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18 Nov, 25
The ESI obesity management guidelines are based on the fast-changing obesity epidemiology & pharmacological options. The novel concepts in the psycho-social aspects & medication counselling of obesity management have also been explored.
18 Nov, 25
The prevalence of obesity has been increasing rapidly in India as well as globally. The clinical practice guidelines from the Endocrine Society of India (ESI) guide the healthcare providers on optimizing the management of obesity.
28 Nov, 25
Diabetologia.
- Impact of daily life stress was ascertained in 116 subjects [62 insulin-resistant [IR] & 54 insulin-sensitive (IS); age 18-78 yrs]
- Stress level correlated positively with blood glucose level (p=0.005) only in IR, stress levels predicted negative impact in both IR (p<0.001) & IS (p<0.001) subjects
- Integrating stress management strategies is essential for diabetes prevention in at-risk populations.
28 Nov, 25BMC Infect Dis.
- Fever of origin (FUO) analysis (N=100; mean age 45.1) showed diagnosis: CVD (39%) > infections (19%) > malignancies (17%); 13% undiagnosed
- Vasculitis (25.6%) predominated in CVD; TB (36.8%) in infections; lymphomas (52.9%) in malignancies
- PET-CT had highest diagnostic yield (p=0.004)
- CRP ≥140 mg/L, low Hb, HIV+, ferritin ≥875 µg/L predicted malignancy (p=0.01)
- HIV subgroup: infections 46%, malignancy 38%
28 Nov, 25Int J Pediatr Otorhi...
- This 10-year study of 109 children hospitalized for acute bacterial rhinosinusitis found that asthma and prior NSAID use was linked to higher risk of complications
- Elevated CRP, and lymphopenia were key predictors of severity and anaerobic Streptococci was linked to severe infections
- Early imaging and vigilant management are recommended for high-risk patients to prevent complications and treatment failure.
27 Nov, 25Diabetes Obes Metab.
- As per network meta analysis of 26 RCTs (143,296 T2DM patients with CKD) vs other antidiabetic medications, SGLT2 inhibitors were most effective in reducing renal outcomes (P score 0.94), eGFR decline >40%/RRT (0.99), MACE (0.93) & HF (1.00)
- GLP 1 RA reduced MI (0.87), macroalbuminuria (0.86) & stroke (0.83)
- Both SGLT2i & GLP 1 RA lowered all cause mortality (0.83), while DPP 4i offered limited benefit.
19 Nov, 25
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