Carbapenems are preferred as an empirical therapy for the treatment of serious infections since last two decades, and still holds its position in current antibacterial armamentarium. But, as the treatment of resistant pathogens becomes difficult and very few new antimicrobial agents are available after development of carbapenem resistance, the best approach is to optimize the currently available antimicrobials. This set of slides highlights the rationale behind the optimization of carbapenem therapy by using the 3D approach: Right Dose, Right Duration and Right Drug combination.