Obesity and heritability had a significant impact on the prevalence of hypertension, dyslipidemia, and type 2 diabetes mellitus (T2DM). Cross-sectional research was conducted to assess the effects of obesity on the prevalence of each in the same population together with a family history (FH) of dyslipidemia (DL), hypertension (HT), and T2DM. 

The effects of a family history (FH) and body mass index (BMI) on the prevalence of such diseases were examined cross-sectionally among 41,931 individuals who had health examinations. The corresponding prevalences of hypertension, DL, and T2DM were 5%, 20%, and 48%.

The results of the logistic regression analysis demonstrated that the ORs for all three had risen with the number of positive cases of FH and were prominent for T2DM. In comparison to BMI 20.0-21.9 and no positive family history, a family history of obesity and an elevated BMI were additively linked to the prevalence of the three illnesses.

Additionally, the number of family members with FH positive (0,1, 2, ≥3) and obesity were additively connected to a greater FH of the three diseases, in contrast to non-obesity and no family history of any of these illnesses.

When the number of individuals with the family history of Type 2 diabetes mellitus was ≥3 (14.4 [8.88-23.5]), the OR rose significantly in non-obese participants. However, when the number of individuals with the family history of Type 2 diabetes mellitus was 2 (12.2 [8.85-16.9]), the OR increased significantly in obese people. The findings implied that avoiding obesity might help with lowering the frequency of these illnesses in those with a high number of FH-positive family members, particularly for type 2 diabetes mellitus (T2DM).

1666-P: American Diabetes Association (ADA) 84th Scientific Sessions, 2024, 21- 24 June 2024, Orlando, Florida.