In a pilot genome-wide association study, researchers aimed to investigate the variants of specific genes involved in metabolic syndrome associated with psoriasis. Previous research had indicated a connection between the two conditions due to shared inflammatory and cytokine-mediated pathways. The present study involved 95 psoriasis patients, categorized into groups of (38 patients) and (57 patients) with metabolic syndrome. Genotyping, imputation, and quality checks were performed to identify gene variants associated with metabolic syndrome in psoriasis. The results revealed 76 gene polymorphisms that conferred an increased risk of metabolic syndrome in psoriasis patients. Notably, four single nucleotide polymorphisms (rs17154774 of FRMD4A, rs77498336 ofGPR116, rs75949580, and rs187682251 of MAPK4) exhibited the strongest association between metabolic syndrome and psoriasis. Remarkably, the epidermal growth factor receptor protein played a central role in the interactions among these gene polymorphisms. This study's findings unveiled previously unidentified genetic markers associated with metabolic syndrome in psoriasis patients. These discoveries emphasize the potential for future genetic studies to delve deeper into the development of metabolic syndrome in psoriasis, ultimately paving the way for preventive measures.

Poster ID 1196, European Academy of Dermatology and Venereology (EADV), Berlin 11-14 October 2023