In 701 DPP participants with T2D, younger-onset was linked to higher FPG, BMI, DBP, lower HDL, smaller BP/lipid improvements, and rising HbA1c over 7.9 years. Older-onset had higher SBP, lower eGFR, and stable glycaemia. Younger-onset were more often on glucose-lowering drugs. Findings highlight worse metabolic progression in early-onset T2D despite better renal and BP profiles.

Among 328 new T2DM patients in India, ~50% were <45 years. Mean BMI was 26.9 kg/m²; 52% had family history (more maternal). Hypertension (31%), dyslipidaemia, and neuropathy were common, with Group B (>45 yrs) showing higher weight loss, hypertension, and neuropathy. Findings highlight early onset, family risk, and prevalent complications in Indian T2DM.

A study unveiled that worsening cardiovascular-kidney-metabolic (CKM) syndrome stages markedly increased dementia risk. Compared to stage 0, the risk increased by 25% in stage 2, 35% in stage 3, and 80% in stage 4. Even those in stage 2 having multiple CKM risk factors raised the risk. Advanced stage was tied to a 62% higher dementia risk. Inflammatory markers like SII, SIRI, and AISI mediated this link.

Aortic stiffness, measured by carotid-femoral pulse wave velocity (cfPWV), could serve as a prognostic tool for cardiovascular outcomes in diabetic patients, according to a meta-analysis. Every 1 m/s rise in cfPWV corresponded with a 7% increase in cardiovascular events and all-cause mortality. Patients with elevated cfPWV had a 1.71-fold higher risk of cardiovascular events than those with lower values (HR 1.71).

Most coronal knee deformities in younger children under 8 with healed nutritional rickets correct spontaneously within a year. In this study, younger children (<8 years) had higher rates of successful remodeling compared to those over 8 years (OR 16.4). Deformities ≤16.5° for valgum and ≤13° for varum demonstrated greater remodeling potential. Sex, deformity direction, and laterality had no influence.

Thyroid hormone sensitivity indices may signal elevated MACCEs risk in ACS patients after PCI. Higher thyroid-stimulating hormone index and especially parametric thyroid feedback quantile-based index (PTFQI) correlated with increased MACCEs risk (HR 1.24). Addition of PTFQI into the GRACE score improved risk prediction (AUROC 0.759 vs 0.646). The predictive value was robust in men & those with abnormal blood glucose