Paracetamol has the advantage of being the only non-opioid analgesic available in oral, rectal and now intravenous formulations. The intravenous route is especially advantageous in postsurgical situations when oral (e.g. infections with severe fever or vomiting) or rectal (e.g. high variability in uptake and bioavailability) routes are not suitable or effective, or patients have contrainidications to the administration of NSAIDs or opioid analgesics. This presentation covers intravenous paracetamol in details with the pharamacokinetics, probable mode of action, indications, contrainidications, warnings and precautions.