Safety and Efficacy of Tiotropium + Formoterol in Patients with COPD

18 Mar, 14

0

0

Tiotropium + Formoterol is Safe and Effective in Indian COPD Patients

Objective

To compare the bronchodilator response of Tiotropium + Formoterol (Duova, Cipla Ltd., India) combination vs. Tiotropium alone in COPD patients.

Patients and Methods

Randomised, double-blind, crossover study.
24 male COPD subjects were included and randomised to either Tiotropium + Formoterol combination (18/12 mcg) or Tiotropium alone (18 mcg) on two separate days, atleast four days apart.

Results

Efficacy

Tiotropium + Formoterol produced a significantly better mean difference in area under the curve for both FEV₁ and FVC when measured over 24 hours.

Tiotropium + Formoterol in combination showed a faster onset of action compared to Tiotropium alone.

Tiotropium + Formoterol in combination showed longer duration of action compared to Tiotropium alone.

The mean difference in the trough (24 hour values) from baseline were significantly better with Tiotropium + Formoterol in combination than Tiotropium alone

Difference from baseline in trough FEV₁, FVC and IC values

Conclusion

Tiotropium + Formoterol provides better efficacy in terms of onset and duration of action, mean difference in AUC for FEV₁ and FVC, mean differences in trough compared to Tiotropium alone.
Tiotropium + Formoterol in single inhaler improves compliance and convenience.

Presented at American College of Chest Physicians (ACCP) Annual meeting, 2005

0

0

Related Topics