Postmarketing Surveillance Study on Amlopres-AT (Amlodipine/Atenolol Combination)

19 Apr, 14

Efficacy and tolerability of a fixed-dose combination of amlodipine and atenolol (Amlopres-AT) in Indian hypertensives
A Post Marketing Surveillance Study

Aim

To assess the antihypertensive efficacy and safety of a fixed-dose combination of amlodipine and atenolol (Amlopres-AT) in Indian patients

Study Patients

Patients with moderate hypertension or hypertension not controlled by either amlodipine or atenolol alone (N=370)

Study Medication

Amlopres-AT (Amlodipine 5 mg and atenolol 50 mg) once daily Dosage increased or decreased or maintained at 2 weeks as per patient response

Study Duration

4 weeks

Results

Treatment with Amlopres-AT showed significant reduction in blood pressure

Satisfactory BP control was observed in 80.5% of patients with Amlopres-AT
The combination showed significant reduction in heart rate and also reduced the frequency of angina attacks in patients with concomitant angina

* p<0.05

Treatment with Amlopres-AT was associated with a low incidence of side effects. Commonly seen side effects were oedema, fatigue and headache.

Conclusion

The once daily regimen of the fixed-dose combination of amlodipine and atenolol (Amlopres-AT) provided a significant antihypertensive effect and was well tolerated in Indian patients

The Indian Practitioner 1997: 50; 683-688