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18 Nov, 25
The ESI obesity management guidelines are based on the fast-changing obesity epidemiology & pharmacological options. The novel concepts in the psycho-social aspects & medication counselling of obesity management have also been explored.
18 Nov, 25
The prevalence of obesity has been increasing rapidly in India as well as globally. The clinical practice guidelines from the Endocrine Society of India (ESI) guide the healthcare providers on optimizing the management of obesity.
19 Nov, 25
Eur Heart J.
- Amongst 4366 CARDIA subjects, 241 ASCVD events were recorded after age of 40 yrs (mean follow-up: 19.3 yrs)
- Cumulative exposure to apoB, LDL-P, & TRL-P from age 18-40 increased ASCVD risk after 40, with a 1 SD higher exposure yielding HRs of 1.53, 1.54, & 1.48, respectively (aHR≈ 1.30), usual apoB exposure ≥75 mg/dL/year raised the ASCVD risk
- Targeting apoB <75 mg/dL may reduce ASCVD incidence in young adults.
19 Nov, 25
Int J Infect Dis.
- As per national survey of physicians (France), amoxicillin was preferred first-line therapy, prescribed in 69% for 14 days and 29% for 21 days, mostly at 80–100 mg/kg/day
- Linezolid was preferred in penicillin-allergic patients; levofloxacin was common but often deemed inappropriate
- Therapeutic abstention was frequent with catheterization, polymicrobial cultures, or leukocyturia <10⁴/mL.
17 Nov, 25
BMC Pediatr.
- In preschoolers with autism spectrum disorder, high screen time (ST) was linked to higher anxiety/depression scores (60.02 vs. 50.17, p=0.03) and reduced left superior frontal cortical volume (25,232.13 vs. 26,441.19, p=0.02) vs. low ST
- ST correlated positively with anxiety/depression (p=0.02) and negatively with cortical volume (p<0.001)
- The link between ST & anxiety/depression was attributed to cortical volume.
14 Nov, 25
Lancet Neurol.
- Prevalence of headache disorders was 34.6% (in 2023) globally, causing 541.9 years lived with disability (YLDs)/1,00,000 population, with migraine being most common (487.5/1,00,000)
- Women had over twice the rate of YLDs vs. men (739.9 vs. 346.1/1,00,000)
- Medication-overuse headache significantly amplified burden (56·1%-58·9% of YLD estimates for tension-type headache & 14·1%-22·6% of YLD estimates for migraines)
19 Nov, 25
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