with HFrEF.
This slide set covers the common musculoskeletal manifestations of inflammatory bowel diseases (IBD) and its management. The spectrum of these manifestations vary according to the type of IBD. IBD-associated musculoskeletal disorders include: arthritis, periarticular inflammation, metabolic bone disorders and impaired growth.
As per the study, prostaglandin analogue monotherapy brings about long-term intraocular pressure reduction in patients with primary open angle glaucoma
This user-friendly tool developed by Harvard School of Public Health estimates a healthy individual’s 20-year risk of CVD.
In this video Dr Arup Dasbiswas highlights the superiority of the new generation thrombolytic (reteplase) over older generation agent, streptokinase.
Treatment for chronic hepatitis C has evolved rapidly from an interferon based regimen of modest efficacy with significant adverse events to a well-tolerated, highly effective all-oral directly acting antiviral (DAA) therapy. It is the first DAA that has shown safety and efficacy to treat genotype 3 chronic HCV infections without the need for co-administration with interferon or ribavirin in most patients except cirrhosis. Daclatasvir, especially in combination with other antiviral agents such as sofosbuvir, is a very promising drug for the treatment of chronic hepatitis C in HCV genotype 3 patients This slide set gives an overview on the pharmacokinetics, efficacy, safety and place in therapy for daclatasvir- sofosbuvir combination in chronic hepatitis C.
Guidelines for UTI management, summarised for gastroenterologists.
Treatment with Omalizumab for 6 years resulted in clinical improvement in patients with severe asthma, even after 3 years of withdrawal of the drug.
In this video. Dr Ajit Bhagwat shares some interesting studies to show why one of the newer generation thrombolytic agent is better than another.
This key trial noted that transumbilical (TUI) and periumbilical incision (PUI) during general surgery laparoscopic interventions were similar for all tested outcomes.
A study presented at AICOG 2017, highlights treatment, safety and indications of sustained release formulations of natural micronized progesterone.
The first Indian physician-based survey which provides unique insights on managing dyslipidemia in routine clinical practice published in the peer-reviewed ‘Lipids in Health and Disease’ journal.
The Indian Council of Medical Research–INdia DIABetes (ICMR-INDIAB) study is an ongoing study initiated to estimate the national prevalence of diabetes and prediabetes in India. The study revealed a great variation in the prevalence of diabetes across the country. Diabetes epidemic seems to be gaining a more severe form in economically advanced states of India. Preventive measures are important in economically backward regions of the country owing to the spread of the epidemic in such regions.
American Thoracic Society (ATS) 2017 conference was conducted on 19-24 May 2017 at Washington DC, US. It marked the 113th year of the conference, making it the longest running, large-scale conference in the world offering groundbreaking research in pulmonary, oncology, and sleep medicine.
Highlights of the ATS 2017 emphasizes on role of drugs, risk factors, importance of devices and relevant therapy updates in asthma, COPD, IPF, PH, tuberculosis, lung cancer, and other pulmonary diseases. In addition, the highlights cover the newer research on both therapy and investigational new drugs in respiratory medicine.
Treatment for chronic hepatitis C has evolved rapidly from an interferon based regimen of modest efficacy with significant adverse events to a well-tolerated, highly effective all-oral directly acting antiviral therapy. Specifically, the combination therapy sofosbuvir and velpatasvir offers a pangenotypic regimen with high sustained viral response. Availability of this highly efficacious, well tolerated, all oral regimen formulated as a single pill, can potentially simplify hepatitis C treatment. This slide set gives an overview on the pharmacokinetics, efficacy, safety and place in therapy for sofosbuvir - velpatasvir combination in chronic hepatitis C.
Treatment for chronic hepatitis C has evolved rapidly from an interferon based regimen of modest efficacy with significant adverse events to a well-tolerated, highly effective all-oral directly acting antiviral therapy. Specifically, the fixed dose combination therapy, sofosbuvir and ledipasvir offers a single pill once daily regimen with high sustained viral response especially in HCV genotype 1 infection. Availability of this highly efficacious, well tolerated, all oral regimen formulated as a single pill, can potentially simplify hepatitis C treatment. This slide set gives an overview on the pharmacokinetics, efficacy, safety and place in therapy for sofosbuvir - ledipasvir combination in chronic hepatitis C.
Inflammatory bowel diseases-associated hepatobiliary disorders include: autoimmune hepatitis/ primary sclerosing cholangitis overlap syndrome, IgG4-associated cholangiopathy, primary biliary cholangitis, hepatic amyloidosis, granulomatous hepatitis, cholelithiasis, portal vein thrombosis and liver abscess. The spectrum of these manifestations varies according to the type of inflammatory bowel diseases. Successful therapy of EIM is essential for improving quality of life of patients with IBD. This slide set covers the common liver manifestations and its management.
