Acne, a complex skin condition, has been associated with changes in the gut microbiome. This study investigated the relationship between acne and gastrointestinal symptoms (GIS), aiming to describe the frequency of dysbiosis-related GIS in a population from Bogota, Colombia. A retrospective cross-sectional observational study was conducted from June 2020 to December 2022, involving 619 patients diagnosed with acne at a dermatologic center in Bogota. The results revealed that of the total patients, 65.53% were female, with a mean age of 21.6 years. The age group most affected by GIS was 12-24 years, accounting for 56.31% of patients. Out of the total, 383 patients (61.97%) exhibited GIS. Among these, 129 individuals (20.87%) experienced one symptom, while 111 patients (17.96%) had two symptoms. Abdominal pain was the most frequent, affecting 37.70% of the patients, followed by alterations in bowel habits (36.41%), abdominal distension (35.6%), flatulence (35.28%), and dyspepsia (27.51%). In addition, 18.09% of patients had a diagnosed gastrointestinal disease, with gastritis being the most common comorbidity. The study indicated a higher prevalence of acne and gastrointestinal disorders among women. Because dysbiosis is associated with poor eating habits, and considering that a significant portion of the studied patients fell within the 12 to 24-year age group, it is advisable for future prospective investigations to assess the long-term effects of diet on the development of gastrointestinal problems and inflammatory skin conditions like acne. Additionally, interdisciplinary management should be considered as part of acne treatment, as a considerable proportion of patients had gastrointestinal comorbidities, potentially underdiagnosed. Further research is needed to understand whether gastrointestinal symptoms precede the onset of gastrointestinal and skin diseases.