Fluticasone + Salmeterol More Effective than High Dose Fluticasone

18 Mar, 14

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Fluticasone + Salmeterol is More Effective than High Dose Fluticasone in Indian Asthmatics

Objective

To compare efficacy of Fluticasone + Salmeterol (Seroflo; 100/50 mcg; Cipla Ltd., India) combination versus doubling the dose of Fluticasone (200 mcg; Cipla Ltd., India).

Patients and Methods

Randomized, double-blind, parallel-group, multicentre study.
Asthmatic subjects aged 18 years and above.
115 subjects were included and randomised to a 12 weeks treatment with Fluticasone 200 mcg b.i.d. or Fluticasone + Salmeterol 100/50 mcg b.i.d.

Results

There was significant increase in morning PEF (mean difference: 40L/min; p = 0.006) & FEV₁ (mean difference: 0.17L; p=0.008) with the Fluticasone + Salmeterol group compared to high dose Fluticasone at 12 weeks.

Fluticasone + Salmeterol provided better control on daytime and night-time symptoms.
Patients in the Fluticasone + Salmeterol group were more likely to have rescue free days (27% increase).

Conclusion

Fluticasone + Salmeterol combination provides better asthma control compared to doubling the dose of Fluticasone.
Both the treatments were well tolerated.

2771, presented at European Respiratory Society (ERS) Conference, 2005

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Related Topics

rescue medication

night-time symptoms