Introduction

Natural micronized progesterone (NMP) and its sustained release formulation (NMP-SR) are being prescribed by the gynaecologists in India for different indications. However, there is still paucity of Indian data on its practical usage.

Aim

To help analyse the prescription pattern of NMP and NMP-SR in Obstetrics & Gynaecology.

Materials & Methods

A questionnaire based survey was carried out amongst Indian Obstetricians & Gynaecologists. Questions were asked related to the molecule, treatment pattern, safety and indications.

Results

Across India, 841 doctors participated in this survey. Out of the total responders, NMP-SR was prescribed by 52.2% doctors and 47.78% prescribed NMP. The preferred route of administration for NMP was vaginal (62.4%) and oral for NMP-SR (88.7%). NMP-SR was administered vaginally by 10.8%. For both NMP & NMP-SR, 200 mg was the most preferred strength and 200 mg BID was the most preferred dosage regime for different approved indications. Effectiveness was the most important and cost was the least important factor taken into consideration before prescribing both formulations. Giddiness was reported by 40% and drowsiness by 33% doctors as the common side effects; 20% doctors reported none.

Conclusion

Owing to their acceptable efficacy and tolerability, NMP and NMP-SR were almost equally preferred as progesterone support in Obstetrics & Gynaecology. Though rectal route is recommended as an alternate option in case vaginal route of administration is not possible, doctors didn’t prefer this route for NMP. An unusual finding was that NMP-SR was administered vaginally by few doctors, though this route is not indicated for this formulation. Most of the doctors considered effectiveness as the most important factor to prescribe both formulations.

Note: Percentages are calculated based on available data (n).

e-poster 777; Mandrupkar Gorakh, Ahluwalia S. PRECIOUS - PRactical obsErvational study to evaluate the Clinical use of plaIn and sustained release fOrmulation of natUral micronized progesterone. Presented at 60^th All India Congress of Obstetrics & Gynaecology, 2017 January, Ahmedabad, India.