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Evaluation of Long-term Risk of Epilepsy, Psychiatric Disorders, and Mortality Among Children With Recurrent Febrile Seizures: A National Cohort Study in Denmark

A history of recurrent febrile seizures appears to be associated with a risk of epilepsy and psychiatric disorders, but increased mortality was found only in individuals who later developed epilepsy.

Association between body positioning and gastroesophageal reflux in pediatric age

Most paediatric patients experienced reflux in the upright rather than recumbent position, probably as a result of frequent transient lower oesophageal sphincter relaxations while they were awake. In particular, our findings provide new insights on postural measures for reflux in children and adolescents.

Longitudinal changes in bone mineral density in children with inflammatory bowel diseases

Improvement in BMD was more pronounced in children who gained weight or whose BMD was low at the first scan.

Global Prevalence of Hypertension in Children: A Systematic Review and Meta-analysis

This study provides a global estimation of childhood hypertension prevalence based on blood pressure measurements in at least 3 separate visits. The findings suggest that childhood hypertension is becoming more common in the general pediatric population, representing a considerable public health challenge worldwide.

Association of Positive Family Relationships With Mental Health Trajectories From Adolescence To Midlife

The findings suggest that positive adolescent family relationships are associated with better mental health among females and males from early adolescence to midlife. Interventions in early family life to foster healthy mental development throughout the life course appear to be important.

Serum Pentraxin 3 Concentration in Neonatal Sepsis

The present study showed that serum pentraxin 3 levels may be a useful marker in the diagnosis of neonatal sepsis.

Intestinal microbiome analysis demonstrates azithromycin post-treatment effects improve when combined with lactulose

It is suggested that during azithromycin treatment, lactulose is able to reinstate the microbiome equilibrium much faster as it promotes saccharolytic microbes and provides a homeostatic effect that minimizes the opportunistic pathogen colonization.

Early Enteral Nutrition Is Associated With Improved Clinical Outcomes in Critically Ill Children

In critically ill children with hyperglycemia requiring inotropic support and/or mechanical ventilation, early enteral nutrition was independently associated with better clinical outcomes .

Prevalence of Immunodeficiency in Children With Invasive Pneumococcal Disease in the Pneumococcal Vaccine Era: A Systematic Review

Results of this study suggest that invasive pneumococcal disease, and particularly recurrent IPD, is an important marker of underlying PID in children without other risk factors. The findings also suggest that children older than 2 years with pneumococcal meningitis or complicated pneumonia and all children with recurrent IPD should be referred for an immune evaluation.

Acanthosis nigricans in childhood: A cutaneous marker that should not be underestimated, especially in obese children

In clinical practice, the recognition of acanthosis nigricans is useful for an early identification of children and adolescents, prone to the insulin‐resistant obese phenotype, who could benefit from early interventions.