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8 Jan, 26
The updated AHA statement expands on prior evidence, presenting new data that reinforce the link between periodontal disease and atherosclerotic cardiovascular disease, while underscoring possible mechanisms and existing knowledge gaps.
6 Jan, 26
The 2025 ACC guidance highlights critical care in cardiogenic shock by recognizing the hemodynamic impact of PEEP on ventricular function, selecting invasive ventilation when instability warrants, and applying early structured interventions during the Golden Hour to support perfusion.
21 Jan, 26
JAMA Cardiol.
- In 27748 women (median age 53 y, follow-up 27.8 y), Lp(a) >30 mg/dL or ≥75th percentile (31 mg/dL) raised 30 yr risk of major CV events/CHD
- Very high levels >120 mg/dL or ≥99th percentile (131 mg/dL) vs. <10 mg/dL or > 99th percentile vs 50th percentile (11 mg/dL) raised risk for MACE (HRs:1.54, 1.74), CHD (1.80, 2.06), ischemic stroke (1.41, 1.85), & CV death (1.63, 1.86)
- rs3798220 carriers had higher CV risk.
21 Jan, 26Diabetes Res Clin Pr...
- In a cohort of 114293 Chinese adults (mean follow-up 3.1 y; 2435 T2DM cases) IR indices (TyG, TyG-BMI, TG/HDL-C, METS-IR) predicted diabetes risk, strongest in non-overweight (reverse gradient for all indices)
- Adjusted HRs for TyG were 4.60, 3.10, 2.62 in non-overweight, overweight, obese grps; TyG AUC (non-overweight): 76.74%
- Replication in 15453 Japanese confirmed findings, highlighting early risk in non-obese.
19 Jan, 26Cureus.
- N=22,125 specimens, with 22.9% culture positives (Nagpur, India)
- Gram‑negative bacteria predominated (80.4%), chiefly E. coli, K. pneumoniae, P. aeruginosa, and Acinetobacter
- Among Gram‑positives, 66.1% of S. aureus were MRSA and 4.6% of Enterococcus were vancomycin-resistant Enterococcus
- Resistance was high to cephalosporins (>70%) and fluoroquinolones (>40%)
15 Jan, 26Diabetes Metab Syndr...
- Secondary analysis of NFHS 5 (2019–2021; n=788974) identified 1351 low BMI diabetes cases (BMI<18.5 kg/m², FBG ≥126 mg/dL, RBG ≥200 mg/dL)
- Weighted prevalence was 0.19%, & higher in males (0.25% vs 0.18%, p=0.006) & concentrated in poorest quintiles (54%), national estimate on adjusting for 50% undiagnosed cases was 2.42 M Indians <50 y
- “T5DM” burden is lower, lean T2DM driven by visceral adiposity predominates.
The management of pediatric asthma is evolving with newer approaches such as anti‑inflammatory reliever (AIR) therapy and SMART (single maintenance and reliever therapy) using budesonide–formoterol, which offer better outcomes than conventional treatment strategies. Novel breath‑actuated devices like the Synchrobreathe, known for their ease of use and training in adults with obstructive airway diseases, may also be p...
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