Extra intestinal manifestations are common in patients with inflammatory bowel disease. These manifestations can affect different organ systems of a patients. The skin and the mucosa often affected as a result of inflammatory bowel disease. Common manifestations when this organ system is affected includes Erythema Nodosum, Pyoderma Gangrenosum, Sweet’s syndrome and Aphthous Stomatitis. Successful therapy of EIM is essential for improving quality of life of patients with IBD. This slide set covers the common skin manifestations and its management.
Majority of patients with a confirmed diagnosis of RA use nonbiologic DMARDs. The rate of biologic DMARDs use in RA treatment is also rising rapidly. This presentation summarizes the ACR 2015 recommendations for the use of non-biologic and biologic DMARDs in patients with RA.
This study was conducted to evaluate the safety and efficacy of mifepristone and misoprostol in induction of second trimester abortions. The combined regimen was safe and effective and reduced the induction-to-abortion time. Time taken for complete abortion was more in nullipara as compared to multipara.
Depression is under-diagnosed and under-treated in patients with epilepsy. Epilepsy is a complex disease which is frequently associated with other co-morbid neuropsychiatric diseases such as migraine, anxiety and depression. ‘Mind Matters Issue -5 – Escitalopram: Depression Associated with Epilepsy’ sheds light on the following topics – Diagnosis of Depression in Epilepsy, Impact of the Bidirectional Relationship between Depression and Epilepsy, Clinical Presentation of Depression in Patients with Epilepsy, Impact of Untreated Depression in Epilepsy Patients, Treatment of Depression in Epilepsy Patients.
Up to 3% of pregnant women suffer from pregnancy-associated liver diseases, which are the most frequent cause of liver dysfunction in pregnancy. Due to significant morbidity and mortality for both mother and infant in severe cases, a rapid evaluation is essential to distinguish it from non-pregnancy-related liver dysfunction. Besides, liver disease unrelated to pregnancy can present de novo in pregnancy, or pregnancy can occur in women with pre-existing liver pathology. The risks of pregnancy in women with pre-existent liver pathology and recent advances in our understanding of specific risks and outcomes has been recently discussed in the study by Westbrook, Rachel H. et al. published in the Journal of Hepatology (J Hepatol. 2016;64:933-45). This booklet aims to provide an overview on the liver diseases specific to the pregnancy and an update on their pathogenesis, treatment and outcomes.
A study was conducted to determine the incremental impact of sacubitril/ valsartan (an angiotensin receptor-neprilysin inhibitor) over enalapril on the nonfatal progression of heart failure (HF) in surviving HF patients. According to the findings, sacubitril/valsartan treatment was superior to enalapril in preventing the clinical progression of surviving HF patients.
Pre-conception is the period during which many couples plan their pregnancy. Pre-conception care provides an opportunity to a couple to improve their health before trying for a baby. During this time, even the male partner needs to make lifestyle and diet changes such that they can help in conception.
Prostate is one of the most common cancers in men. This material describes risk factors, symptoms, diagnosis and treatment of prostate cancer. Also, tips to prevent risk of prostate cancer are given in a simple manner.
Tips for patient with leukaemia and lymphoma are explained along with pictures for better understanding.
Risk factors, signs & symptoms, factors known to reduce ovarian cancer, diagnosis, treatment options and how to reduce risk of ovarian cancer given along with relevant pictures for better understanding.
Throughout the years there have been many cancer myths floating around. This article will help clear the myths related to cancer.
Different types of lung surgeries, recovery after surgery and do’s and don’ts have been given in patient friendly language. Information on possible risks, side effects and role of surgery in metastasis along with tests to be performed before lung cancer surgery have been described in brief.
Infection during cancer, causes, sign and symptoms and tips for prevention are given in this patient education material in a simplified manner.
This patient education material gives information on types of colon surgeries, tips for preparing for surgery, what to expect before and after surgery. It also gives do’s and don’ts for patients undergoing colon surgery.
Different types of leukaemia has been classified in this document with focus on chronic myeloid leukaemia. Causes/risk factors, sign and symptoms, detection of chronic myeloid leukaemia have been described with relevant pictures.
Among all body organs, eye manifests drug toxicity, second only to the liver. Ocular disorders occur not only from topical drugs, but also from their systemic administration. The current presentation gives a brief on the ocular manifestations of systemic medications and its management.
