A research was conducted to investigate the relationships between cardiovascular mortality in persons with type 2 diabetes mellitus (T2DM) and the system inflammation index, which includes the system immune-inflammation index (SII) and system immune inflammation index (SIRI). 2,954 participants from the National Health and Nutrition Examination Survey (NHANES) for the years 1999–2010 were included in the study, according to the sources. Through December 31, 2019, data from the National Death Index (NDI) was linked to determine cardiovascular mortality. To calculate the 95% confidence intervals (CIs) and hazard ratios (HRs), Cox proportional hazards regression models were employed. There were 248 fatalities from cardiovascular disease (CVD) over an average of 12.4 years of follow-up. Following multivariate correction, there was a significant dose-response relationship (P nonlinear = 0.26) between a one-unit rise in SIRI and a 16% greater risk of cardiovascular death (P <0.0001). On the other hand, there is a J-shaped link (P nonlinear = 0.03) between SII and CVD deaths. When comparing extreme levels of SII, the multivariate-adjusted HR for CVD deaths was 1.81 (95% CI 1.11, 2.95) (P trend = 0.017). Among those with T2DM, a higher SIRI and extremely high SII were linearly correlated with an increased risk of cardiovascular death.

457-P: American Diabetes Association (ADA) 84th Scientific Sessions, 2024, 21- 24 June 2024, Orlando, Florida.