Post-exposure prophylaxis (PEP) is the method of preventing exposures of HIV to blood and body fluids and it is considered to be the most important strategy for preventing occupationally acquired human immunodeficiency virus (HIV) infection. It refers to the prophylactic use of antiretrovirals to prevent establishment of HIV infection after an occupational exposure to HIV. PEP is majorly used for health care professionals who come in contact with blood or bloody fields in the hospital or laboratory. The current WHO guidelines recommends antiretroviral drug regimens and duration of prophylaxis post exposure of HIV in Health care professionals.