The PARADGM-HF study demonstrated that angiotensin receptor neprilysin inhibitor (sacubitril/valsartan) was superior to enalapril in reducing the risk of death and hospitalization due to HF in patients with HFrEF.
NISTAMI® Inhaler contains combination of Indacaterol maleate (110 mcg) and Glycopyrronium bromide (50 mcg) in one capsule. NISTAMI Dossier gives a brief overview of indications, dosage and pharmacology of dual bronchodilation. Dossier also covers clinical studies on efficacy of dual bronchodilators along with safety data, inhaler instructions and other important clinical data.
NISTAMI® Inhaler is indicated as a once-daily maintenance bronchodilator treatment to relieve symptoms and reduce exacerbations in COPD patients. The recommended dosage of NISTAMI® Inhaler is once-daily inhalation of the content of one 110/50 microgram capsule using NISTAMI® Inhaler.
Hepatitis C virus (HCV) infection during pregnancy is an emerging problem. While not negatively affecting acute hepatitis, it may exacerbate chronic hepatitis and worsen liver function in woman with liver cirrhosis. The burden of HCV in pregnant women is largely underappreciated. New HCV antiviral regimens based on direct-acting antiviral agents without interferon have greatly expanded the pool of patients eligible for treatment and have dramatically improved treatment outcomes. This slide set discusses the management of hepatitis C infection in pregnancy.
Advances in hepatitis B treatment has now reached the clinic. The latest developments for clinicians in hepatitis B discussed at EASL 2017 is covered here.
Hepatic encephalopathy continues to be a vexing problem for clinicians. Different approaches discussed at EASL 2017 have been covered in this booklet.
Hepatitis C underwent an evolution with the introduction of the new direct acting antivirals. The latest drug to be introduced, velpatasvir, has been discussed at EASL 2017. This along with real world evidence presented at EASL 2017 in different populations is covered here.
Causes, signs and symptoms, prevention, diagnosis and treatment of liver cancer has been described in this article.
Basic understanding of cervical cancer including risk factors, symptoms, diagnosis and prevention is explained in this article.
Most women diagnosed with breast cancer often need surgery to remove the tumour. Different types of surgeries and changes expected after surgery and tips for faster recovery have been mentioned in this article.
Alcoholic liver disease includes a broad spectrum of entities from simple steatosis, acute alcoholic hepatitis with or without underlying cirrhosis, to hepatocellular carcinoma as a complication of cirrhosis. The approach to management of this condition along with the latest developments are covered in this slide set.
Breastfeeding is meant to be a comfortable and pleasant experience. It is also an integral part of the reproductive process with important implications for the health of mothers. This presentation contains information about the care to be taken during breastfeeding and some tips to prevent or treat certain problems or discomforts associated with it.
Congenital cataract is the most common cause of treatable childhood blindness. Even though pediatric cataract surgery is evolving, intraocular lens (IOL) power calculation & selection represents a major challenge. The current presentation gives a brief on important points to remember while calculating IOL power in children.
The Acetaminophen versus Ibuprofen in Children with Asthma (AVICA) was initiated to determine whether the use of acetaminophen vs. ibuprofen under clinical indication would result in higher morbidity related to asthma in children with mild persistent asthma. The findings revealed no differences in terms of the incidence of asthma exacerbations or asthma-related complications with the as-needed use of acetaminophen vs. ibuprofen over a period of 48 hours.
Results of the EUCLID trial, ticagrelor was not superior to clopidogrel in terms of reducing CV events in patients with symptomatic peripheral arterial disease (PAD). Although the incidence of major bleeding was similar with both the medications, ticagrelor was more often discontinued owing to dyspnea and minor bleeding events.
Radical prostatectomy is a common treatment for patients with localized prostatic cancer but more than 30% of such patients will subsequently have a recurrence. This randomized study reports the 12 year results of comparative effectiveness of radiation therapy (RT) with or without bicalutamide in treating patients who have stage II, stage III, or recurrent prostate cancer and elevated PSA levels following radical prostatectomy. Addition of antiandrogen therapy to salvage radiation therapy showed significantly higher rates of long-term overall survival and lower incidences of metastatic prostate cancer and death from prostate cancer than radiation therapy plus placebo.
It is recognized that around 5-10% of patients with asthma have severe disease which remains inadequately controlled; despite high-dose ICS/LABA and additional controller medication if required. Due to the associated morbidity, these patients represent an important segment of asthma population. This slide set focuses on the identification, management and advances in severe asthma.