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2 Jan, 26
AOCCN 2025
Key session presented at the 17th Asian Oceanian Child Neurology Congress, 2025, on developmental and behavioural disorders.
31 Dec, 25AOCCN 2025
Key session presented at the 17th Asian Oceanian Child Neurology Congress, 2025, on developmental and behavioural disorders.
2 Jan, 26Diabetologia.
- In young T1DM patients from the DISS & NDR cohorts, those who developed diabetes-related complications had higher serum uric acid (UA) levels at diabetes diagnosis vs those without complications (209.2 vs 171.7 µmol/l)
- Each 1 µmol/l rise raised odds by 1%; top quartile UA conferred >3× risk, independent of age, HbA1c, smoking, & eGFR
- Higher UA levels may be linked to micro-& macrovascular complications in T1DM.
30 Dec, 25Am J Obstet Gynecol.
- 40 RCTs (n≈5,408) included
- Diuretics (7 trials, n=1113) improved BP control with antihypertensives but not alone
- Antihypertensive comparisons (12 trials, n=961) showed enalapril/amlodipine more effective than nifedipine; diltiazem lowered BP vs. nifedipine in severe cases (n=403)
- BP self-monitoring/lifestyle change (9 trials, n=1263) reduced BP at 8 months postpartum.
29 Dec, 25Endocr Pract.
- A study of 124 youths (mean age 12.9 y, T1DM duration 6.0 y; HbA1c 8.1%, glucose TIR 49%) showed mean BMD z-score –0.2 (lower than pediatric norms)
- BMD z-score correlated with BMI z-score (r=0.32, p=0.0002), TIR (r=0.24, p=0.007), 25OHD (r=0.22, p=0.01), & high-impact activity EE (r=0.02, p=0.03)
- 51% of the study population was vit D deficient, vit D deficiency lowered BMD (Δ0.7); activity raised BMD (Δ0.3)
26 Dec, 25Diabetes Obes Metab.
- A meta-analysis of 19 studies (n=1,371,533) found CKD prevalence in T1DM at 22.3%; highest in Americas (27%), lowest in Europe (19.4%)
- Prevalence was higher in adults vs adolescents (20.5% vs 10.5%); with duration ≥10 y vs <10 y (21.8% vs 16.4%); HbA1c ≥8% vs <8% (27.7% vs 17.9%)
- Meta-regression confirmed the link between higher HbA1c & CKD prevalence
- Regular screening is essential to mitigate CKD burden in T1DM.
12 Dec, 25
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